A5007907140- Proteoglycans and glycosaminoglycans research
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Cell Adhesion Molecules Research
- T-cell and B-cell Immunology
- Wound Healing and Treatments
- Glycosylation and Glycoproteins Research
- Polysaccharides and Plant Cell Walls
- Fibroblast Growth Factor Research
- Coastal and Marine Management
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- CAR-T cell therapy research
- Immune Response and Inflammation
- NF-κB Signaling Pathways
- Acupuncture Treatment Research Studies
- Peptidase Inhibition and Analysis
- Wnt/β-catenin signaling in development and cancer
- Genetics, Bioinformatics, and Biomedical Research
- Cruise Tourism Development and Management
- Kruppel-like factors research
- PI3K/AKT/mTOR signaling in cancer
- Microtubule and mitosis dynamics
- Plant Surface Properties and Treatments
- Cancer-related gene regulation
- Health, Environment, Cognitive Aging
Health Affairs
2021
University Health Network
2014-2017
Princess Margaret Cancer Centre
2017
Western University
2004-2015
London Health Sciences Centre
2007-2014
Ontario Institute for Cancer Research
2011-2014
University of Toronto
2014
Lawson Health Research Institute
2012
Laboratoire de Biochimie
2006
Djurkliniken Roslagstull
1973
Rhamm (receptor for hyaluronan-mediated motility) is an hyaluronan binding protein with limited expression in normal tissues and high advanced cancers. To understand its physiological functions identify the molecular mechanisms underlying these functions, we created mice a genetic deletion of Rhamm. We show that Rhamm−/− fibroblasts fail to resurface scratch wounds >3 mm or invade hyaluronan-supplemented collagen gels culture. requirement localization CD44 cell surface, formation...
Hyaluronan is activated by fragmentation and controls inflammation fibroplasia during wound repair diseases (eg, cancer). Hyaluronan-binding peptides were identified that modify fibrogenesis skin repair. Peptides selected from 7- to 15mer phage display libraries panning with hyaluronan-Sepharose beads assayed for their ability block fibroblast migration in response hyaluronan oligosaccharides (10 kDa). A peptide (P15-1), homology receptor mediated motility (RHAMM) binding sequences, was the...
CD8+ T-cell functions are critical for preventing chronic viral infections by eliminating infected cells. For healthy immune responses, beneficial destruction of cells must be balanced against immunopathology resulting from collateral damage to tissues. These processes regulated factors controlling function, which still incompletely understood. Here, we show that the interferon regulatory factor 4 (IRF4) and its cooperating binding partner B-cell-activating transcription (BATF) necessary...
Significance More than 1 million people worldwide suffer from the debilitating neurological disorder multiple sclerosis (MS). The initiation of MS is associated with sustained inflammation and an autoimmune T-cell response targeting central nervous system. activities Th1 Th17 effector T cells, which are main pathogenic drivers MS, balanced by regulatory dampen mitigate disease. Our study describes important role for surface receptor Toso in balancing these subsets controlling inflammation....
Abstract T-cell proliferation is regulated by ubiquitination but the underlying molecular mechanism remains obscure. Here we report that Lys-48-linked of transcription factor KLF4 mediated E3 ligase Mule promotes entry into S phase. elevated in T cells upon TCR engagement, and deficiency blocks because accumulates drives upregulation its transcriptional targets E2F2 cyclin-dependent kinase inhibitors p21 p27. T-cell-specific knockout (TMKO) mice develop exacerbated experimental autoimmune...
The interaction of hyaluronan (HA) with mesenchymal progenitor cells impacts trafficking and fate after tissue colonization during wound repair these events contribute to diseases such as cancer. How this occurs is poorly understood. Using 10T½ a model fluorescent (F-HA) or gold-labeled HA (G-HA) polymers, we studied the role two receptors, RHAMM CD44, in binding uptake non-adherent adherent (10T1/2) mimic aspects cell colonization. We show that labeled binding/uptake was high but dropped...
Abstract The decision between T cell activation and tolerance is governed by the spatial temporal integration of diverse molecular signals events occurring downstream TCR costimulatory or coinhibitory receptor engagement. PI3K–protein kinase B (PKB; also known as Akt) signaling pathway a central axis in mediating proximal CD28 engagement cells. Perturbation PI3K–PKB pathway, loss negative regulators activation, such E3 ubiquitin ligase Cbl-b, have been reported to lead increased...
The pharmacodynamics and elimination kinetics of escalating doses (1.5-12 mg/kg) hyaluronan (HA) infusions were studied in healthy human volunteers. Metabolic breakdown serum HA associated adverse events monitored throughout the study. HA-binding capacities circulating CD4+ CD8+ T lymphocytes, CD19+ Blymphocytes CD14+ peripheral blood monocytes (PBMC) also quantified. Breakdown infused into small fragments (<37 kDa) not detected related to infrequent non-serious nature. Binding FITC-HA was...
Abstract The microenvironment plays a key role in cancer progression and metabolism of the extracellular matrix component hyaluronan (HA), glycosaminoglycan, is associated with breast tumor progression. High molecular weight HA degraded by hyaluronidases free radicals to fragments heterogeneous size, which accumulate peritumor stroma activate signaling pathways both stromal cells. receptor RHAMM multifunctional protein that found on cell surface, inside nucleus mitotic spindles mesenchymal...
allergic type of drug fever.It is quite possible that this reaction to the could explain why temperature in cases treated by Drs.McHardy and Schonell with higher dose became normal later than those lower.-Iam, etc.,