A5102716191- Retinal Diseases and Treatments
- Angiogenesis and VEGF in Cancer
- Glaucoma and retinal disorders
- Complement system in diseases
- Adenosine and Purinergic Signaling
- Retinal Development and Disorders
- Corneal Surgery and Treatments
- Antibiotics Pharmacokinetics and Efficacy
- Advanced Fluorescence Microscopy Techniques
- Retinal Imaging and Analysis
- Cannabis and Cannabinoid Research
- Mass Spectrometry Techniques and Applications
- CAR-T cell therapy research
- Blood Coagulation and Thrombosis Mechanisms
- Connective Tissue Growth Factor Research
- Whipple's Disease and Interleukins
- Immune Cell Function and Interaction
- Neonatal Health and Biochemistry
- Retinal and Macular Surgery
- Glycosylation and Glycoproteins Research
- Nicotinic Acetylcholine Receptors Study
- Ubiquitin and proteasome pathways
Novartis (United States)
2015-2021
Foundation for Biomedical Research
2015
The alternative pathway (AP) of the complement system is a key contributor to pathogenesis several human diseases including age-related macular degeneration, paroxysmal nocturnal hemoglobinuria (PNH), atypical hemolytic uremic syndrome (aHUS), and various glomerular diseases. serine protease factor B (FB) node in AP integral formation C3 C5 convertase. Despite prominent role FB AP, selective orally bioavailable inhibitors, beyond our own efforts, have not been reported previously. Herein we...
Background NIZ985 is a recombinant heterodimer of physiologically active interleukin (IL-)15 and IL-15 receptor alpha. In preclinical models, promotes cytotoxic lymphocyte proliferation, killing function, organ/tumor infiltration, with resultant anticancer effects. this first-in-human study, we assessed the safety, pharmacokinetics, immune effects in patients metastatic or unresectable solid tumors. Methods Single agent dose escalation data are reported from phase I escalation/expansion...
Mục tiêu của nghiên cứu này là đánh giá đặc tính lý hóa sinh tinh trùng cá tầm Nga (Acipenser gueldenstaedtii) nuôi tại tỉnh Lâm Đồng. Tinh được thu thập từ đàn đực thành thục dục với khối lượng trung bình (9,86±1,58 kg). Các xác định bằng các phương pháp phù hợp. Kết quả cho thấy: có thể tích (63,33±25,74 ml), độ quánh (60,56±3,91%), mật (0,37×109 trùng/ml), nồng thẩm thấu (69,65±5,06 mOsm/kg), Ion Na+ (34,42±2,10 mM), K+ (2,30±0,14 Ca2+ (0,36±0,04 Mg2+ (0,73±0,05 Cl- (13,62±0,53 Na+/Cl-...
Abstract Protein drugs that neutralize vascular endothelial growth factor (VEGF), such as aflibercept or ranibizumab, rescue vision in patients with retinal diseases. Nonetheless, optimal visual outcomes require intraocular injections frequently every month. Here we report a method to extend the intravitreal half-life of protein an alternative either encapsulation chemical modifications polymers. We combine 97-amino-acid peptide human origin binds hyaluronan, major macromolecular component...
A noninvasive topical ocular therapy for the treatment of neovascular or "wet" age-related macular degeneration would provide a patient administered alternative to current standard care, which requires physician intravitreal injections. This manuscript describes novel strategy use in vivo models choroidal neovascularization (CNV) as primary means developing SAR related efficacy from administration. Ultimately, this effort led discovery acrizanib (LHA510), small-molecule VEGFR-2 inhibitor...
The benefit of intravitreal anti-VEGF therapy in treating wet age-related macular degeneration (AMD) is well established. Identification VEGFR-2 inhibitors with optimal ADME properties for an ocular indication provides opportunities dosing routes beyond injection. We employed a high-throughput vivo screening strategy rodent models choroidal neovascularization and iterative compound design to identify potential AMD patients. These compounds demonstrate preferential tissue distribution...
Matrix-assisted laser desorption/ionization imaging mass spectrometry (MALDI IMS) is becoming an important technology to determine the distribution of drugs and their metabolites in tissue preclinical species after dosing. Interest IMS growing ophthalmology field, but little work this point has been done investigate ocular drug transit using technology. Information on where how a distributing through eye understanding efficacy whether it reaching desired target tissue. For study, brimonidine...
Complement factor D (FD), a highly specific S1 serine protease, plays central role in the amplification of alternative complement pathway (AP) innate immune system. Dysregulation AP activity predisposes individuals to diverse disorders such as age-related macular degeneration, atypical hemolytic uremic syndrome, membranoproliferative glomerulonephritis type II, and paroxysmal nocturnal hemoglobinuria. Previously, we have reported screening efforts identification reversible benzylamine-based...
Glaucoma is a leading cause of vision loss and blindness, with increased intraocular pressure (IOP) prominent risk factor. IOP can be efficaciously reduced by administration topical agents. However, the repertoire approved IOP-lowering drug classes limited, effective new alternatives are needed. Agonism cannabinoid receptors CB1/2 significantly reduces clinically experimentally. development agonists has been complicated need to avoid cardiovascular psychotropic side effects. 1 potent agonist...