A5031651345- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Radiomics and Machine Learning in Medical Imaging
- Bladder and Urothelial Cancer Treatments
- Urologic and reproductive health conditions
- Colorectal Cancer Screening and Detection
- Molecular Biology Techniques and Applications
- Renal cell carcinoma treatment
- Colorectal Cancer Surgical Treatments
- Advanced X-ray and CT Imaging
- Advanced Radiotherapy Techniques
- Urinary and Genital Oncology Studies
- AI in cancer detection
- MRI in cancer diagnosis
- Statistical Methods in Clinical Trials
- Clinical practice guidelines implementation
- Surgical Simulation and Training
- Cancer Immunotherapy and Biomarkers
- Advanced Neural Network Applications
- Genital Health and Disease
- Anatomy and Medical Technology
- Health, Environment, Cognitive Aging
- Pediatric Urology and Nephrology Studies
- Artificial Intelligence in Healthcare and Education
- Lung Cancer Diagnosis and Treatment
Karolinska Institutet
2016-2024
Saint Göran Hospital
2020-2024
Karolinska University Hospital
2016-2024
Institute of Molecular Medicine
2021
St Göran's Children's Hospital
2009
High rates of overdiagnosis are a critical barrier to organized prostate cancer screening. Magnetic resonance imaging (MRI) with targeted biopsy has shown the potential address this challenge, but implications its use in context screening unknown.We conducted population-based noninferiority trial which men 50 74 years age from general population were invited by mail participate; participants prostate-specific antigen (PSA) levels 3 ng per milliliter or higher randomly assigned, 2:3 ratio,...
Importance Magnetic resonance imaging (MRI) has been proposed to enhance the benefit-to-harm ratio of prostate cancer screening, but data on repeated screening outcomes are lacking. Objective To describe prostate-specific antigen (PSA)–based with MRI and biopsies at repeat screening. Design, Setting, Participants This secondary analysis examined population-based, screen-by-invitation STHLM3-MRI randomized clinical trial, which recruited Swedish men aged 50 74 years. Men were eligible for 2 3...
Objective: To describe study design and procedures for a prospective randomized trial investigating whether radical prostatectomy (RP) ± radiation improves cause-specific survival in comparison with primary treatment (RT) androgen deprivation (ADT) patients locally advanced prostate cancer (LAPC).Materials methods: SPCG-15 is prospective, multi-centre, open phase III trial. Patients are to either standard (RT + ADT) or experimental (RP extended pelvic lymph-node dissection addition of...
Objectives To analyse oncological and functional outcomes 12 months after treatment of very‐low‐risk prostate cancer with radical prostatectomy in men who could have been candidates for active surveillance. Patients Methods We conducted a prospective study all underwent at one 14 participating centres. Validated patient questionnaires were collected baseline by independent healthcare researchers. Biochemical recurrence ( BCR ) was defined as prostate‐specific antigen PSA ≥0.25 ng/ mL or...
To evaluate the learning progress of less experienced readers in prostate MRI segmentation.
Importance Prostate cancer guidelines often recommend obtaining magnetic resonance imaging (MRI) before a biopsy, yet MRI access is limited. To date, no randomized clinical trial has compared the use of novel biomarkers for risk estimation vs MRI-based diagnostic approaches prostate screening. Objective evaluate biomarker-based (Stockholm3 scores or prostate-specific antigen [PSA] levels) with systematic biopsies an MRI-enhanced strategy (PSA levels and targeted biopsy) detection clinically...
To investigate diagnostic accuracy of multiphase computed tomography urography (MCTU) and visual assessment at ureterorenoscopy (URS) for detection upper tract urothelial carcinoma (UTUC).Consecutive patients referred to our tertiary care centre were included in a prospective study covering the period 2005 2012. The underwent initial imaging URS with focal samples taken. Cytopathological results served as reference standard.We investigated 174 renal units (RUs; pelvis adjacent ureter) 148...
Overtreatment of localised prostate cancer is substantial despite increased use active surveillance. No randomised trials help define how to monitor patients or when initiate treatment with curative intent. A randomised, multicentre, intervention trial designed evaluate the safety an MRI-based surveillance protocol, standardised triggers for repeated biopsies and radical treatment. The aim reduce overtreatment cancer. 2000 men will be randomly allocated either according current practice at...
Purpose Tensor‐valued diffusion encoding provides more specific information than conventional diffusion‐weighted imaging (DWI), but has mainly been applied in neuroimaging studies. This study aimed to assess its potential for the of prostate cancer (PCa). Methods Seventeen patients with histologically proven PCa were enrolled. DWI was performed linear and spherical tensor using a maximal b‐value 1.5 ms/µm 2 voxel size 3 × 4 mm . The gamma‐distribution model used estimate mean diffusivity...
BackgroundTo investigate the reliability with which healthcare professionals different levels of expertise are able to impart exact location prostate cancer (PCA) after (A) reading written magnetic resonance imaging (MRI) reports, (B) attending MRI presentations in multidisciplinary team meetings (MDT), and (C) examining 3D printed models, represents a new technology describe PCA lesions. MethodsWe used three cases assess information tools.Construct validation was performed using two groups...
Stockholm3 is a risk model that combines the prostate-specific antigen (PSA) test, other plasma protein biomarkers, single nucleotide polymorphisms, and clinical variables. The STHLM3-MRI study (NCT03377881) found test with magnetic resonance imaging (MRI) combined targeted systematic biopsies maintained sensitivity for clinically significant cancers, reduced number of benign insignificant cancers.To assess cost-effectiveness MRI-based screening prostate cancer using either as reflex or PSA...
The Capio Prostate Cancer Center (Capio PCC) in Stockholm, Sweden, adopts a comprehensive diagnostic approach, utilizing prostate-specific antigen (PSA), Stockholm3, and magnetic resonance imaging (MRI) for prostate cancer risk assessment, followed by targeted systematic biopsies high-risk cases.
There is no high-grade evidence for surgery as primary treatment locally advanced prostate cancer. The SPCG-15 study the first randomized trial comparing surgical with radiotherapy.To describe baseline characteristics of 600 men in study. will compare mortality and functional outcomes.This a Scandinavian prospective, open, multicenter phase III clinical aiming to randomize 1200 men.Radical prostatectomy or without consecutive radiotherapy (experimental) neoadjuvant androgen deprivation...
Introduction Prostate cancer is a leading cause of death among men in the Western world. Early detection prostate has been shown to decrease mortality, but limitations with low specificity unnecessary biopsies and overdiagnosis low-risk cancers. The STHLM3 trial paved way for improved early using blood-based test identifying at increased risk harbouring significant cancer. Targeted based on MRI images have non-inferior sensitivity detect number non-significant cancers referred biopsy...
In 2009, vinflunine was introduced as a second-line treatment to be used after the failure of platinum therapy in patients with metastatic urothelial carcinoma (mUC). The present study investigated administered mUC standard clinical practice aim evaluating patterns, response, survival parameters and side-effects. Data were collected retrospectively from first 100 treated at three Nordic cancer centers associated Urothelial Cancer Oncology Group. overall response rate 23% complete observed...
Active surveillance (AS) for men with low-risk prostate cancer (PC) can lead to patient morbidity and healthcare overutilization. The aim of this study was evaluate an AS protocol using the Stockholm3 test magnetic resonance imaging (MRI) reduce biopsy intensity.We conducted a prospective multicenter 280 invited from contemporary screening (STHLM3), Gleason Score (GS) 3 + PC on current protocol. Patients underwent prostate-MRI blood sampling analysis including protein biomarkers, genetic...
In the diagnostic pathway for early detection of prostate cancer, MRI, biopsies, and pathology are included. The shift towards 'MRI first' avoids unnecessary biopsies reduces overdiagnosis [1] but demands high standards Prostate Imaging-Reporting Data System (PI-RADS) [2] grading accuracy in targeted biopsies. Formulating a comprehensive assessment optimal patient management is challenging today's urologists as volume complexity data grow. Quality registers crucial evaluating, comparing,...