The aim of the present study was to seek evidence a relationship between damage optic radiation (OR) in immature brain and subsequent development retinal nerve fiber layer (RNFL) associated visual manifestations.Seven cases (2 males 5 females ranging age from 18 35 years old) were selected large cohort individuals with known white matter immaturity (WMDI), who had presented dysfunction. They underwent magnetic resonance imaging (MRI), including diffusion-weighted MRI. Visual function...

Diffusion MRI improves detection of abnormalities in white matter tracts cerebral palsy (CP). Relationships between diffusion measurements and hand function are largely unexplored. We aimed first to assess microstructure corticofugal fibers, second explore associations tract injury as assessed by quantitative analysis children with unilateral CP. <h3>Methods:</h3> In this cross-sectional study, 15 CP (6 boys, median age 12.4 years, min 7.2, max 17) 24 controls were included (9 12.7 8.8,...

The brain operates at a critical point that is balanced between order and disorder. Even during rest, unstable periods of random behavior are interspersed with stable activity patterns support optimal information processing. Being born preterm may cause deviations from this normal pattern development. We compared 33 extremely (EPT) children < 27 weeks gestation 28 full-term controls. Two approaches were adopted in both groups, when they 10 years age, using structural functional magnetic...

<h3>BACKGROUND AND PURPOSE:</h3> Diffusion-weighted MR imaging and fiber tractography can be used to investigate alterations in white matter tracts patients with early acquired brain lesions cerebral palsy. Most existing studies have diffusion tensor tractography, which is limited areas of complex structures or pathologic processes. We explored a combined normalization probabilistic fiber-tracking method for more realistic this patient group. <h3>MATERIALS METHODS:</h3> This cross-sectional...

Preoperative radiological assessment of meningioma characteristics is value for pre- and post-operative patient management, counselling, surgical approach.To investigate whether tensor-valued diffusion MRI can add to the preoperative prediction consistency, grade type.30 patients with intracranial meningiomas (22 WHO I, 8 II) underwent prior surgery. Diffusion was performed linear spherical b-tensors b-values up 2000 s/mm2. The data were used estimate mean diffusivity (MD), fractional...

In this paper, we quantify the degree of ganglion cell layer thinning due to retrograde trans-synaptic degeneration (RTSD) from retro-geniculate damage in six cases who had homonymous visual field defects known since childhood. Three prenatal injuries, occurring close mid-gestation and first parts early late third trimester, respectively, representing injuries at different developmental stages. later acquired age 1.5, 4 13 years. The impact injury optic radiations was revealed by fibre...

The aim of this study was to evaluate the use optical coherence tomography (OCT) identify and assess visual field defects caused by primary damage optic radiation in individuals with spastic cerebral palsy (CP). Ten CP (six females, four males, a median age 21 years [range 17–38y]) had their brain lesions documented conventional magnetic resonance imaging (MRI) diffusion‐weighted MRI fibre tractography. Their macular ganglion cell layer (GCL) inner plexiform (IPL) were examined OCT fields...

Histopathology is the gold standard for analysis of atherosclerotic plaques but has drawbacks due to destructive nature method. Ex vivo MRI a non-destructive method image whole plaques. Our aim was use quantitative high field ex classify plaque components, with histology as standard. Surgically resected carotid from 12 patients recent TIA or stroke were imaged at 11.7 T MRI. Quantitative T1/T2* mapping sequences and qualitative gradient echo voxel size 30 × 60 μm3 obtained prior histological...

Neonates with critical congenital heart defects undergoing open-heart surgery on cardiopulmonary bypass circulation are at risk for white matter brain injury. This article reports pre- and postoperative plasma concentrations of injury markers glial fibrillary acidic protein (GFAP), neurofilament light (NfL) Tau, their respective associations lesions detected postoperatively performed MRI. Forty term newborns isolated were included in a prospective observational study. Brain marker determined...

Injuries to the immature optic radiation are associated with thinning of retinal nerve fibre layer and corresponding visual field defects. The aim current study was seek evidence for causal retrograde trans-synaptic degeneration by exploring correspondence between localization extension injury structure macular ganglion cell complex, relation function. Seven adults (age range 18-35) dysfunction secondary white-matter damage immaturity six healthy 22-33) underwent MRI. Fibre tractography used...

To increase the understanding of relationship between structure and function in individuals with damage to brain from different stages maturation visual system, we examined 16 teenagers young adults. We used diffusion-weighted magnetic resonance imaging (MRI) fiber tractography optic radiation (OR) optical coherence tomography (OCT) peripapillary retinal nerve layer (pRNFL) ganglion cell + inner plexiform (GC+IPL) macula. Visual field (VF) was assessed Humphrey Field Analyzer (HFA). Injuries...

Introduction: Diffusion-weighted magnetic resonance imaging (MRI) and fiber tractography are increasingly used to investigate alterations in white matter tracts cerebral palsy (CP). We employed a combined normalization probabilistic fiber-tracking method of the corticospinal (CST) thalamocortical projections primary sensory cortices (TRS1) patients with unilateral CP focal brain lesions.

We describe the case of a 30-year-old woman, who needed formal report on her visual impairment to seek support from society. She was born preterm, and during neonatal period, she suffered bilateral intraventricular hemorrhage (IVH) grade 3, condition that can cause cerebral (CVI) due damage retro-geniculate pathways. Individuals with such brain this severity are often restricted by palsy (CP) intellectual disability, thus have limited ability cooperate in assessment function. However, our...

This study aims to develop quantitative MRI measures that are more statistically straightforward correlate with clinical disability of progressive MS individuals, whose brains often show atrophy and tissue damage vary amongst regions, which is hard interpret clinically. The impacts different software packages MR contrasts on estimating brain were investigated. Individual DTI profiles characterised specific progression within each region, preserving the heterogeneity individuals. Some shown...