A5000737469- Non-Invasive Vital Sign Monitoring
- Hemodynamic Monitoring and Therapy
- Mobile Health and mHealth Applications
- COVID-19 diagnosis using AI
- COVID-19 Clinical Research Studies
- Heart Rate Variability and Autonomic Control
- Total Knee Arthroplasty Outcomes
- Orthopaedic implants and arthroplasty
- Cell Image Analysis Techniques
- Optical Imaging and Spectroscopy Techniques
- Retinal Diseases and Treatments
- Phytochemistry and Bioactive Compounds
- Polyamine Metabolism and Applications
- Nitric Oxide and Endothelin Effects
- Advanced Technologies in Various Fields
- Phytochemical Studies and Bioactivities
- Pulmonary Hypertension Research and Treatments
- Extracellular vesicles in disease
- Literature, Magical Realism, García Márquez
- Streptococcal Infections and Treatments
- Erythrocyte Function and Pathophysiology
- Corneal Surgery and Treatments
- SARS-CoV-2 detection and testing
- Complement system in diseases
- Blood Coagulation and Thrombosis Mechanisms
Beijing Tian Tan Hospital
2024
First Teaching Hospital of Tianjin University of Traditional Chinese Medicine
2021-2023
City University of Hong Kong
2020-2023
Hong Kong Science and Technology Parks Corporation
2023
Hengshui University
2020
Tianjin University of Traditional Chinese Medicine
2020
Novartis (United States)
2018-2019
First Affiliated Hospital of Shihezi University Medical College
2017
Novartis (Switzerland)
2015
Englerin A is a structurally unique natural product reported to selectively inhibit growth of renal cell carcinoma lines. large scale phenotypic profiling experiment (CLiP) englerin on ¬over 500 well characterized cancer lines showed that inhibits subset tumor from many lineages, not just carcinomas. Expression the TRPC4 cation channel was line feature best correlated with sensitivity A, suggesting hypothesis efficacy target for A. Genetic experiments demonstrate expression both necessary...
Because of the rapid and serious nature acute cardiovascular disease (CVD) especially ST segment elevation myocardial infarction (STEMI), a leading cause death worldwide, prompt diagnosis treatment is crucial importance to reduce both mortality morbidity. During pandemic such as coronavirus disease-2019 (COVID-19), it critical balance emergencies with infectious risk. In this work, we recommend using wearable device based mobile health (mHealth) an early screening real-time monitoring tool...
Aim: Photoplethysmography (PPG) has gained widespread popularity as a non-invasive method for potential cuff-less blood pressure (BP) measurement in smart devices. However, the accuracy of PPG-based devices is often hindered by motion artifacts, site variability, and inconsistent contact force (CF). This study aims to investigate influence CF variations on PPG signals. Methods: To address these challenges, we present novel approach involving multi-channel array integrated with regulation...
Complement factor D (FD), a highly specific S1 serine protease, plays central role in the amplification of alternative complement pathway (AP) innate immune system. Dysregulation AP activity predisposes individuals to diverse disorders such as age-related macular degeneration, atypical hemolytic uremic syndrome, membranoproliferative glomerulonephritis type II, and paroxysmal nocturnal hemoglobinuria. Previously, we have reported screening efforts identification reversible benzylamine-based...
OBJECTIVE To explore the mechanism of Piezo1 protein in mediating osteogenic differentiation human periodontal ligament stem cells (hPDLSCs) via Notch signaling pathway. METHODS In this study, young permanent teeth extracted from impacted 8-14-year- old children January 1, 2016 to 2018 Department Orthodontic, Beijing Children's Hospital were selected as cell sources. hPDLSCs by enzymatic digestion. Immunohistochemical staining was used detect expression keratin and vimentin, flow cytometry...
Soluble guanylate cyclase (sGC), the endogenous receptor for nitric oxide (NO), has been implicated in several diseases associated with oxidative stress. In a pathological environment, heme group of sGC can be oxidized becoming unresponsive to NO leading loss ability catalyze production cGMP. Recently dysfunctional sGC/NO/cGMP pathway contributing elevated intraocular pressure glaucoma. Herein we describe discovery molecules specifically designed topical ocular administration, which activate...
Different from the traditional methods of assessing cardiac activities through heart rhythm statistics or P-QRS-T complexes separately, this study demonstrates their interactive effects on power density spectrum (PDS) ECG signal with applications for diagnosis ST-segment elevation myocardial infarction (STEMI) diseases. Firstly, a mathematical model PDS random pacing pulse train (PPT) mimicking S-A node firings was derived. Secondly, an experimental analysis performed clinical signals 49...
The measurement and monitoring of continuous arterial blood pressure (BP) have undergone significant evolution over the past 170 years, transitioning from ancient invasive approaches, like kymograph, to modern non-invasive unobtrusive technologies such as tonoarteriography (TAG). This progressive shift has revolutionized way we track BP, providing safer, more accurate, convenient methods for BP. paper aims provide some historical perspectives on development BP technology, highlight key...
This work introduces a novel framework for holistic comparative analysis of cortical regions in mouse and human brains at single-neuron resolution, with primary focus on the morphological molecular characteristics neurons. To do so, we generated one largest dendritic reconstruction datasets neurons to date, comprising 2,363 16,011 from frontal, parietal, temporal lobes, followed by establishing rigorous procedure identify anatomically functionally corresponding brain minimal variability...
<title>Abstract</title> This work introduces a novel framework for holistic comparative analysis of cortical regions in mouse and human brains at single-neuron resolution, with primary focus on the morphological molecular characteristics neurons. To do so, we generated one largest dendritic reconstruction datasets neurons to date, comprising 2,363 16,011 from frontal, parietal, temporal lobes, followed by establishing rigorous procedure identify anatomically functionally corresponding brain...
Abstract Mesenchymal stem cells (MSCs) belong to the family of pluripotent cells, which have an obvious multi-directional differentiation potential and can regulate immune response organism by influencing cell subsets, thus they excellent prospects for application in inflammation, diseases, organ transplantation. Numerous studies shown that MSCs are a promising strategy treatment cardiovascular disease modulating subsets coordinating local systemic innate adaptive responses, thereby enabling...
Proximal tibial aspect ratio (PTAR) is closely related to age, disease status and cutting parameters with considerable inter-individual variation independent of gender race, nevertheless the components from different manufacturers remains relatively constant smallest largest size. As a result, component mismatching an unavoidable dilemma during tibia preparation in total knee arthroplasty (TKA). Various prosthesis systems all can achieve more than 80% coverage on proximal tibia, whereas...
During the past three years, tremendous efforts have been made to tackle Coronavirus Disease 2019 (COVID-19) crisis, including centralized quarantine, compulsory testing, and sweeping lockdowns. The measures taken effect, but caused a huge burden on healthcare systems significant disruption global economies an unprecedented scale. Recently, some countries regions observed signs of pandemic resurgence. To better handle resurgence in post-COVID era future pandemics, immediate revolution...