A5018134307- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Transcranial Magnetic Stimulation Studies
- Neuroscience and Neural Engineering
- Pain Management and Treatment
- Botulinum Toxin and Related Neurological Disorders
- Genetic Neurodegenerative Diseases
- EEG and Brain-Computer Interfaces
- Heart Rate Variability and Autonomic Control
- Pain Mechanisms and Treatments
- Functional Brain Connectivity Studies
- Neural dynamics and brain function
- Neuroscience of respiration and sleep
- Neuroscience and Neuropharmacology Research
- Advanced Neuroimaging Techniques and Applications
- Migraine and Headache Studies
- Musculoskeletal pain and rehabilitation
- Cardiovascular Syncope and Autonomic Disorders
- Vagus Nerve Stimulation Research
- Urinary Bladder and Prostate Research
- Cardiac Arrhythmias and Treatments
- Advanced MRI Techniques and Applications
- Cardiac pacing and defibrillation studies
- Atrial Fibrillation Management and Outcomes
- Sleep and Wakefulness Research
University of Oxford
2016-2025
Nuffield Orthopaedic Centre
2011-2025
John Radcliffe Hospital
2016-2025
Children's Hospital of Philadelphia
2025
Boston University
2025
Surgical Science (Sweden)
2025
Yale University
2024
University of Ottawa
2023-2024
University Medical Center of the Johannes Gutenberg University Mainz
2024
Johannes Gutenberg University Mainz
2024
Objective Brain–computer interfaces (BCIs) could potentially be used to interact with pathological brain signals intervene and ameliorate their effects in disease states. Here, we provide proof‐of‐principle of this approach by using a BCI interpret activity patients advanced Parkinson (PD) use feedback control when therapeutic deep stimulation (DBS) is delivered. Our goal was demonstrate that personalizing optimizing real time, improve on both the efficacy efficiency conventional continuous...
Despite the success of catheter ablation for treatment idiopathic ventricular tachycardia (VT), occasional patients have been reported in whom VT could not be ablated from right or left endocardium aortic sinus Valsalva (ASOV).In 12 138 (9%) with referred ablation, an epicardial site origin was identified >10 mm ASOV. Coronary venous mapping demonstrated preceding endocardial activation by ms (41+/-7 versus 15+/-11 before QRS onset; P<0.001). induction facilitated catecholamines and...
Lung squamous cell carcinoma (LSCC) remains a leading cause of cancer death with few therapeutic options. We characterized the proteogenomic landscape LSCC, providing deeper exposition LSCC biology potential implications. identify NSD3 as an alternative driver in FGFR1-amplified tumors and low-p63 overexpressing target survivin. SOX2 is considered undruggable, but our analyses provide rationale for exploring chromatin modifiers such LSD1 EZH2 to SOX2-overexpressing tumors. Our data support...
See Moll and Engel (doi:10.1093/aww308) for a scientific commentary on this article. Brain regions dynamically engage disengage with one another to execute everyday actions from movement decision making. Pathologies such as Parkinson’s disease tremor emerge when brain controlling cannot readily decouple, compromising motor function. Here, we propose novel stimulation strategy that selectively regulates neural synchrony through phase-specific stimulation. We demonstrate the first time...
High-amplitude beta band oscillations within the subthalamic nucleus are frequently associated with Parkinson's disease but it is unclear how they might lead to motor impairments. Here we investigate a likely pathological coupling between phase of and amplitude high-frequency around 300 Hz.We analysed an extensive data set comprising resting-state recordings obtained from deep brain stimulation electrodes in 33 patients before and/or after taking dopaminergic medication. We correlated mean...
Darwin originally pointed out that there is something about infants which prompts adults to respond and care for them, in order increase individual fitness, i.e. reproductive success, via increased survivorship of one's own offspring. Lorenz proposed it the specific structure infant face serves elicit these parental responses, but biological basis this remains elusive. Here, we investigated whether show brain responses unfamiliar faces compared adult faces, where had been carefully matched...
Our aim was to asses the efficacy of deep brain stimulation in post-stroke neuropathic pain. Since 2000, 15 patients with intractable pain were treated periventricular gray area (PVG), sensory thalamus (Ventroposterolateral nucleus-VPL) or both. Pain assessed using both a visual analogue scale and McGill's questionnaire. VAS scores show mean improvement 48.8% (SD 8.6%). However, there is wide variation between patients. This study demonstrates that it an effective treatment 70% such
The pedunculopontine nucleus, a component of the reticular formation, is topographically organized in animal models and implicated locomotor control. In Parkinson's disease, nucleus stimulation an emerging treatment for gait freezing. Local field potentials recorded from electrodes such patients have demonstrated oscillations alpha beta frequency bands, reactive to self-paced movement. Whether these are or relevant locomotion unknown. Here, we local parkinsonian during rest unconstrained...
BACKGROUND: Deep brain stimulation (DBS) to treat neuropathic pain refractory pharmacotherapy has reported variable outcomes and gained United Kingdom but not USA regulatory approval. OBJECTIVE: To prospectively assess long-term efficacy of DBS for chronic in a single-center case series. METHODS: Patient outcome measures were collated before after surgery, using visual analog score, short-form 36-question quality-of-life survey, McGill questionnaire, EuroQol-5D questionnaires (EQ-5D health...
The subthalamic nucleus (STN) is a key node in the network that supports response inhibition. It suggested STN rapidly inhibits basal ganglia activity, to pause motor output during conflict until an appropriate plan ready. Here, we recorded neural activity Stroop task from deep brain stimulation electrodes implanted human STN. We intended determine whether cognitive psychological phenomena such as effect can be explained via mechanisms of inhibition involving STN, or higher centers are alone...
Considerable evidence suggests a role of beta-band oscillations in voluntary movements. However, most the studies linking beta power to motor performance are based on data averaged across trials that ignore fast dynamics oscillatory activity and trial-to-trial variations responses. Recently, emphasis has shifted from functional implications mean presence nature episodic bursts activity. Here we test hypothesis bursts, though short duration more physiological state, may help explain...
The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has a international shortage of the nasopharyngeal swabs that are required for collection optimal specimens, creating critical bottleneck blocking clinical laboratories’ ability to perform high-sensitivity virological testing SARS-CoV-2. To address this crisis, we designed and executed an innovative, cooperative, rapid-response translational-research program brought together health care workers,...
Deep brain stimulation (DBS) has shown considerable promise for relieving nociceptive and neuropathic symptoms of refractory chronic pain. Nevertheless, some patients, standard DBS pain remains poorly efficacious. Pain is a multidimensional experience with an affective component: the unpleasantness. The anterior cingulate cortex (ACC) structure involved in this component, targeting it may relieve patients' pain.To describe first case series ACC to component pain.Sixteen patients (13 male 3...
The subthalamic nucleus (STN) is thought to play a central role in modulating responses during conflict. Computational models have suggested that the location of STN basal ganglia, as well its numerous connections conflict-related cortical structures, allows it be ideally situated act global inhibitor Additionally, recent behavioral experiments shown deep brain stimulation results impulsivity high-conflict situations. However, precise mechanisms mediate “hold-your-horses” function remain...
Background Positive clinical outcomes are now well established for deep brain stimulation, but little is known about the effects of long-term stimulation on structural and functional connectivity. Here, we used rare opportunity to acquire pre- postoperative diffusion tensor imaging in a patient undergoing bilateral subthalamic nuclei Parkinson's Disease. This allowed us analyse differences connectivity before after stimulation. Further, computational model spontaneous activity was estimate...
Optimal decision-making requires balancing fast but error-prone and more accurate slower decisions through adjustments of decision thresholds. Here, we demonstrate two distinct correlates such speed-accuracy by recording subthalamic nucleus (STN) activity electroencephalography in 11 Parkinson’s disease patients during a perceptual task; STN low-frequency oscillatory (LFO) (2–8 Hz), coupled to at prefrontal electrode Fz, beta (13–30 Hz) electrodes C3/C4 close motor cortex. These differed not...
Deep brain stimulation (DBS) for Parkinson's disease is a highly effective treatment in controlling otherwise debilitating symptoms. Yet the underlying mechanisms are currently not well understood. Whole-brain computational modeling was used to disclose effects of DBS during resting-state functional Magnetic Resonance Imaging ten patients with disease. Specifically, we explored local and global impact that has creating asynchronous, stable or critical oscillatory conditions using...
Abstract Background High‐frequency thalamic stimulation is an effective therapy for essential tremor, which mainly affects voluntary movements and/or sustained postures. However, continuous may deliver unnecessary current to the brain due intermittent nature of tremor. Objective We proposed close loop by detecting tremor‐provoking movement states using local field potentials recorded from same electrodes implanted stimulation, so that only delivered when necessary. Methods Eight patients...
OBJECTIVE The effectiveness and optimal stimulation site of deep brain (DBS) for central poststroke pain (CPSP) remain elusive. objective this retrospective international multicenter study was to assess clinical as well neuroimaging-based predictors long-term outcomes after DBS CPSP. METHODS authors analyzed patient-based neuroimaging data previously published unpublished cohorts from 6 centers. leads were reconstructed normalized. A map constructed on the basis individual settings...