Importance The combination of prostate-specific antigen (PSA) testing with magnetic resonance imaging (MRI) for prostate cancer detection has rarely been evaluated in a screening context. STHLM3-MRI screening-by-invitation study ( NCT03377881 ) reported the benefits using MRI subsequent combined targeted and standard biopsies compared alone. Objective To investigate cost-effectiveness alone among men aged 55 to 69 years Sweden, based on evidence from study. Design, Setting, Participants This...

Background: In Sweden, the cervical cancer screening programme is based on primary human papillomavirus (HPV) testing with either clinician-collected sampling or home-based vaginal self-sampling. We assessed effectiveness and cost-effectiveness of HPV self-collected for unvaccinated cohorts Swedish women. Methods: A model-based analysis was performed to project long-term costs quality-adjusted life-years (QALYs). Screening strategies included no screening, 18 36 self-sampling strategies,...

Objective This study aims to identify possible barriers and facilitators of cervical cancer screening by (a) estimating time travel costs other direct non-medical incurred in attending clinic-based screening, (b) investigating compliance reasons for noncompliance, (c) determining women's knowledge human papillomavirus (HPV), its relationship cancer, HPV prevention, (d) correlates compliance. Materials Methods 1510 women the program Stockholm, Sweden were included. Data on sociodemographic...

Abstract Background Incidence and prevalence of prostate cancer in Sweden have increased markedly due to prostate-specific antigen (PSA) testing. Moreover, new diagnostic tests treatment technologies are expected further increase the overall costs. Our aims were (i) estimate societal costs for existing testing, diagnosis, management cancer, (ii) provide reference values future cost-effectiveness analyses screening treatment. Methods Taking a perspective, this study aimed investigate annual...

Abstract Background Human papillomavirus (HPV) testing is recommended in primary cervical screening to improve cancer prevention. An advantage of HPV that it can be performed on self-samples, which could increase population coverage and result a more efficient strategy identify women at risk developing cancer. Our objective was assess whether repeated self-sampling for cost-effective comparison with Pap smear cytology detection intraepithelial neoplasia grade 2 or (CIN2+) increasing...

Background Cervical cancer imposes considerable economic burden on societies and individuals. There is lack of evidence regarding this from the developing world particularly sub-Saharan Africa. Therefore, study aimed to estimate societal costs cervical in Eswatini. Materials methods The cost illness (CoI) was applied using national specific clinical registry data hospitals, registries reports determine prevalence intraepithelial neoplasia (CIN) Eswatini 2018. Cost included direct medical...

Stockholm3 is a risk model that combines the prostate-specific antigen (PSA) test, other plasma protein biomarkers, single nucleotide polymorphisms, and clinical variables. The STHLM3-MRI study (NCT03377881) found test with magnetic resonance imaging (MRI) combined targeted systematic biopsies maintained sensitivity for clinically significant cancers, reduced number of benign insignificant cancers.To assess cost-effectiveness MRI-based screening prostate cancer using either as reflex or PSA...

Abstract Background Human papillomavirus ( HPV ) testing is not currently used in primary cervical cancer screening Sweden, and corresponding cost‐effectiveness unclear. Objective From a societal perspective, to evaluate the of high‐risk HR )‐ using self‐collected vaginal samples. Design A analysis. Setting The Swedish organized program. Methods We constructed model simulate natural history data on risk. For base‐case analysis we evaluated two strategies with different intervals: (i)...

High-risk (HR) human papillomavirus (HPV) infection is an established cause of malignant disease. We used a societal perspective to estimate the cost HR HPV-related cervical, vulvar, vaginal, anal, and penile precancer cancer, oropharyngeal cancer in Sweden 2006, 1 year before HPV vaccination became available country.This prevalence-based cost-of-illness study diagnosis-specific data from national registries determine number precancers cancers. The HPV-attributable fractions these diseases...

The present study aimed to identify the factors that independently contribute disease recurrence among women first‑time treated for high‑grade cervical intraepithelial neoplasia (CIN) during 4‑6 years of follow‑up. Overall, 529 530 eligible patients participated; these all attended a 1st follow‑up appointment ~6 months post‑conization, at which time high‑risk human‑papillomavirus (HPV) testing, liquid‑based cytology and colposcopy were performed. Full data on margin excision status, other...

Background Low back pain (LBP) is a multifactorial and the most prevalent musculoskeletal disorder, whose economic burden of global concern. Evidence suggests that LBP in increasing will continue rising with greatest occurring low-and-middle-income-countries (LMICs). This study sought to determine KwaZulu-Natal, South Africa from providers perspective. Methods We used retrospective prevalence-based cost-of-illness methodology estimate direct medical cost LBP. Direct costs constituted...

Background Human papillomavirus (HPV) has proven to be the cause of several severe clinical conditions on cervix, vulva, vagina, anus, oropharynx and penis. Several studies have assessed costs cervical lesions, cancer (CC), genital warts. However, few been done in Africa none Swaziland. Cost analysis is critical providing useful information for economic evaluations guide policymakers concerned with allocation resources order reduce disease burden. Materials methods A prevalence-based cost...

Objective Costs associated with HPV-related diseases such as cervical dysplasia, cancer, and genital warts have not been evaluated in Sweden. These costs must be estimated order to determine the potential savings if these were eradicated assess combined cost-effectiveness of HPV vaccination cancer screening. The present study aimed estimate prevention, management, treatment from a societal perspective Sweden 2009, 1 year before quadrivalent program was implemented. Methods Materials Data...

Objective Women with high-grade cervical intraepithelial neoplasia (CIN) are at increased risk for developing cancer. We examine how women CIN perceive their own risk, and about pertinent knowledge concerning human high-risk papillomavirus (HPV), Methods All patients who underwent first-time treatment of (grade 2+) were followed-up 6-months the Karolinska University Hospital, Stockholm, Sweden invited to participate in present study. This included completion a questionnaire examining...

This study aims to investigate acceptance of vaginal self-sampling for high-risk human papilloma virus (HPV) among long-term screening non-attenders at increased cervical cancer risk and identify leverage points promote adherence these women. Forty-three performed home HPV, had positive HPV results, subsequently attended gynecologic examination. Sixteen (37.2%) high-grade intraepithelial neoplasia (CIN2 or 3), two invasive cancer. Forty-one women completed a questionnaire concerning Specific...

Abstract Background Prostate cancer is the fifth cause of mortality among men worldwide. However, there limited data on costs associated with prostate in low- and middle-income countries particularly sub-Saharan region. From a societal perspective, this study aims to estimate cost Eswatini. Methods This prevalence–based cost-of-illness used diagnosis specific from national registries during 2018. The prevalence-based approach was employing both top down bottom up costing approaches. Costs...

Abstract Background Treatment for resectable oral cavity cancer (OCC) often includes combinations of surgery and radiotherapy (RT), but there is no conclusive information on the preferred treatment order. The aim this study was to assess costs cost-effectiveness two alternative regimens patients with OCC, reflecting pre- post-operative RT, from a societal perspective. Methods used data ARTSCAN 2 randomised controlled trial, which compares pre-operative accelerated RT conventionally...

Objective Self-sampling to test for high risk human papilloma virus (HPV) is becoming an increasingly important component of cervical cancer screening. The aim this observational study examine how women treated high-grade intraepithelial neoplasia (CIN) view HPV self-sampling. Methods Invited participate in the present were patients who had undergone treatment CIN (grade 2 or higher) and followed-up at 6-months Karolinska University Hospital, Stockholm. participants instructed as perform...

Abstract Objective . To assess the cost‐effectiveness of using human papillomavirus testing (HPV triage) in management women with minor cytological abnormalities Sweden. Design An economic analysis based on a clinical trial, complemented data from published meta‐analyses accuracy HPV triage. The study takes perspective Swedish healthcare system. Setting population‐based cervical cancer screening program. Methods A decision analytic model was constructed to evaluate triage compared repeat...

Background Primary vaginal carcinoma (PVC) is a rare malignancy. Established prognostic factors include tumour stage and age at diagnosis. The leucine-rich repeats immunoglobuline-like domains (LRIG)-1 protein functions as suppressor, but less known about the of LRIG2 LRIG3. present study aimed to evaluate expression LRIG proteins analyse their possible associations with clinical characteristics survival in cohort PVC patients. Methods We used immunohistochemistry investigate LRIG1, LRIG2,...

The causal relation between high-risk human papillomavirus (HPV) and cervical cancer its precursor lesions has led to the use of sensitive HPV molecular tests for screening. This study examined impact baseline status on future risk intraepithelial neoplasia grade 2 or worse (CIN2+) among women with cytology negative malignancy (NILM).This was a nested case-control including NILM participating in Swedish screening program 2005-2007. Ninety-six cases CIN2+ 5 age-matched controls per case were...

Background The incidence of oropharyngeal cancer (OPC) is increasing, particularly human papillomavirus (HPV)-associated OPC. aim this study was to specify the total societal cost OPC by HPV status, stage, and subsite using a bottom-up cost-of-illness approach. Methods We analyzed 121 consecutive patients with from Southern Health Care Region Sweden. estimated direct medical costs indirect (e.g., disease-related morbidity premature death) 1 month prior diagnosis until 3 years after treatment...

High-risk human papillomavirus (HPV) testing is a recommended triage approach for females with atypical squamous cells of undetermined significance (ASCUS), but due to its poor specificity this not patients low-grade intraepithelial lesions (LSIL). The objective the current study was determine microRNA (miR)-205 expression levels in liquid-based cytology (LBC) samples, and evaluate their ability predict cervical neoplasia grade 2/3 or worse (CIN2/3+) minor cytological abnormalities. LBC...