A5050500319- Oxidative Organic Chemistry Reactions
- Alkaloids: synthesis and pharmacology
- Vanadium and Halogenation Chemistry
- Chemical synthesis and alkaloids
- Advanced Synthetic Organic Chemistry
- Complement system in diseases
- Retinal Diseases and Treatments
- Carbohydrate Chemistry and Synthesis
- Chemical Synthesis and Reactions
- Neonatal Health and Biochemistry
- Asymmetric Synthesis and Catalysis
- Catalytic Cross-Coupling Reactions
- Natural product bioactivities and synthesis
- Metal-Catalyzed Oxygenation Mechanisms
- Adenosine and Purinergic Signaling
- Nanomaterials for catalytic reactions
- Catalytic C–H Functionalization Methods
The University of Texas at Austin
2018-2021
Novartis (United States)
2019-2020
Corteva (United States)
2019
The alternative pathway (AP) of the complement system is a key contributor to pathogenesis several human diseases including age-related macular degeneration, paroxysmal nocturnal hemoglobinuria (PNH), atypical hemolytic uremic syndrome (aHUS), and various glomerular diseases. serine protease factor B (FB) node in AP integral formation C3 C5 convertase. Despite prominent role FB AP, selective orally bioavailable inhibitors, beyond our own efforts, have not been reported previously. Herein we...
A general protocol is described for inducing enantioselective halolactonizations of unsaturated carboxylic acids using novel bifunctional organic catalysts derived from a chiral binaphthalene scaffold. Bromo- and iodolactonization reactions diversely substituted, proceed with high degrees enantioselectivity, regioselectivity, diastereoselectivity. Notably, these BINOL-derived are the first to induce bromo- iodolactonizations 5-alkyl-4(Z)-olefinic via 5-exo mode cyclizations give lactones in...
The potential safety hazards associated with the Mizoroki–Heck cross-coupling of bromobenzenes styrenes were evaluated. heat output from reaction in various solvents was comparable a variety solvents; however, rate significantly faster presence water. Thermal stability evaluation postreaction mixtures DMSO and 3:1 DMSO/water by differential scanning calorimetry indicated that onset temperatures thermal decomposition lower than neat DMSO. Evaluation substrate scope revealed substitution...
The shortest synthesis to date of (±)-alstoscholarisine E was accomplished in seven linear steps from commercially available reagents and 15.2% overall yield. approach features a tandem vinylogous Mannich reaction hetero-Diels–Alder access the core. A novel tactic induce diastereoselective reduction cyclic vinyl ether discovered, mild procedure form bridged aminal ring by partial lactam via iridium-catalyzed hydrosilylation developed.
The BINOL-amidine organic catalyst 1 was previously shown to promote highly efficient enantioselective halolactonization reactions of olefinic acids. As part these studies, it discovered that the enantioenriched iodolactones could be easily converted into cis-1,2-disubstituted epoxides. This halolactonization-epoxidation sequence applied synthesis (+)-disparlure, which resulted in shortest catalytic date, requiring only five steps and proceeding 33% yield.
We previously reported a bifunctional organic catalyst that promotes highly efficient enantioselective halolactonizations of broad array olefinic acids. As part work, we demonstrated the desymmetrization prochiral substrate through catalytic halolactonization, and report herein application one such process to syntheses F-ring subunit synthons (+)-kibdelone C.