A5100662110- Cancer-related molecular mechanisms research
- Endometrial and Cervical Cancer Treatments
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Genetic Associations and Epidemiology
- Ovarian cancer diagnosis and treatment
- Liver physiology and pathology
- Cancer-related gene regulation
- FOXO transcription factor regulation
- Mitochondrial Function and Pathology
- Monoclonal and Polyclonal Antibodies Research
- Metabolism and Genetic Disorders
- Histone Deacetylase Inhibitors Research
- Reproductive System and Pregnancy
- RNA Research and Splicing
- Estrogen and related hormone effects
- Circular RNAs in diseases
- Nutrition, Genetics, and Disease
- Gynecological conditions and treatments
- Birth, Development, and Health
- Hemoglobinopathies and Related Disorders
- Genomics and Chromatin Dynamics
- Renal Diseases and Glomerulopathies
- Diet and metabolism studies
- Gastric Cancer Management and Outcomes
Chinese Academy of Sciences
2012-2025
Sun Yat-sen University
2017-2025
Center for Excellence in Molecular Cell Science
2010-2025
Peking University People's Hospital
2019-2024
Peking University
2019-2024
Cornell University
2016-2024
The First Affiliated Hospital, Sun Yat-sen University
2021-2024
Army Medical University
2007-2024
State Key Laboratory of Oncogene and Related Genes
2023-2024
Xinqiao Hospital
2015-2024
Purpose: The long, noncoding RNA (lncRNA) PVT1 is an important epigenetic regulator with a critical role in human tumors. Here, we aimed to investigate the clinical application and potential molecular mechanisms of gastric cancer tumorigenesis progression.Experimental Design: expression level was determined by RT-qPCR analysis 190 pairs tissues adjacent normal mucosa (ANT). biologic functions were assessed vitro vivo functional experiments. protein pull-down assays LS/MS mass spectrometry...
Substantial progress has been made in identification of type 2 diabetes (T2D) risk loci the past few years, but our understanding genetic basis T2D ethnically diverse populations remains limited. We performed a genome-wide association study and replication Chinese Hans comprising 8,569 case subjects 8,923 control total, from which 10 single nucleotide polymorphisms were selected for further follow-up de novo sample 3,410 3,412 an silico 6,952 11,865 subjects. Besides confirming seven...
The accumulation of mitochondrial DNA (mtDNA) mutations, and the reduction mtDNA copy number, both disrupt energetics, may contribute to aging age-associated phenotypes. However, there are few genetic epidemiological studies on spectra blood heteroplasmies, distribution numbers in different age groups their impact age-related In this work, we used whole-genome sequencing data isolated peripheral mononuclear cells (PBMCs) from UK10K project investigate parallel heteroplasmy number 1511 women,...
Hyperhomocysteinemia (HHcy) has been shown to promote vascular inflammation and atherosclerosis, but the underlying mechanisms remain largely unknown. The NLRP3 inflammasome identified as cellular machinery responsible for activation of inflammatory processes. In this study, we hypothesized that inflammasomes contributes HHcy-induced atherosclerosis. ApoE-/- mice were fed regular chow, high-fat (HF) diet, or HF plus high methionine diet induce HHcy. To assess role in HHcy-aggravated shRNA...
Abstract Endometrial cancers are complex ecosystems composed of cells with distinct phenotypes, genotypes, and epigenetic states. Current models do not adequately reflect oncogenic origin pathological progression in patients. Here we use single-cell RNA sequencing to profile from normal endometrium, atypical endometrial hyperplasia, endometrioid cancer (EEC), which altogether represent the step-by-step development cancer. We find that EEC originates epithelial but stromal cells, unciliated...
Huntington's disease (HD) predominantly affects the brain, causing a mixed movement disorder, cognitive decline and behavioural abnormalities. It also causes peripheral phenotype involving skeletal muscle. Mitochondrial dysfunction has been reported in tissues of HD models, including muscle, lymphoblast fibroblast cultures from patients with HD. Mutant huntingtin protein (mutHTT) expression can impair mitochondrial quality control accelerate ageing. Here, we obtained fresh human post-mitotic...
Plasma lipid levels are important risk factors for cardiovascular disease and influenced by genetic environmental factors. Recent genome wide association studies (GWAS) have identified several lipid-associated loci, but these loci been primarily in European populations. In order to identify markers a Chinese population analyze the heterogeneity between Europeans Asians, especially Chinese, we performed meta-analysis of two on four common traits including total cholesterol (TC), triglycerides...
Increasing clinical and biochemical evidence implicate mitochondrial dysfunction in the pathophysiology of Autism Spectrum Disorder (ASD), but little is known about biological basis for this connection. A possible cause ASD genetic variation DNA (mtDNA) sequence, which has yet to be thoroughly investigated large genomic studies ASD. Here we evaluated mtDNA variation, including mixture different molecules same individual (i.e., heteroplasmy), using whole-exome sequencing data from...
// Yiqin Wang 1 , Xianrong Zhou Midie Xu 2, 3, 4, 5 Weiwei Weng Qiongyan Zhang Yusi Yang Ping Wei 6 Xiang Du Department of Pathology, Obstetrics and Gynecology Hospital Fudan University, Shanghai 200044, China 2 University Cancer Center, 200032, 3 Medical College, 4 Institute Biomedical Sciences, Institute, Correspondence to: Wei, e-mail: ripplepz@gmail.com Du, dx2008cn@163.com Keywords: OTUB1, FOXM1, ovarian carcinoma, ubiquitination, deubiquitination Received: August 12, 2015 Accepted:...
The present study aimed to investigate the effect of metformin on diabetes-accelerated atherosclerosis and whether Nod-like receptor protein 3 (NLRP3) inflammasome is a target for metformin. ApoE−/− male mice were divided randomly into control, streptozocin-induced diabetes mellitus groups. Metabolic parameters, atherosclerotic lesion, activation NLRP3 inflammasomes related signaling pathways detected. THP-1-differentiated macrophages used in vitro experiments. Compared with control mice,...
<h3>Importance</h3> Anti–programmed cell death 1 (anti–PD-1) immunotherapy features a durable response and improved survival in small subset of patients with recurrent or metastatic nasopharyngeal carcinoma (RM-NPC). The association between plasma Epstein-Barr virus (EBV) DNA titer dynamics efficacy anti–PD-1 monotherapy has been reported, while its value predicting long-term outcomes monitoring disease progression is unclear for RM-NPC who are receiving monotherapy. <h3>Objective</h3> To...
Mitochondria are essential for brain development. While previous studies linked dysfunctional mitochondria with autism spectrum disorder (ASD), the role of mitochondrial genome (mtDNA) in ASD risk is largely unexplored. This study investigates association mtDNA heteroplasmies (co-existence mutated and unmutated mtDNA) content ASD, as well its inter-generational transmission sex differences among two independent samples: a family-based (n = 1,938 families parents, probands sibling controls)...
Significance Decline of mitochondrial function may underlie the pathogenesis many age-related diseases, such as Huntington’s disease (HD). Mitochondrial oxidative phosphorylation (OXPHOS) system is encoded partially by genome (mtDNA). By investigating mtDNA in lymphoblast and blood samples HD patients, we found that expansion OXPHOS-impairing heteroplasmies (coexistence mutated wild-type mtDNA) a molecular feature associated with functional, motor, cognitive aspects progression, suggesting...
Abstract Jumonji C‐terminal (JmjC) domain‐containing proteins are protein hydroxylases and histone demethylases that control gene expression. 6 (Jmjd6) is indispensable for embryonic development has both arginine demethylase lysyl‐hydroxylase activities. The undergoes post‐translational homo‐oligomerization, but the underlying mechanism remains unknown. In this study, we examined enzymatic activity of Jmjd6 uncovered its homo‐oligomerization. An in vitro assay monitored by matrix‐assisted...
Abstract Protein drugs that neutralize vascular endothelial growth factor (VEGF), such as aflibercept or ranibizumab, rescue vision in patients with retinal diseases. Nonetheless, optimal visual outcomes require intraocular injections frequently every month. Here we report a method to extend the intravitreal half-life of protein an alternative either encapsulation chemical modifications polymers. We combine 97-amino-acid peptide human origin binds hyaluronan, major macromolecular component...