The majority of breast cancer patients die metastasis rather than primary tumors, whereas the molecular mechanisms orchestrating remains poorly understood. Long noncoding RNAs (lncRNA) have been shown to regulate occurrence and progression. However, lncRNAs that drive in their underlying are still largely unknown.lncRNAs highly expressed metastatic lymph nodes were identified by microarray. Survival analysis made Kaplan-Meier method. Cell proliferation, migration, invasion assay was...

This analysis examines the prevalence of self-reported unmet needs for health care and extent to which they were attributable perceived problems with service availability or accessibility acceptability.Most data are from 1998/99 cross-sectional household component Statistics Canada's National Population Health Survey; 1994/95 1996/97 used present trends 1998/99. The primary is based on 14, 143 respondents aged 18 older.Multivariate logistic regression was estimate association risk factors...

Abstract Long-wavelength, near-infrared small-molecule dyes are attractive in biophotonics. Conventionally, they rely on expanded aromatic structures for redshift, which comes at the cost of application performance such as photostability, cell permeability, and functionality. Here, we report a ground-state antiaromatic strategy showcase concise synthesis 14 cationic aminofluorene with mini (molecular weights: 299–504 Da) distinct spectra covering 700–1600 nm. Aminofluorene cell-permeable...

A quantum dot (QD) mode-locked laser as an active comb generator takes advantage of its small footprint, low power consumption, large optical bandwidth, and high-temperature stability, which is ideal multi-wavelength source for applications such datacom, interconnects, LIDAR. In this work, we report a fourth-order colliding pulse (CPML) based on InAs/GaAs QD gain structure, can generate ultra-stable frequency combs in the O-band with 100 GHz spacing at operation temperature up to 100°C....

Quantum dot lasers on silicon have gained significant interest over the past decade due to their great potential as an on-chip photonic light source. Here, we demonstrate multi-wavelength injection locking of InAs/GaAs quantum Fabry–Perot (FP) both GaAs and substrates by optical self-injection via external cavity. The number locked laser modes can be adjusted from a single peak multiple peaks tuning wavelength dependent phase mode spacing back-injected through Lyot filter. exhibit average...

Manufactured sand is one of the effective ways to alleviate extreme shortage natural in construction industry. This paper uses granite and limestone manufactured study effect high fines content on durability high-strength concrete, analyzes its influence mechanism by combining macro micro test methods. The results show that carbonation depth concrete smallest when 10%. When less than 15%, chloride sulfate impermeability are improved effectively. Through macroscopic microscopic tests, it...

According to births in the last year as reported China's 2000 census, total fertility rate (TFR) China was 1.22 children per woman. This estimate is widely considered be too low, primarily because some women who had out-of-quota according one-child family policy did not report those census enumerator. Analysis of trends derived by applying own-children method estimation 1990 and censuses indicates that true level TFR probably between 1.5 1.6 A decomposition analysis change 2000, based on our...

Abstract Background Metastasis is the predominant cause of mortality in patients with breast cancer. Long noncoding RNAs (lncRNAs) have been shown to drive important phenotypes tumors, including invasion and metastasis. However, lncRNAs involved metastasis their molecular cellular mechanisms are still largely unknown. Methods The transcriptional posttranscriptional processing LINC00478-associated cytoplasmic RNA (LacRNA) was determined by RT-qPCR, semiquantitative PCR 5′/3′ RACE....

This article examines the contextual effects of community environment on individual stigmatizing attitudes toward people with HIV/AIDS in China. Multilevel logistic regression models are used to analyze data 5,658 respondents aged 15-49 from 66 communities Baseline Information, Education, and Communication Survey for Prevention China, conducted by State Family Planning Commission 2000. The results show that a high level HIV/AIDS-related risk behavior low development associated increased...

The present work aims to introduce a novel and eco-friendly method, i.e., water-leaching pretreatment for extracting highly reactive biomass silica from rice husk (RH), viability as pozzolanic additive in cement. For comparison, the traditional acid method was also employed throughout experimental study. RH extracted using boiled deionized water solution leaching agents remove alkali metal impurities, then dried submitted pyrolysis treatment. results indicated that potassium found be major...

Abstract ATP plays a prominent role in shaping the evolution of immune cell responses to injury, infection, and cancer. However, real‐time monitoring levels vivo remains challenge, due lack reliable tools that work reversibly deep tissues. Herein, based on Förster resonance energy transfer (FRET) strategy, reversible ratiometric second near‐infrared window (NIR‐II) molecular fluorescent probe (CX‐RATP) is designed synthesized. CX‐RATP exhibits significant fluorescence ratio change with...

Quantum dot distributed feedback lasers with high optical reflection tolerance are of great significance as the isolator-free light sources for hybrid-silicon photonic integrated circuit. In this work, we experimentally investigate our O-band quantum lateral coupled lasers, using a fiber-based back reflector. The spectra show that laser can maintain stable output power and wavelength under external up to -6 dB. Moreover, side-mode suppression ratio over 50 dB is also maintained without...

The novel casting method of preplaced aggregate cement paste coating (PACPC) concrete is helpful in solving engineering problems. effects particle size distribution and W/C on groutability, mechanical properties, efficiency were investigated through experimental theoretical analysis. results showed that, with the increase proportion finer size, groutability first decreased then increased, while compressive strength increased decreased. Widening packing density by 12.3%, 12.7%, 30.3% but...

<title>Abstract</title> Molecular quantitative trait loci (molQTL) mapping is one of the most popular approaches to systematically characterize functional impacts genomic variants, leading advanced understanding regulatory mechanisms underpinning complex traits and diseases. However, when applied high-throughput molecular phenotypes, existing molQTL tools often implement simple linear models, overlooking inter-individual relatedness, false positives insufficient statistical power. Here, we...

Human epidermal growth factor receptor 2 (HER2)-positive invasive breast cancer (BC) accounts for 15-20% of all cases, requiring HER2-targeted neoadjuvant therapy (NAT). Despite the success trastuzumab and other treatments, many patients still experience inadequate responses, highlighting need more accurate accessible biomarkers to predict treatment outcomes. Serum HER2 (sHER2) levels, as a non-invasive biomarker, have shown promise in monitoring response; however, role sHER2 dynamics during...

Superplasticiser (SP) is now an indispensable ingredient for the production of concrete. However, its proper use a great concern because over-dosage could lead to drastic reduction in cohesiveness Furthermore, experience has indicated that SP demand, saturation dosage and causing segregation are highly dependent on powder content therefore effects not simple functions dosage. This study aims evaluate fresh properties cement paste containing condensed silica fume (CSF). A number samples with...

To reduce the shrinkage of concrete so as to alleviate various problems caused, a common strategy is decrease cement paste volume. Herein, it proposed add limestone fines fill into voids between aggregate particles that volume can be decreased more substantially. Following previous study on effectiveness adding replacement in reducing heat generation curing concrete, aim this evaluate hardened concrete. A number samples with added replace an equal are tested and results show addition could...

The study of this is to assess the current status and trend application breast reconstruction in China. A retrospective review all patients who had received surgical treatment for cancer Fudan University Shanghai Cancer Center between January 1999 June 2014 was performed. clinicopathological epidemiological parameters follow-up information each patient were collected. total 20,551 with 20,974 surgeries identified. Of those, rates mastectomy, conserving therapy, 81.2% (17,040 cases), 15.3%...

This study assesses the effects of socio-economic conditions and interaction between son preference China's one-child family planning policy on use maternal health care services their infant mortality in rural China, using nationally representative data from 2001 National Family Planning Reproductive Health Survey. The results show that while has continued to increase over time, large gaps still exist these survival by mother's education, community income, parity. Further improvements...

Recent studies have revealed that the use of limestone fines (LF) to replace an equal volume cementitious paste in concrete could improve strength and durability reduce carbon dioxide footprint production. However, there are different views on how why LF as a replacement without changing mix composition increase performance hardened concrete, bearing mind not inherently cementitious. In this work, effects addition packing density water film thickness (WFT) mixes were investigated, roles WFT...

Abstract Direct epitaxial growth of III–V quantum dot (QD) lasers on Si (001) substrates is recognized as a promising and low-cost method for realizing high-performance on-chip light sources in silicon photonic integrated circuits (PICs). Recently, the CMOS-compatible patterned with sawtooth structures have been widely implemented to suppress lattice mismatch induced defects antiphase boundaries heteroepitaxial high-quality materials Si. Considerable progresses made 1300 nm InAs/GaAs QD...

<p indent="0mm">Semiconductor mode-locked lasers (MLLs) can provide coherent optical frequency combs (OFCs) with high repetition rates and output power, which have been recognized as potential multi-wavelength sources used in communication field due to their compactness, high-efficiency, low-cost properties. In this article, we reviewed recent development of semiconductor MLL-based comb generation. Different approaches MLLs for OFC generation are synoptically summarized based on various...

Background The objective of this study was to determine an axillary pathologic complete response (pCR) and its influencing factors in patients with hormone receptor (HR)–positive breast cancer cytologically proven lymph node metastases. A prediction nomogram established provide information for the de‐escalation management these after neoadjuvant chemotherapy. Methods authors retrospectively enrolled all HR‐positive chemotherapy data set Fudan University Shanghai Cancer Center. All were...