A5090869595- Multiple Myeloma Research and Treatments
- Ferroptosis and cancer prognosis
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cancer Immunotherapy and Biomarkers
- Ovarian cancer diagnosis and treatment
- Metallurgical Processes and Thermodynamics
- Extraction and Separation Processes
- Cancer Mechanisms and Therapy
- Signaling Pathways in Disease
- Peripheral Neuropathies and Disorders
- Systemic Lupus Erythematosus Research
- Inflammasome and immune disorders
- Molten salt chemistry and electrochemical processes
- Atherosclerosis and Cardiovascular Diseases
- Circadian rhythm and melatonin
- Cancer-related molecular mechanisms research
- Monoclonal and Polyclonal Antibodies Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Blood Pressure and Hypertension Studies
- Apelin-related biomedical research
- Cancer-related gene regulation
- Cancer, Lipids, and Metabolism
Shanghai Changzheng Hospital
2022-2025
Second Military Medical University
2022-2025
University of Science and Technology Beijing
2011
Abstract Background Cholangiocarcinoma represents a malignant neoplasm originating from the hepatobiliary tree, with subset of tumors developing inside liver. Intrahepatic cholangiocarcinomas (ICC) commonly exhibit an asymptomatic presentation, rendering both diagnosis and treatment challenging. Cuproptosis, emerging regulated cell death pathway induced by copper ions, has garnered attention recently. As cancer cells show altered metabolism comparatively higher needs, cuproptosis may play...
Background: Tubulin alpha 1b (TUBA1B) is a key microtubule protein essential for maintaining cellular structure and function. This contributes significantly to cytoskeletal formation implicated in various diseases. Despite its fundamental roles, TUBA1B’s impact on tumor prognosis the immune microenvironment across cancer types remains inadequately understood. Methods To elucidate role response, we conducted comprehensive analysis, integrating data from established databases such as The...
This study aimed to investigate the relationship between autoantibodies, specifically Antinuclear Antibody (ANA) and anti-Sjögren's-syndrome-related antigen A (SSA), progression-free survival (PFS) in multiple myeloma (MM) patients. retrospective cohort was conducted on 304 MM patients diagnosed 2010 2020 at Shanghai Changzheng Hospital, with follow-up until October 2023. Patients were stratified based ANA SSA positivity. Clinical data analyzed using Kaplan-Meier curves Cox regression...
Background Aryl hydrocarbon receptor nuclear translocator-like 2 (ARNTL2) belongs to the b HLH- PAS domain transcription factor family and is one of key clock genes that control circadian rhythm. ARNTL2 plays an important role in human biological functions. However, its various tumors, especially tumor immune microenvironment (TIME) immunotherapy, remains unclear. Methods We integrated data from cancer patients multiple databases, including Cancer Genome Atlas, Cell Lineage Encyclopedia,...
Background: Adaptor-related protein complex 3, sigma one subunit (AP3S1) is of the encoding subunits adaptor AP-3. However, its role in various tumor types and relationship with immune microenvironment (TIME) remains unclear. Methods: AP3S1 expression was analyzed using datasets from The Cancer Genome Atlas, Genotype-Tissue Expression, UALCAN, HPA databases. Then, we performed a systematic analysis genetic alterations, clinical features, prognostic value pan-cancer. Gene set enrichment...
Existing biomarkers for ovarian cancer lack sensitivity and specificity. We compared the diagnostic efficacy of nonlinear machine learning linear statistical models diagnosing using a combination conventional laboratory indicators. divided 901 retrospective samples into an group control group, comprising non-ovarian malignant gynecological tumor (NOMGT), benign disease (BGD), healthy subgroups. Cases were randomly assigned to training internal validation sets. Two (logistic regression (LR)...
Cuproptosis is a novel form of programmed cell death that disrupts the tricarboxylic acid (TCA) cycle and mitochondrial function. The mechanism cuproptosis quite different from common forms such as apoptosis, pyroptosis, necroptosis, ferroptosis. However, potential connection between tumor immunity, especially in lung adenocarcinoma (LUAD), poorly understood.We used machine learning algorithms to develop cuproptosis-related scoring system. immunological features system were investigated by...
Background: Multiple myeloma (MM) is a hematological malignancy in which plasma cells proliferate abnormally. 5-methylcytosine (m 5 C) methylation modification the primary epigenetic and involved regulating occurrence, development, invasion, metastasis of various tumors; however, its immunological functions have not been systematically described MM. Thus, this study aimed to clarify significance m C modifications how immune microenvironment linked Method: A total 483 samples (60 healthy...