A5064492892- Functional Brain Connectivity Studies
- Alzheimer's disease research and treatments
- Neural dynamics and brain function
- Musculoskeletal pain and rehabilitation
- Olfactory and Sensory Function Studies
- Smoking Behavior and Cessation
- Pain Mechanisms and Treatments
- Dementia and Cognitive Impairment Research
- Memory and Neural Mechanisms
- Nicotinic Acetylcholine Receptors Study
- Fibromyalgia and Chronic Fatigue Syndrome Research
German Center for Neurodegenerative Diseases
2018-2020
University of Rostock
2018-2020
Universitätsmedizin Greifswald
2014-2015
The cholinergic basal forebrain (CBF), comprising different groups of cortically projecting neurons, plays a crucial role in higher cognitive processes and has been implicated diverse neuropsychiatric disorders. A distinct corticotopic organization CBF projections revealed animal studies, but little is known about their the human brain. We explored regional differences functional connectivity (FC) profiles within by applying clustering approach to resting-state magnetic resonance imaging...
Dysfunction of the cholinergic basal forebrain (cBF) is associated with cognitive decline in Alzheimer's disease (AD). Multimodal MRI allows for investigation cBF changes in-vivo. In this study we assessed alterations functional connectivity (FC), mean diffusivity (MD), and volume across spectrum AD. We further effects amyloid pathology on these changes. Participants included healthy controls, subjects subjective (SCD), mild impairment (MCI), or AD dementia (ADD) from multicenter DELCODE...