A5035375035- Digital Mental Health Interventions
- Mobile Health and mHealth Applications
- Mental Health Research Topics
- Functional Brain Connectivity Studies
- Treatment of Major Depression
- Physical Activity and Health
- Behavioral Health and Interventions
- Impact of Technology on Adolescents
- Child and Adolescent Psychosocial and Emotional Development
- Tryptophan and brain disorders
- COVID-19 and Mental Health
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Obesity, Physical Activity, Diet
- Social Media in Health Education
- Stress Responses and Cortisol
- Child Development and Digital Technology
- Cardiac Health and Mental Health
- Cultural Competency in Health Care
- Innovative Human-Technology Interaction
- Eating Disorders and Behaviors
- Mindfulness and Compassion Interventions
- Diet and metabolism studies
- Neural and Behavioral Psychology Studies
- Statistical Methods in Clinical Trials
- Neural dynamics and brain function
University of California, Berkeley
2019-2025
Delft University of Technology
2023-2025
University of Michigan
2024
University Medical Center Utrecht
2022-2023
University of Amsterdam
2015-2021
Amsterdam UMC Location University of Amsterdam
2013-2021
Amsterdam University Medical Centers
2018-2021
University of Washington
2021
National Cancer Institute
2021
VA Connecticut Healthcare System
2021
OPINION article Front. Psychiatry, 03 June 2020Sec. Public Mental Health Volume 11 - 2020 | https://doi.org/10.3389/fpsyt.2020.00523
Abstract Neurobiological models to explain vulnerability of major depressive disorder (MDD) are scarce and previous functional magnetic resonance imaging studies mostly examined “static” connectivity (FC). Knowing that FC constantly evolves over time, it becomes important assess how dynamically differs in remitted‐MDD patients vulnerable for new episodes. Using a recently developed method examine dynamic FC, we characterized re‐emerging states during rest 51 antidepressant‐free MDD at high...
Introduction Depression and diabetes are highly disabling diseases with a high prevalence rate of comorbidity, particularly in low-income ethnic minority patients. Though comorbidity increases the risk adverse outcomes mortality, most clinical interventions target these separately. Increasing physical activity might be effective to simultaneously lower depressive symptoms improve glycaemic control. Self-management apps cost-effective, scalable easy access treatment increase activity....
One of the core symptoms major depressive disorder is anhedonia, an inability to experience pleasure. In patients with disorder, a dysfunctional reward-system may exist, blunted temporal difference reward-related learning signals in ventral striatum and increased difference-related (dopaminergic) activation tegmental area. Anhedonia often remains as residual symptom during remission; however, it largely unknown whether abovementioned reward systems are still when remission. We used Pavlovian...
Major depressive disorder (MDD) is a burdensome disease that has high risk of relapse/recurrence. Cognitive reactivity appears to be factor for relapse. It remains unclear, however, whether dysfunctional cognitions alone or the such mild states sadness (ie, cognitive reactivity) crucial increases relapse risk. We aimed assess long-term predictive value versus and other factors relapse.In prospective cohort outpatients (N = 116; studied between 2000-2005) who had experienced ≥ 2 previous...
Rumination and cognitive reactivity (dysfunctional cognitions after sad mood-induction) remain high in remitted Major Depressive Disorder (MDD) can contribute to new episodes. These factors have been linked increased fMRI resting-state functional-connectivity within the Default-Mode Network (DMN). It remains unclear whether (I) DMN-connectivity persists during MDD-remission, (II) mood-induction differentially affects remitted-MDD vs controls. Moreover, studies were previously confounded by...
An interesting factor explaining recurrence risk in Major Depressive Disorder (MDD) may be neuropsychological functioning, i.e. processing of emotional stimuli/information. Negatively biased stimuli/information has been found both acute and (inconclusively) remitted states MDD, causally related to depression. We aimed investigate self-referent, memory interpretation biases recurrently depressed patients remission relate these recurrence. included 69 recurrent MDD-patients (rrMDD-patients),...
Low physical activity is an important risk factor for common and mental disorders. Physical interventions delivered via smartphones can help users maintain increase activity, but outcomes have been mixed.Here we assessed the effects of sending daily motivational feedback text messages in a microrandomized clinical trial on changes from one day to next student population.We included 93 participants who used app, "DIAMANTE" period 6 weeks. Every day, their phone pedometer passively tracked...
Background The COVID-19 pandemic has propelled patient-facing research to shift digital and telehealth strategies. If these strategies are not adapted for minority patients of lower socioeconomic status, health inequality will further increase. Patient-centered models care can successfully improve access experience patients. Objective This study aims present the development process preliminary acceptability altering in-person onboarding procedures into internet-based, remote a mobile...
Digital health, the use of apps, text-messaging, and online interventions, can revolutionize healthcare make care more equitable. Currently, digital health interventions are often not designed for those who could benefit most may have unintended consequences. In this paper, we explain how privacy vulnerabilities power imbalances, including racism sexism, continue to influence app design research. We provide guidelines researchers design, report evaluate studies maximize social justice in...
Abstract Recurrent major depressive disorder (rMDD) is a relapsing-remitting disease with high morbidity and 5-year risk of recurrence up to 80%. This was prospective pilot study examine the potential diagnostic prognostic value targeted plasma metabolomics in care patients rMDD remission. We used an established LC-MS/MS platform measure 399 metabolites 68 subjects ( n = 45 females 23 males ) antidepressant-free remission 59 age- sex-matched controls 40 19 males). Patients were then followed...
As intelligent systems become more integrated into people’s daily life, designed to facilitate lifestyle and behavior change for health well-being have also common. Previous work has identified challenges in the development deployment of such AI-based support diabetes management shown that it is necessary shift design process towards a human-centered approach can be addressed by hybrid intelligence (HI). However, this means adopting user-centric process, which brings its own terms...
Introduction Major depressive disorder (MDD) is widely prevalent and severely disabling, mainly due to its recurrent nature. A better understanding of the mechanisms underlying MDD-recurrence may help identify high-risk patients improve preventive treatment they need. has been considered from various levels perspective including symptomatology, affective neuropsychology, brain circuitry endocrinology/metabolism. However, limited, because these perspectives have studied in isolation,...
Insufficient response to treatment is the main cause of prolonged suffering from major depressive disorder (MDD). Early identification insufficient could result in faster and more targeted strategies reduce suffering. We therefore explored whether baseline alterations within between resting state functional connectivity networks serve as markers antidepressant two years follow-up. selected MDD patients (N = 17) NEtherlands Study Depression Anxiety (NESDA), who received ≥ antidepressants,...
Social distancing and stay-at-home orders are critical interventions to slow down person-to-person transmission of COVID-19. While these societal changes help contain the pandemic, they also have unintended negative consequences, including anxiety depression. We developed StayWell, a daily skills-based SMS text messaging program, mitigate COVID-19-related depression symptoms among people who speak English Spanish in United States.This paper describes StayWell participants' levels after 60...
Each year almost 800.000 people die from suicide, of which up to 87% are affected by major depressive disorder (MDD). Despite the strong association between suicidality and MDD, it remains unknown if suicidal symptoms during remission put remitted recurrent MDD patients (rrMDD) at risk for recurrence.At baseline we compared sociodemographic characteristics in un-medicated rrMDD participants matched never-depressed controls. We used HDRS17 IDS-SR30 assess symptomatology. Next, studied...