A5100658291- Immune Cell Function and Interaction
- Plant nutrient uptake and metabolism
- Plant Molecular Biology Research
- IL-33, ST2, and ILC Pathways
- Eosinophilic Esophagitis
- Ubiquitin and proteasome pathways
- Geothermal Energy Systems and Applications
- Plant Micronutrient Interactions and Effects
- Protein Degradation and Inhibitors
- Peptidase Inhibition and Analysis
- Advanced oxidation water treatment
- Glaucoma and retinal disorders
- Cancer-related molecular mechanisms research
- Soil and Unsaturated Flow
- T-cell and B-cell Immunology
- Retinal Diseases and Treatments
- interferon and immune responses
- Retinal Imaging and Analysis
- Cell Adhesion Molecules Research
- CO2 Sequestration and Geologic Interactions
- Immunotherapy and Immune Responses
- MicroRNA in disease regulation
- Plant Parasitism and Resistance
- Gut microbiota and health
- Plant biochemistry and biosynthesis
Inner Mongolia Autonomous Region Hospital of Traditional Chinese Medicine
2025
China Agricultural University
2016-2024
Zhengzhou People's Hospital
2011-2024
Xian Yang Central Hospital
2011-2024
Chinese Academy of Sciences
2024
Drexel University
2024
Nanjing Agricultural University
2023-2024
China University of Petroleum, Beijing
2024
WuXi AppTec (China)
2022-2024
University of Science and Technology of China
2024
The IL-33-type 2 innate lymphoid cell (ILC2) axis has an important role in tissue homeostasis, inflammation, and wound healing. However, the relative importance of this immune pathway for immunotherapy against inflammation damage remains unclear. Here, we show that treatment with recombinant mouse IL-33 prevented renal structural functional injury reduced mortality mice subjected to ischemia-reperfusion (IRI). Compared control-treated IRI mice, IL-33–treated had increased levels IL-4 IL-13...
Foxtail millet (FM) [Setaria italica (L.) Beauv.] is a grain and forage crop well adapted to nutrient-poor soils. To date little known how FM adapts low nitrogen (LN) at the morphological, physiological, molecular levels. Using variety Yugu1, we found that LN led lower chlorophyll contents N concentrations, higher root/shoot C/N ratios utilization efficiencies under hydroponic culture. Importantly, enhanced biomass accumulation in root was contrast smaller system, as indicated by significant...
Carotenoid cleavage dioxygenases (CCDs) drive carotenoid catabolism to produce various apocarotenoids and immediate derivatives with particular developmental, ecological, agricultural importance. How CCD genes evolved species diversification the resulting functional novelties in cereal crops have remained largely elusive. We constructed a unified four-clade phylogenetic tree of CCDs, revealing previously unanchored basal clade CCD10. CCD10 underwent highly dynamic duplication or loss events,...
Drought resistance in plants is influenced by multiple signaling pathways that involve various transcription factors, many target genes, and types of epigenetic modifications. Studies on modifications drought focus DNA methylation histone modifications, with fewer chromatin remodeling. Changes accessibility can play an important role abiotic stress affecting RNA polymerase binding regulatory factors. However, the changes during apples are not well understood. In this study, landscape...
Astragalin (AG), a typical flavonoid found in Thesium chinense Turcz (T. chinense), is abundant various edible plants and possesses high nutritional value, as well antioxidant antibacterial effects. In this study, we initially predicted the mechanism of action AG with two anti-aging antioxidant-related protein targets (CD38 IGFR) by molecular docking dynamics simulation techniques. Subsequently, examined effects Caenorhabditis elegans (C. elegans), zebrafish, verified related mechanisms. C....
Community detection, which identifies densely connected node clusters with sparse between-group links, is vital for analyzing network structure and function in real-world systems. Most existing community detection methods based on GCNs primarily focus node-level information while overlooking community-level features, leading to performance limitations large-scale networks. To address this issue, we propose LQ-GCN, an overlapping model from a local perspective. LQ-GCN employs...
Article9 October 2020Open Access Transparent process IL-10 producing type 2 innate lymphoid cells prolong islet allograft survival Qingsong Huang Henan Key Laboratory of Immunology and Targeted Drugs, School Medicine, Xinxiang Medical University, Xinxiang, China Search for more papers by this author Xiaoqian Ma Centre Transplant Renal Research, Westmead Institute The University Sydney, NSW, Australia Cell Transplantation Gene Therapy, Third Xiangya Hospital Central South Changsha, Yiping...
Abstract Background New therapies are urgently needed in melanoma particularly late-stage patients not responsive to immunotherapies and kinase inhibitors. Methods Drug screening, IC50 determinations as well synergy assays were detected by the MTT assay. Apoptosis using Annexin V 7AAD staining was assessed flow cytometry. TUNEL performed immunocytochemistry. Changes phosphorylation of key molecules PI3K/Akt/mTOR other relevant pathways western blot To assess vivo anti-tumor activity...
Elucidating key factors that regulate immune-mediated pathology in vivo is critical for developing improved strategies to treat autoimmune disease and cancer. NK cells can exhibit regulatory functions against CD8+ T following viral infection. Here we show while low doses of lymphocytic choriomeningitis virus (LCMV-WE) readily induce strong cell responses diabetes mice expressing the LCMV glycoprotein on -islet (RIP-GP mice), hyperglycemia does not occur after infection with higher LCMV....
Long non-coding RNA (lncRNA) X-inactive specific transcript (XIST) is oncogenic in multiple cancers. Herein, the present study aimed at delving into how XIST functions retinoblastoma (RB) and investigating its underlying mechanism. In this study, XIST, miR-191-5p, BDNF mRNA, expression levels RB tissues or cell lines were examined by quantitative real-time polymerase chain reaction (qRT-PCR) Western blot. The models of gain-of-function loss-of-function established transfection pcDNA3.1-XIST,...
Phosphorus and nitrogen nutrition have profound complicated innate connections; however, underlying molecular mechanisms are mostly elusive. PHR1 is a master phosphate signaling component, whether it directly functions in phosphorus-nitrogen crosstalk remains particularly interesting question. In maize, limitation caused tip kernel abortion ear shortening. By contrast, moderately low the field reduced kernels across ear, maintained elongation significantly lowered concentrations of total...
Objective This study aimed to investigate the prevalence of glaucoma with associated factors in rural populations 10 provinces China. Design A population-based cross-sectional study. Methods All participants aged 6 years or older from completed visual acuity testing, slit-lamp examination, ophthalmoscopy and non-contact tonometry. Glaucoma suspects underwent fundus photography, Goldmann applanation tonometry, field testing gonioscopy. was determined according International Society...
Abstract Malignant bone tumor osteosarcoma (OS) displays high metastasis incidence and poor prognosis. Its stem cell properties could serve to explain recurrence resistance conventional treatments. In this study, we identified UEV1A as a novel suppressor of OS. Elevated diminishes OS cells drives them terminal differentiation. Importantly, -overexpressed delay proliferation are more sensitive chemotherapeutic agents than control cells. Uev1A appears be involved in the BMP signaling pathway...