A5040931952- Reproductive Biology and Fertility
- Ovarian function and disorders
- COVID-19 Clinical Research Studies
- COVID-19 and Mental Health
- Colorectal Cancer Surgical Treatments
- Long-Term Effects of COVID-19
- Assisted Reproductive Technology and Twin Pregnancy
- Lung Cancer Diagnosis and Treatment
- Esophageal Cancer Research and Treatment
- Ferroptosis and cancer prognosis
- COVID-19 and healthcare impacts
- Cancer, Lipids, and Metabolism
- SARS-CoV-2 and COVID-19 Research
- Anorectal Disease Treatments and Outcomes
- Healthcare professionals’ stress and burnout
- Plant-Microbe Interactions and Immunity
- Liver Disease Diagnosis and Treatment
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Cancer Immunotherapy and Biomarkers
- Plant-based Medicinal Research
- Cancer-related molecular mechanisms research
- Reproductive Health and Technologies
- Plant Molecular Biology Research
- Plant Reproductive Biology
- Medicinal Plants and Bioactive Compounds
University of Electronic Science and Technology of China
2021-2025
Southern Medical University
2025
Fujian Medical University
2025
Union Hospital
2025
Shanghai Ninth People's Hospital
2019-2024
Shanghai Jiao Tong University
2019-2024
Xiangya Hospital Central South University
2024
Central South University
2024
Zhongnan Hospital of Wuhan University
2019-2023
Wuhan University
2019-2023
Renal ischemia/reperfusion injury (IRI) is a significant challenge in perioperative medicine and related to oxidative programmed cell death. However, the role of ferroptosis, newly discovered form death, has not been evaluated widely. Pannexin 1 (PANX1), an ATP-releasing pathway family protein, pro-apoptotic effects during kidney injury. Here, we demonstrate that PANX1 deletion protects against renal IRI by regulating ferroptotic Panx1 knockout mice subjected had decreased plasma creatinine,...
Abstract Data are scarce regarding the comorbid mental disorders and their management among COVID-19 patients. This study described clinical characteristics of patients treated in psychiatric inpatient settings due to first-onset Wuhan, China. electronic medical records-based included 25 with 55 without (control group). collected ICD-10 diagnoses disorders, respiratory symptoms, treatments, outcomes. Adjustment disorder ( n = 11, 44.0%) acute transient psychotic associated stress 6, 24.0%)...
The chemokine CXCL9 (C-X-C motif ligand 9) has been reported to be required for antitumour immune responses following checkpoint blockade. In this study, we sought investigate the potential value of according in patients with breast cancer (BC). A variety open-source databases and online tools were used explore expression features prognostic significance BC its correlation immune-related biomarkers followed by subsequent verification immunohistochemistry experiments. mRNA level was found...
Dydrogesterone (DYG) has been demonstrated to be an alternative progestin in the progestin-primed ovarian stimulation (PPOS) protocol with comparable oocyte retrieval and pregnancy outcomes. However, its safety regarding neonatal outcomes congenital malformations is still unclear.This retrospective cohort study included 3556 live-born infants after vitro fertilization vitrified embryo transfer cycles using DYG + human menopausal gonadotropin (hMG) (n=1429) or gonadotropin-releasing hormone...
Gut microbiota and bile acid metabolism play crucial roles in the progression of nonalcoholic fatty liver disease (NAFLD). Early evidence demonstrates that Ginsenoside Re (Re) possesses pharmacological effects on NAFLD, but its mechanisms action are not well understood. This study aimed to investigate hepatic protective NAFLD elucidate relevant mechanisms. The treatments (10, 20, or 40 mg/kg) against high-fat diet-induced were initially tested male C57BL/6 mice. Then, a separate mouse group...
Repair and regeneration of oral maxillofacial tissue defects remain significant challenges, mainly due to the limitations existing treatment approaches. Conventional methods such as transplantation, scaffolds, growth factors, stem cell therapies often face obstacles, including donor shortages, insufficient vascularization, safety concerns. There is an urgent need for innovative therapeutic strategies effectively promote vascular while minimizing complications. Black phosphorus nanosheets...
Post-traumatic growth is regarded as a screening indicator for quality of life hemodialysis patients. Interpersonal relationships and forgiveness patients may play an important role in improving post-traumatic growth. Few studies reveal the relationship between interpersonal relationships, forgiveness, This study aimed to explore among sample analyzed influencing factors associated with In cross-sectional involving convenience from August October 2022, 369 nine hospitals completed...
Dydrogesterone (DYG) is an alternative progestin in progestin-primed ovarian stimulation (PPOS) protocol with weaker pituitary suppression than medroxyprogesterone acetate (MPA) normal ovulatory women. However, the endocrinological characteristics, oocyte retrieval and pregnancy outcomes of DYG application polycystic syndrome (PCOS) patients undergoing vitro fertilization (IVF) remain unclear.This retrospective cohort study included 420 PCOS who underwent controlled human menopausal...
Non-elective freeze-all policy has been increasingly utilized in assisted reproductive treatment, but the optimal timing of frozen-thawed embryo transfer (FET) after controlled ovarian stimulation (COS) remains to be investigated.This retrospective cohort study included 2,998 patients who underwent their first FETs COS cycles using non-elective strategy from Jan 2013 Dec 2016 at a tertiary-care academic medical center. Patients were divided into "immediate" group which FET took place within...
The transplantation of mesenchymal stem cells (MSCs) in patients with premature ovarian failure (POF) could lead to clinical improvement. the ovaries among other methods have been reported various animal models, however, there is little evidence regarding optimal method, including safety and efficiency for treatment age associated hypofunction.To establish most effective route MSCs, explore resistance therapy, its role natural aging process ovaries.Highly purified MSCs were injected...
As a magneto-optical effect, the Faraday effect depends on Verdet constant of magnetic materials and enables integrated optical modulators nonreciprocal photonic devices. Ferrimagnetic garnet, e.g. yttrium iron garnet (YIG) is most studied material for terahertz (THz) effects. However, current works neglect correlation between electromagnetic (EM) parameters, which vital design high-performance THz non-reciprocal Here, we investigate mechanisms broadband rotations in undoped YIG rare-earth...
Our study aimed to investigate the factors affecting prognosis of patients with mental disorders COVID-19. All who were diagnosed COVID-19 at intensive care unit Wuhan Mental Health Center during period January 3 March 1, 2020 selected. The influence baseline characteristics, clinical symptoms, laboratory parameters and types on analyzed. According their final prognosis, divided into deceased group (5 patients) cured (25 patients). mortality rate dementia was significantly higher than that...
Resistance to tamoxifen remains a prominent conundrum in the therapy of hormone-sensitive breast cancer. Also, molecular underpinnings leading resistance remain unclear. In present study, we utilized Gene Expression Omnibus database identify that SOX11 might exert pivotal function conferring was found be markedly upregulated at both messenger RNA and protein levels established MCF-7-Tam-R cells compared parental counterparts. Moreover, able activate transcription slug via binding its...
Early prediction of response to neoadjuvant chemotherapy (NAC) is critical in choosing appropriate chemotherapeutic regimen for patients with locally advanced breast cancer. Herein, we sought identify potential biomarkers predict the cancer patients.Three genomic profiles acquired by microarray analysis from subjects or without residual tumors after NAC downloaded GEO database were used screen differentially expressed genes (DEGs). An array public databases, including ONCOMINE, cBioportal,...
Background: Cytokine levels can be changed in methamphetamine (METH) use disorders (MUDs) and primary psychosis. The present study assessed serum of some kinds interleukins (ILs) METH-associated psychosis (MAP) their relationships with psychotic symptoms cognitive dysfunction. Methods: Serum IL-2R, IL-6, IL-8, IL-10 were examined by chemiluminescence assays MAP patients ( n = 119) healthy controls 108). Positive Negative Syndrome Scale (PANSS) Montreal Cognitive Assessment (MOCA)...
Pregnancy-associated breast cancer (PABC) is a rare disease with increasing incidence. The prognosis, pregnancy outcomes and subsequent ovarian function of PABC patients are attracting attention.Sixty-three 126 age-matched non-PABC were obtained in Tongji Hospital from January 2011 to September 2019. clinical characteristics compared those patients. neonatal diagnosed during (BCP) described. Nonparametric tests, the χ2-test Kaplan-Meier, Cox regression binomial logistic used for...
Abstract Medulloblastoma (MB) is a malignant brain tumour that highly common in children and has tendency to spread the spinal cord. MB thought be metabolically driven tumour. Understanding cell metabolic patterns characteristics can provide promising foundation for understanding pathogenesis developing treatments. Here, by analysing RNA-seq data of samples from Gene Expression Omnibus (GEO) database, 12 differentially expressed metabolic-related genes (DE-MRGs) were chosen construction...
Abstract Aim Anastomotic leakage ( AL ) is one of the most feared postoperative complications after anterior resection (AR) rectal cancer. An adequate blood supply at anastomotic site regarded as a prerequisite for healing. We hypothesize that Aortic Calcification Index ACI might reflect severity atherosclerosis in patients, and thereby be risk factor . Method was investigated retrospectively according to definition International Study Group Rectal Cancer 423 cancer patients who underwent...