A5016338164- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Neurological disorders and treatments
- Olfactory and Sensory Function Studies
- Biochemical Analysis and Sensing Techniques
- Neural dynamics and brain function
- Advanced Chemical Sensor Technologies
- Botulinum Toxin and Related Neurological Disorders
- Mental Health Research Topics
- Bipolar Disorder and Treatment
- Regulation of Appetite and Obesity
- Nonlinear Dynamics and Pattern Formation
- Parkinson's Disease Mechanisms and Treatments
- Neurobiology and Insect Physiology Research
- Bioinformatics and Genomic Networks
- Topological and Geometric Data Analysis
- Traumatic Brain Injury Research
- Neural and Behavioral Psychology Studies
- Pain Management and Treatment
- Treatment of Major Depression
- Pain Mechanisms and Treatments
- EEG and Brain-Computer Interfaces
- Genetic Neurodegenerative Diseases
- Multisensory perception and integration
- Eating Disorders and Behaviors
Aarhus University
2012-2019
University of Oxford
2012-2019
Aarhus University Hospital
2018-2019
Royal Academy of Music
2016-2019
Warneford Hospital
2016-2019
Oxford Research Group
2016
American Academy of Child and Adolescent Psychiatry
2015
University of Cambridge
2014
During rest, envelopes of band-limited on-going MEG signals co-vary across the brain in consistent patterns, which have been related to resting-state networks measured with fMRI. To investigate genesis such envelope correlations, we consider a whole-brain network model assuming two distinct fundamental scenarios: one where each area generates oscillations single frequency, and novel can generate multiple frequency bands. The models share, as common generator damped oscillations, normal form...
Deep brain stimulation (DBS) has shown considerable promise for relieving nociceptive and neuropathic symptoms of refractory chronic pain. Nevertheless, some patients, standard DBS pain remains poorly efficacious. Pain is a multidimensional experience with an affective component: the unpleasantness. The anterior cingulate cortex (ACC) structure involved in this component, targeting it may relieve patients' pain.To describe first case series ACC to component pain.Sixteen patients (13 male 3...
Background Positive clinical outcomes are now well established for deep brain stimulation, but little is known about the effects of long-term stimulation on structural and functional connectivity. Here, we used rare opportunity to acquire pre- postoperative diffusion tensor imaging in a patient undergoing bilateral subthalamic nuclei Parkinson's Disease. This allowed us analyse differences connectivity before after stimulation. Further, computational model spontaneous activity was estimate...
Deep brain stimulation (DBS) for Parkinson's disease is a highly effective treatment in controlling otherwise debilitating symptoms. Yet the underlying mechanisms are currently not well understood. Whole-brain computational modeling was used to disclose effects of DBS during resting-state functional Magnetic Resonance Imaging ten patients with disease. Specifically, we explored local and global impact that has creating asynchronous, stable or critical oscillatory conditions using...
Abstract Neurobiological models to explain vulnerability of major depressive disorder (MDD) are scarce and previous functional magnetic resonance imaging studies mostly examined “static” connectivity (FC). Knowing that FC constantly evolves over time, it becomes important assess how dynamically differs in remitted‐MDD patients vulnerable for new episodes. Using a recently developed method examine dynamic FC, we characterized re‐emerging states during rest 51 antidepressant‐free MDD at high...
Abstract Olfactory deficits are a common (often prodromal) symptom of neurodegenerative or psychiatric disorders. As such, olfaction could have great potential as an early biomarker disease, for example using neuroimaging to investigate the breakdown structural connectivity profile primary olfactory networks. We investigated suitability this purpose in two existing maps found problems with both terms their known secondary Based on these findings, we were able merge new template map networks...
Deep brain stimulation (DBS) has shown promise for relieving nociceptive and neuropathic symptoms of refractory chronic pain. We assessed the efficacy a new target affective component pain, anterior cingulate cortex (ACC). A 49-year-old man with pain underwent bilateral ACC DBS. Patient-reported outcome measures were collected before 2 years after surgery using Visual Analogue Scale, Short-Form 36 quality life survey, McGill questionnaire, EuroQol-5D questionnaires (EQ-5D; Health State)...
The neuropathology of schizophrenia remains unclear. Some insight has come from modern neuroimaging techniques, which offer an unparalleled opportunity to explore in vivo the structure and function brain. Using functional magnetic resonance imaging, it been found that large-scale resting-state connectivity (rsFC) — measured as temporal correlations blood-oxygen-level-dependent (BOLD) signal exhibit altered network topology, with lower small-world index. origin these rsFC alterations link...
Intrinsic brain activity is characterized by highly organized co-activations between different regions, forming clustered spatial patterns referred to as resting-state networks. The observed co-activation are sustained the intricate fabric of millions interconnected neurons constituting brain's wiring diagram. However, for other real networks, relationship connectional structure and emergent collective dynamics still evades complete understanding. Here, we show that it possible estimate...
In recent years, the application of network analysis to neuroimaging data has provided useful insights about brain's functional and structural organization in both health disease. This proven a significant paradigm shift from study individual brain regions isolation. Graph-based models consist vertices, which represent distinct areas, edges encode presence (or absence) or relationship between each pair vertices. By definition, any graph metric will be defined upon this dyadic representation...
Abstract Adult ADHD has been linked to impaired motor response inhibition and reduced associated activation in the right inferior frontal cortex (IFC). However, it is unclear whether abnormal adult specifically related a deficit or reflects more general attentional processing. Using functional magnetic resonance imaging, we tested group of 19 patients with no comorbidities healthy control volunteers on modified go/no‐go task that shown previously distinguish between cortical responses...
Crying is the most salient vocal signal of distress. The cries a newborn infant alert adult listeners and often elicit caregiving behavior. For parent, rapid responding to an in distress adaptive behavior, functioning ensure offspring survival. ability react rapidly requires quick recognition evaluation stimuli followed by co-ordinated motor response. Previous neuroimaging research has demonstrated early specialized activity response faces. Using magnetoencephalography, we found similarly...
The Sniffin' Sticks 12-identification test (SIT-12) is the most commonly applied Danish olfaction screening tool; however, it has never been validated in a population. score depends on familiarity with descriptors, which strongly influenced by linguistic and cultural factors, why validation mandatory. This study aimed to validate SIT-12 population.Prospective controlled study.Otorhinolaryngology department.The was 100 normosmic, healthy adult participants.Choice of descriptors registered,...
Abstract Bipolar disorder (BD) has been linked to disrupted structural and functional connectivity between prefrontal networks limbic brain regions. Studies of patients with pediatric bipolar (PBD) can help elucidate the developmental origins altered underlying BD provide novel insights into aetiology BD. Here we compare network properties whole-brain connectomes euthymic PBD psychosis, a variant PBD, matched healthy controls. Our results show widespread changes in psychosis both cortical...
Deep brain stimulation (DBS) is a remarkably effective clinical tool, used primarily for movement disorders. DBS relies on precise targeting of specific regions to rebalance the oscillatory behaviour whole-brain neural networks. Traditionally, has been based upon animal models (such as MPTP Parkinson's disease) but also result serendipity during human lesional neurosurgery. There are, however, no good psychiatric disorders such depression and schizophrenia, progress in this area slow. In...
It is unclear whether Hebbian-like learning occurs at the level of long-range white matter connections in humans, i.e., where measurable changes structural connectivity (SC) are correlated with functional connectivity. However, behavioral observed after deep brain stimulation (DBS) suggest existence such mechanisms occurring consequences. In this rare case study, we obtained full network one patient Parkinson's disease (PD) before and long-term DBS combined it a computational model ongoing...
The brain operates at a critical point that is balanced between order and disorder. Even during rest, unstable periods of random behavior are interspersed with stable activity patterns support optimal information processing. Being born preterm may cause deviations from this normal pattern development. We compared 33 extremely (EPT) children < 27 weeks gestation 28 full-term controls. Two approaches were adopted in both groups, when they 10 years age, using structural functional magnetic...