A5043470118- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Immune cells in cancer
- Immunotherapy and Immune Responses
- IL-33, ST2, and ILC Pathways
- Immune Response and Inflammation
- Immunodeficiency and Autoimmune Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Psoriasis: Treatment and Pathogenesis
- Diabetes and associated disorders
- Adenosine and Purinergic Signaling
- Parkinson's Disease Mechanisms and Treatments
- Cancer Immunotherapy and Biomarkers
- Cytomegalovirus and herpesvirus research
- Tryptophan and brain disorders
- Amyotrophic Lateral Sclerosis Research
- Endoplasmic Reticulum Stress and Disease
- Sulfur Compounds in Biology
- Macrophage Migration Inhibitory Factor
- Inflammasome and immune disorders
- Reproductive System and Pregnancy
- Hepatitis B Virus Studies
- Cancer, Hypoxia, and Metabolism
- Cytokine Signaling Pathways and Interactions
- Adipokines, Inflammation, and Metabolic Diseases
Luxembourg Institute of Health
2017-2024
University of Luxembourg
2018-2024
Heinrich Heine University Düsseldorf
2011-2020
Odense University Hospital
2018
University of Southern Denmark
2018
Zero to Three
2014
Infections with HIV, hepatitis B virus, and C virus can turn into chronic infections, which currently affect more than 500 million patients worldwide. It is generally thought that virus-mediated T-cell exhaustion limits function, thus promoting disease. Here we demonstrate natural killer (NK) cells have a negative impact on the development of immunity by using murine lymphocytic choriomeningitis virus. NK cell-deficient (Nfil3 −/− , E4BP4 ) mice exhibited higher virus-specific response. In...
IL-17-producing CD8+ (Tc17) cells are enriched in active lesions of patients with multiple sclerosis (MS), suggesting a role the pathogenesis autoimmunity. Here we show that amelioration MS by dimethyl fumarate (DMF), mechanistically elusive drug, associates suppression Tc17 cells. DMF treatment results reduced frequency Tc17, contrary to Th17 cells, and decreased ratio regulators RORC-to-TBX21, along shift towards cytotoxic T lymphocyte gene expression signature from patients....
saves mutant mice from infection-induced lethality
Robust cytotoxic CD8 + T-cell response is important for immunity to intracellular pathogens. Here, we show that the transcription factor IFN Regulatory Factor 4 (IRF4) crucial protective bacterium Listeria monocytogenes . IRF4-deficient ( Irf4 −/− ) mice could not clear L. infection and generated decreased numbers of -specific T cells with impaired effector phenotype function. Transfer wild-type into improved bacterial clearance, suggesting an intrinsic defect in mice. Following transfer...
CD8+ T-cell functions are critical for preventing chronic viral infections by eliminating infected cells. For healthy immune responses, beneficial destruction of cells must be balanced against immunopathology resulting from collateral damage to tissues. These processes regulated factors controlling function, which still incompletely understood. Here, we show that the interferon regulatory factor 4 (IRF4) and its cooperating binding partner B-cell-activating transcription (BATF) necessary...
The metabolic principles underlying the differences between follicular and marginal zone B cells (FoB MZB, respectively) are not well understood. Here we show, by studying mice with cell-specific ablation of catalytic subunit glutamate cysteine ligase (Gclc), that glutathione synthesis affects homeostasis differentiation MZB to a larger extent than FoB, while glutathione-dependent redox control contributes dependencies FoB. Specifically, Gclc in FoB induces features wild-type such as...
Cluster of differentiation (CD)8+ T cells are like a double edged sword during chronic viral infections because they not only promote virus elimination but also induce virus-mediated immunopathology. Elevated levels reactive oxygen species (ROS) have been reported infections. However, the role ROS in T-cell-mediated immunopathology remains unclear. Here we used murine lymphocytic choriomeningitis to explore processes and induction We found that infection led elevated producing granulocytes...
Elucidating key factors that regulate immune-mediated pathology in vivo is critical for developing improved strategies to treat autoimmune disease and cancer. NK cells can exhibit regulatory functions against CD8+ T following viral infection. Here we show while low doses of lymphocytic choriomeningitis virus (LCMV-WE) readily induce strong cell responses diabetes mice expressing the LCMV glycoprotein on -islet (RIP-GP mice), hyperglycemia does not occur after infection with higher LCMV....
The Interleukin (IL)-12 family contains several heterodimeric composite cytokines which share subunits among each other. IL-12 consists of the p40 (shared with IL-23) and p35. p35 is shared cytokine IL-35 comprises p35/EBI3 heterodimer (EBI3 IL-27). signals via homo- or heterodimers IL-12Rβ2, gp130 WSX-1, are IL-27 receptor complexes, respectively. was efficiently secreted in complex as but not EBI3 transfected cell lines tested complicates analysis signal transduction. form an inter-chain...
The B cell-activating factor (BAFF) is critical for cell development and humoral immunity in mice humans. While the role of BAFF cells has been widely described, its innate remains unknown. Using receptor (BAFFR)-deficient mice, we characterized BAFFR-related adaptive immune functions following infection with vesicular stomatitis virus (VSV) lymphocytic choriomeningitis (LCMV). We identified a BAFFR signaling generation maintenance CD169(+) macrophage compartment. Consequently, Baffr(-) (/)...
STAT3 is a critical transcription factor activated downstream of cytokine signaling and integral for the function multiple immune cell types. Human mutations in cause primary immunodeficiency resulting impaired control variety infections, including reactivation latent viruses. In this study, we investigate how T‐cell functions contribute to responses viral infection by inducing chronic lymphocytic choriomeningitis virus (LCMV) mice lacking specifically T cells. Although with conditional...
Abstract Pyruvate dehydrogenase (PDH) is the gatekeeper enzyme into tricarboxylic acid (TCA) cycle. Here we show that PARK7/DJ-1, a key familial Parkinson’s disease (PD) gene, pacemaker controlling PDH activity in CD4 regulatory T cells (Tregs). DJ-1 bound to PDH-E1 beta (PDHB), inhibiting phosphorylation of alpha (PDHA), thus promoting and oxidative (OXPHOS). Dj-1 depletion impaired Treg proliferation cellularity maintenance older mice, increasing severity during remission phase...
Although the intestinal tract is a major site of reactive oxygen species (ROS) generation, mechanisms by which antioxidant defense in gut T cells contribute to homeostasis are currently unknown. Here we show, using cell-specific ablation catalytic subunit glutamate cysteine ligase (