A5100626727- MicroRNA in disease regulation
- Extracellular vesicles in disease
- Cancer-related molecular mechanisms research
- Membrane-based Ion Separation Techniques
- Fuel Cells and Related Materials
- Blood Coagulation and Thrombosis Mechanisms
- Nanoplatforms for cancer theranostics
- Ubiquitin and proteasome pathways
- RNA modifications and cancer
- Hemophilia Treatment and Research
- COVID-19 epidemiological studies
- Microfluidic and Capillary Electrophoresis Applications
- Circular RNAs in diseases
- RNA Research and Splicing
- Advanced Bandit Algorithms Research
- Cancer-related gene regulation
- Probiotics and Fermented Foods
- Mesenchymal stem cell research
- Gut microbiota and health
- Membrane Separation Technologies
- Microfluidic and Bio-sensing Technologies
- Epigenetics and DNA Methylation
- Auction Theory and Applications
- Fossil Insects in Amber
- Spinal Cord Injury Research
China Pharmaceutical University
2022-2025
China Agricultural University
2025
Zhejiang University of Technology
2023-2025
First Affiliated Hospital of Zhengzhou University
2021-2024
Qingdao University
2024
Affiliated Hospital of Qingdao University
2024
Nanjing Drum Tower Hospital
2016-2024
Nanjing University of Chinese Medicine
2024
Zhejiang A & F University
2021-2024
Institute of Bast Fiber Crops
2024
Nonenzymatic DNA catalytic amplification strategies have greatly benefited bioanalysis. However, long period incubation is usually required due to its relatively low reaction rate and efficiency, which limits in vivo application. Here we design a responsive nano string light (DNSL) by interval hybridization of modified hairpin probe pairs nanowire generated rolling circle realize accelerated cascade (DCR) for fast highly efficient mRNA imaging living cells. Target initiates two paired probes...
Altered expression of microRNAs (miRNAs) is known to contribute cancer progression. miR-23b and miR-27b, encoded within the same miRNA cluster, are reported have both tumor suppressive oncogenic activity across human cancers, including breast cancer.
Dysbiosis leads to continuous progress of inflammatory bowel disease (IBD). However, current therapeutic approaches for IBD have limited efficacy and are associated with various side effects. This study focused on exploring the positive effect a new Bacillus cereus (B. cereus) strain (HMPM18123) in colitis mouse model elucidate underlying molecular mechanisms. The symptoms were alleviated by B. administration as evidenced decreased body weight loss, colon length shortening, activity index...
Black phosphorus (BP) nanostructures with unique layer-dependent properties have been extensively applied in the fields of electronic devices, energy conversion and storage, nanomedicine. As a narrow band gap semiconductor, they are expected to show strong second near-infrared (NIR-II) fluorescence. However, there is no report on NIR-II fluorescence free-standing BP nanostructures, which great potential bioimaging because their excellent biocompatibility biodegradability. Here, for first...
miR-1246 is considered an oncomiR in various cancer types. However, the origin and biogenesis of remain controversial which often leads to misinterpretation its detection biological function, inevitably masking mechanisms action. Using next generation small RNA sequencing, CRISPR-Cas9 knockout, siRNA knockdown poly-A tailing SYBR qRT-PCR, we examined exosomal human cell model systems. We found that highly enriched exosomes derived from cells it originates RNU2-1, a nuclear essential...
Dysfunction of the glymphatic system in brain different stages altered glucose metabolism and its influencing factors are not well characterized.
Topology optimization method is applied to a contraction–expansion structure, based on which simplified lateral flow structure generated using the Boolean operation. A new one-layer mixer then designed by sequentially connecting this and bent channels. The mixing efficiency further optimized via iterations key geometric parameters associated with designed. Numerical results indicate that has better than conventional for wide range of Reynolds number.
BackgroundGait impairment has a major impact on quality of life in patients with Parkinson's disease (PD). It is believed that basal ganglia oscillatory activity at β frequencies (15-30 Hz) may contribute to gait impairment, but the precise dynamics this during remain unclear. Additionally, auditory cues are known lead improvements kinematics PD. If neurophysiological mechanisms cueing effect were better understood they could be leveraged treat impairments using adaptive Deep Brain...
Cucumber (Cucumis sativus L.) is one of the most widely cultivated crops worldwide and valued for its nutritional, economic, ecological benefits. The regulation defense mechanisms against herbivores, along with osmotic loss environmental regulation, greatly affected by trichomes in cucumbers. In this study, we attempted to characterize examined fruit physiological transcriptome profiles RNA sequencing cucumber breeding lines 6101-4 5634-1 at three stages development through foliar...
Overcoming osimertinib resistance in NSCLC treatment remains a significant clinical challenge. CDK9 has emerged as promising target due to its critical role sustaining oncogenic transcriptional programs, particularly via Mcl-1 regulation. Herein, we report the structure-guided optimization of previously identified inhibitor (Z11), resulting discovery T7, potent, selective, and metabolically stable candidate (IC50 = 1.2 nM). T7 effectively suppressed cell proliferation, reduced colony...
The selectivity of dual-side-chain functionalized poly(aryl ether sulfone)-based AIEM for Cl − /SO 4 2− can reach 52.21, outperforming the Neosepta ACS with a 18.63.
NIR-II-triggered phototherapy presents a noninvasive, resistance-free alternative therapeutic approach with deeper tissue penetration and improved imaging of deep tumors. However, many NIR-II phototherapeutic agents suffer from low fluorescence quantum yields, poor photothermal conversion efficiency (PCE), reduced efficacy due to the upregulation heat shock protein HSP70. This study develops small-molecule agent (IRF) high yield (17.4%), excellent PCE (96.8%) for therapy (PTT), photodynamic...
Abstract Recent studies reported that METTL4 regulates DNA 6mA in vivo and therefore is a candidate m6A methyltransfease. However, the enzymatic activity of vitro has not been demonstrated part due to difficulties obtaining well-folded proteins. Here we show mettl4 major methyltransfase responsible for methylation U2 snRNA both fly, identify adenosine at 29th position as site methylation. This study answered long-standing question regarding METTL4, thus paved way further investigating...
Abstract BACKGROUND Sanghuang mushrooms are medicinal fungi widely used in eastern Asia. In this study, the antioxidant and anti‐inflammatory activity of a novel extracellular polysaccharopeptide, sanghuang polysaccharopeptide (SePSP) was investigated. The SePSP purified from submerged fermentation broth mycelium, Sanghuangporus lonicericola strain CBS17, which isolated wild fruiting body. RESULTS extracted using an ethanol precipitation procedure, followed by diethylaminoethanol (DEAE)...
A new genus with a species, Fuscopolystoechotes reticulatus Xu, Zheng, Shih Wang, gen. et sp. nov., and species Lichenipolystoechotes fenestratus Fang, nov. of Ithonidae, are described from the Middle Jurassic Jiulongshan Formation, Inner Mongolia, China. Both assigned to Polystoechotes genus-group mainly based on combination following characters: distinctly narrowed costal space in distal half, presence recurrent humeral veinlet ScA, absence interlinked crossveins between crossveins,...