A5034385830- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Advanced Neuroimaging Techniques and Applications
- Functional Brain Connectivity Studies
- Neuroscience and Neuropharmacology Research
- Cerebrospinal fluid and hydrocephalus
- Neural dynamics and brain function
- EEG and Brain-Computer Interfaces
- Alzheimer's disease research and treatments
- Obsessive-Compulsive Spectrum Disorders
- Memory and Neural Mechanisms
- Genetic Neurodegenerative Diseases
- Neurotransmitter Receptor Influence on Behavior
- Transcranial Magnetic Stimulation Studies
- Reading and Literacy Development
- Neural and Behavioral Psychology Studies
- Nicotinic Acetylcholine Receptors Study
- Advanced MRI Techniques and Applications
- Neuroscience and Neural Engineering
- Dementia and Cognitive Impairment Research
- Brain Tumor Detection and Classification
- Cholinesterase and Neurodegenerative Diseases
- Balance, Gait, and Falls Prevention
- Traumatic Brain Injury and Neurovascular Disturbances
- Children's Physical and Motor Development
Manchester Metropolitan University
2017-2025
Barcelonaβeta Brain Research Center
2023
Brain (Germany)
2023
University of Oxford
2005-2019
King's College London
2014-2017
Scope
2014
Centre for Addiction and Mental Health
2010-2013
University of Toronto
2010-2013
Toronto Western Hospital
2010-2013
University Health Network
2011-2012
See Gratwicke and Foltynie (doi:10.1093/brain/awx333) for a scientific commentary on this article.Cognitive impairments are prevalent disabling non-motor complication of Parkinson's disease, but with variable expression progression. The onset serious cognitive decline occurs alongside substantial cholinergic denervation, imprecision previously available techniques in vivo measurement degeneration limit their use as predictive biomarkers. However, recent developments stereotactic mapping the...
The pedunculopontine nucleus is composed of cholinergic and non-cholinergic neurones located in the caudal pontomesencephalic tegmentum. Evidence suggests that plays a role production control movement. has dense interconnections with basal ganglia, as well other areas brain associated motor control. Electrical stimulation decerebrate cat or rat produces organized locomotor movements. Physiological studies show modulates its activity response to locomotion, voluntary arm eye Degeneration seen...
The subthalamic nucleus (STN) is a key node in the network that supports response inhibition. It suggested STN rapidly inhibits basal ganglia activity, to pause motor output during conflict until an appropriate plan ready. Here, we recorded neural activity Stroop task from deep brain stimulation electrodes implanted human STN. We intended determine whether cognitive psychological phenomena such as effect can be explained via mechanisms of inhibition involving STN, or higher centers are alone...
Abstract The control of impulse behavior is a multidimensional concept subdivided into separate subcomponents, which are thought to represent different underlying mechanisms due either disinhibitory processes or poor decision‐making. In patients with Parkinson's disease (PD), dopamine‐agonist (DA) therapy has been associated increased impulsive behavior. However, the relationship among these components in and role DA not well understood. this imaging study, we investigated PD effects...
The cholinergic basal forebrain (CBF), comprising different groups of cortically projecting neurons, plays a crucial role in higher cognitive processes and has been implicated diverse neuropsychiatric disorders. A distinct corticotopic organization CBF projections revealed animal studies, but little is known about their the human brain. We explored regional differences functional connectivity (FC) profiles within by applying clustering approach to resting-state magnetic resonance imaging...
Abstract Patients who have dementia with Lewy bodies and Alzheimer’s disease show early degeneration of the cholinergic nucleus basalis Meynert. However, how white matter projections between Meynert cortex are altered in neurodegenerative is unknown. Tractography pathways originating from was performed using diffusion-weighted imaging 46 patients dementia, 48 bodies, 35 mild cognitive impairment disease, 38 71 control participants. Mean diffusivity resulting compared groups related to...
Degeneration of cortical cholinergic projections from the nucleus basalis Meynert (NBM) is characteristic dementia with Lewy bodies (DLB) and Alzheimer's disease (AD), whereas involvement pedunculopontine (PPN) to thalamus less clear.We studied both projection systems using a free water-corrected diffusion tensor imaging (DTI) model in following cases: 46 AD, 48 DLB, 35 mild cognitive impairment (MCI) 38 MCI bodies, 71 controls.Free water NBM-cortical pathway was increased groups compared...
Structural imaging of the cholinergic basal forebrain may provide a biomarker for system integrity that can be used in motor and non-motor outcome studies Parkinson's disease. However, no prior have validated these structural metrics with nerve terminal vivo Here, we correlate morphometry topography vesicular acetylcholine transporter large sample.
The main pattern of cognitive impairments seen in early to moderate stages Parkinson's disease (PD) includes deficits executive functions. These nonmotor complications have a significant impact on the quality life and day-to-day activities PD patients are not effectively managed by current therapies, problem which is almost certainly due fact that extends beyond nigrostriatal system. To investigate role extrastriatal dopamine function PD, control group were studied with...
The recently discovered glymphatic system may support the removal of neurotoxic proteins, mainly during sleep, that are associated with neurodegenerative diseases such as Alzheimer's and Parkinson's Disease. Diffusion tensor image analysis along perivascular space (DTI-ALPS) has been suggested a method to index health (with higher values indicating more intact system). Indeed, in small-scale studies DTI-ALPS shown correlate age, cognitive health, is females than males. To determine whether...
The emerging evidence of the role glymphatic system (GS) in Alzheimer's disease (AD) provides new opportunities for intervention from earliest stages disease. aim study is to evaluate efficacy GS AD identify biomarkers. We performed a two-stage proteomic health using intravenous gadolinium-based contrast agent (GBCA) with serial T1 3T magnetic resonance imaging (MRI) individuals amnestic mild cognitive impairment (aMCI). In Stage 1 (evaluated Cohort aMCI participants (n = 11)), we correlated...
Blood pressure (BP) physiologically dips during sleep, and lack of dipping associates with adverse health outcomes cognitive decline. Vascular pulsatility is the main driver glymphatic cerebrospinal fluid transport, which removes metabolic waste products from brain sleep. We hypothesized that abnormal sleep BP patterns may affect system health, this relationship result in lower diffusion tensor imaging along perivascular spaces (DTI-ALPS) indices, a proposed neuroimaging index health....
The magnocellular system plays an important role in visual motion processing, controlling vergence eye movements, and reading. Yellow filters may boost activity by eliminating inhibitory blue input to this pathway. It was found that wearing yellow increased sensitivity, convergence, accommodation many children with reading difficulties, both immediately after three months using the filters. Motion sensitivity not control neutral density Moreover, reading-impaired showed significant gains...
Developmental dyslexia is diagnosed when children fail to acquire literacy skills despite adequate education and intellectual ability. There evidence of impaired implicit learning in dyslexia, it possible that poor dyslexic affects their acquisition complex such as reading. To assess whether with show motor learning, 45 completed a serial reaction time task (SRTT). Age‐matched controls ( n = 44) nondyslexic readers (“garden‐variety” readers, 20) were used comparison groups. The inclusion the...