A5003806625- Atherosclerosis and Cardiovascular Diseases
- Immune cells in cancer
- EEG and Brain-Computer Interfaces
- Chemokine receptors and signaling
- Optical Imaging and Spectroscopy Techniques
- Non-Invasive Vital Sign Monitoring
- Cancer, Hypoxia, and Metabolism
- Wnt/β-catenin signaling in development and cancer
- Sphingolipid Metabolism and Signaling
- PI3K/AKT/mTOR signaling in cancer
- Pharmacological Effects of Natural Compounds
- High Altitude and Hypoxia
- Immune Response and Inflammation
- Cell Adhesion Molecules Research
- Gaze Tracking and Assistive Technology
- Toxin Mechanisms and Immunotoxins
- Single-cell and spatial transcriptomics
- Plant-derived Lignans Synthesis and Bioactivity
- Neuroscience and Neural Engineering
University Health Network
2016-2021
University of Toronto
2008-2021
Toronto General Hospital
2021
Princess Margaret Cancer Centre
2017-2020
Holland Bloorview Kids Rehabilitation Hospital
2009
Corporeal machine interfaces (CMIs) are one of a few available options for restoring communication and environmental control to those with severe motor impairments. Cognitive processes detectable solely functional imaging technologies such as near-infrared spectroscopy (NIRS) can potentially provide requiring less user training than conventional electroencephalography-based CMIs. We hypothesized that visually-cued emotional induction tasks elicit forehead hemodynamic activity be harnessed...
Dendritic cells are sentinels of the immune system and represent a key cell in activation adaptive response. Hypoxia-inducible factor 1 alpha (HIF-1α)–a crucial oxygen sensor stabilized during hypoxic conditions–has been shown to have both activating inhibitory effects context- cell-dependent manner. Previous studies demonstrated that some types, HIF-1α serves pro-inflammatory role. Genetic deletion macrophages has reported reduce their function. In contrast, loss enhanced activity dendritic...
Rationale: Bone marrow transplantation (BMT) is used frequently to study the role of hematopoietic cells in atherosclerosis, but aortic arch lesions are smaller mice after BMT. Objective: To identify earliest stage atherosclerosis inhibited by BMT and elucidate potential mechanisms. Methods Results: Ldlr −/− underwent total body γ-irradiation, bone reconstitution, 6-week recovery. Atherosclerosis was studied ascending compared with without In mice, neutral lipid myeloid cell topography were...
Abstract The decision between T cell activation and tolerance is governed by the spatial temporal integration of diverse molecular signals events occurring downstream TCR costimulatory or coinhibitory receptor engagement. PI3K–protein kinase B (PKB; also known as Akt) signaling pathway a central axis in mediating proximal CD28 engagement cells. Perturbation PI3K–PKB pathway, loss negative regulators activation, such E3 ubiquitin ligase Cbl-b, have been reported to lead increased...