A5034942124- Radiopharmaceutical Chemistry and Applications
- Medical Imaging Techniques and Applications
- Medical Imaging and Pathology Studies
- Neuroscience and Neuropharmacology Research
- Alzheimer's disease research and treatments
- Neurotransmitter Receptor Influence on Behavior
- Radiation Therapy and Dosimetry
- Glioma Diagnosis and Treatment
- Dementia and Cognitive Impairment Research
- Functional Brain Connectivity Studies
- Chemical Reactions and Isotopes
- Visual perception and processing mechanisms
- Receptor Mechanisms and Signaling
- COVID-19 Impact on Reproduction
- Inhalation and Respiratory Drug Delivery
- Immune Response and Inflammation
- Chemical Synthesis and Characterization
- Nuclear Physics and Applications
- Diet and metabolism studies
- Nutrition and Health in Aging
- Molecular Sensors and Ion Detection
- Cancer Treatment and Pharmacology
- Spatial Neglect and Hemispheric Dysfunction
- Influenza Virus Research Studies
- Cannabis and Cannabinoid Research
Translational Research in Oncology
2025
University of Alberta
2012-2024
Alberta Health Services
2020-2024
Karolinska Institutet
2001-2021
Karolinska University Hospital
2000-2012
Western General Hospital
2011
University of Edinburgh
2011
Glanrhyd Hospital
2009
Hôpital Purpan
2009
KU Leuven
2009
Positron-emission tomography and the radioligand [11C](R)-PK11195 have been used for imaging of translocator protein (TSPO) applied to map microglia cells in brain neuropsychiatric disorders. binding has quantified using reference region approaches, with defined anatomically or unsupervised supervised clustering algorithms. Kinetic compartment modelling so far not presented. In present test-retest study, we examine characteristics detail, classical analysis a metabolite-corrected arterial...
Abstract Background Nuclear medicine has made enormous progress in the past decades. However, there are still significant inequalities patient access among different countries, which could be mitigated by improving to and availability of radiopharmaceuticals. Main body This paper summarises major considerations for a suitable pharmaceutical regulatory framework facilitate These include distinct characteristics radiopharmaceuticals require dedicated regulations, considering impact variable...
Current positron emission tomography (PET) radioligands for detection of Abeta amyloid in Alzheimer's disease (AD) are not ideal quantification. To improve the signal to noise ratio we have developed radioligand [(11)C]AZD2184 and report here first clinical evaluation.Eight AD patients four younger control subjects underwent 93-min PET measurements with [(11)C]AZD2184. A approach using cerebellum as reference region was applied determine binding parameters.Brain uptake peaked within 1 min at...
A novel radioligand for positron emission tomography (PET) imaging of serotonin 5-HT 1B receptors, [ 11 C]AZ10419369, has been recently described. In this study, the potential quantitative analysis C]AZ10419369 binding to central receptors was evaluated in human subjects. PET measurements were performed after injection 10 Data analyzed with kinetic modeling and linear graphical using arterial plasma as input function, reference tissue models cerebellar cortex region. Binding highest...
Evaluation of positron emission tomography (PET) using (18)fl 18F-2-fluoro-2-deoxy-D-glucose (18FDG) and L-methyl-11C-methionine in the diagnosis staging urinary bladder carcinoma.Twenty-three patients with biopsy-proven carcinoma were examined PET after intravenous injection 11C-methionine; 2 also 18FDG. The results from investigations compared CT or MR findings TNM classification before treatment.The excretion 18FDG prevented distinction primary tumour surrounding tracer. With...
Abstract This study reports the high-yield production of a novel 133/135 La theranostic pair at 22 MeV proton beam energy as an attractive alternative to recently introduced 132/135 pair, demonstrating over order magnitude increase (231 ± 8 MBq 133 and 166 5 135 End Bombardment (EOB)) compared 11.9 (0.82 0.06 132 19.0 1.2 La) for 500 µA·min irradiations. A new sealed solid cyclotron target is introduced, which fast assemble, easy handle, storable, contains reusable components. Radiolabeling...
Theranostic isotope pairs have gained recent clinical interest as they can be labeled to the same tracer and applied for diagnostic therapeutic purposes. The goals of this study were A) investigate cyclotron production clinically relevant <sup>133</sup>La activities using natural isotopically enriched barium target material, B) compare fundamental positron emission tomography (PET) phantom imaging characteristics with common PET radionuclides, C) demonstrate in vivo preclinical tumor...
[18F]Fluorodeoxyglucose (FDG) is widely used in PET/CT imaging to detect large vessel vasculitis giant cell arteritis (GCA), but its performance suboptimal patients receiving glucocorticoids. We aimed compare [68Ga]Ga-HA-DOTA-TATE, a somatostatin 2-analogue tracer, [18F]FDG pilot study of with GCA. Eight active GCA were prospectively, sequentially scanned both and [68Ga]Ga-HA-DOTA-TATE imaging. Images evaluated by 2 blinded nuclear medicine specialists. Tracer uptake was assessed 8 vascular...
Abstract β‐Amyloid accumulation is associated with the pathogenesis of Alzheimer's disease (AD). AZD2184, a new radioligand for high‐contrast positron emission tomography (PET) imaging Aβ‐deposits, has recently been developed and characterized in vitro rodents ex vivo. The objective this study was to label AZD2184 carbon‐11, perform vivo characterization [ 11 C]AZD2184 ([ C] 5 ) cynomolgus monkey brain as well whole‐body dosimetry, examine metabolism labeled radioligand. prepared by two‐step...