A5089040527- Wnt/β-catenin signaling in development and cancer
- T-cell and B-cell Immunology
- PI3K/AKT/mTOR signaling in cancer
- NF-κB Signaling Pathways
- Toxin Mechanisms and Immunotoxins
- Immune Cell Function and Interaction
Princess Margaret Cancer Centre
2017
Ontario Institute for Cancer Research
2007
University of Toronto
2007
Abstract An effective immune response requires the expansion and survival of a large number activated T cells. This study compared role protein kinase C (PKC)θ associated signaling molecules in primary CD4+ vs CD8+ murine We demonstrate that absence PKCθ resulted moderate defect cells striking lymphocytes. lacking c-Rel, but not NF-κB1/p50, member NF-κB family transcription factors displayed similar impairment cell as PKCθ−/− implicates c-Rel key target PKCθ-mediated signals In addition,...
Abstract The decision between T cell activation and tolerance is governed by the spatial temporal integration of diverse molecular signals events occurring downstream TCR costimulatory or coinhibitory receptor engagement. PI3K–protein kinase B (PKB; also known as Akt) signaling pathway a central axis in mediating proximal CD28 engagement cells. Perturbation PI3K–PKB pathway, loss negative regulators activation, such E3 ubiquitin ligase Cbl-b, have been reported to lead increased...