A5100332206- Autophagy in Disease and Therapy
- Sphingolipid Metabolism and Signaling
- Wound Healing and Treatments
- Synthesis and biological activity
- Advanced Drug Delivery Systems
- RNA Interference and Gene Delivery
- Lung Cancer Diagnosis and Treatment
- Multiple and Secondary Primary Cancers
- Advanced biosensing and bioanalysis techniques
- Natural Compounds in Disease Treatment
- Biological and pharmacological studies of plants
- Calcium signaling and nucleotide metabolism
- Wireless Body Area Networks
- Synthesis of Organic Compounds
- Endoplasmic Reticulum Stress and Disease
- Advancements in Transdermal Drug Delivery
- Wireless Communication Networks Research
- Ferroptosis and cancer prognosis
- Inflammasome and immune disorders
- Sirtuins and Resveratrol in Medicine
- Bee Products Chemical Analysis
- Esophageal Cancer Research and Treatment
- Nerve injury and regeneration
- Liver Disease Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
Sichuan University
2025
State Key Laboratory of Biotherapy
2025
Peking University First Hospital
2025
Peking University
2025
Chengdu University of Traditional Chinese Medicine
2024
Fudan University
2020-2024
Shanghai University of Traditional Chinese Medicine
2021-2023
Affiliated Hospital of Nantong University
2023
Nantong University
2023
China Pharmaceutical University
2023
Targeted delivery and precise release of toxins is a prospective strategy for the treatment triple-negative breast cancer (TNBC), yet flexibility to incorporate both properties simultaneously remains tremendously challenging in X-drug conjugate fields. As critical components conjugates, linkers could flourish achieving optimal functionalities. Here, we pioneered pH-hypersensitive tumor-targeting aptamer AS1411-triptolide (AS-TP) achieve smart toxin targeted therapy against TNBC. The...
Cisplatin-induced ototoxicity is one of the major adverse effects in cisplatin chemotherapy, and hearing protective approaches are unavailable clinical practice. Recent work unveiled a critical role autophagy cell survival various types loss. Since excessive activation can contribute to apoptotic death, whether increases or decreases rate death CDDP still being debated. In this study, we showed that induced auditory HEI-OC1 at early stage. We then used rapamycin, an activator, increase...
ABSTRACT Aims Exploring fibrosis index‐4 (FIB‐4)'s predictive value for HBV‐related hepatocellular carcinoma (HCC) in assessing recurrence following stereotactic body radiation therapy (SBRT) patients with HCC. Methods HCC who underwent SBRT were retrospectively enrolled from March 2012 to 2020. Patients divided into and non‐recurrence groups based on the situation. Baseline data collected all before treatment at 3 6 months after treatment, FIB‐4 was calculated corresponding time points....
Schwann cells (SCs) are the major glial in peripheral nervous system. They unsheathe and myelinate axons play an essential role nerve regeneration. Several studies report that Parkin-mediated mitophagy is associated with various diseases. Melatonin promotes proliferation of central cells. Little known about effect melatonin on repair. In this study, using a rat model injury (PNI) vitro established by RSC96 treated tert-butyl hydroperoxide (TBHP), we found can effectively reduce production...
The random-pattern flap has a significant application in full mouth restoration (reconstructive surgery) and plastic surgery owing to an easy operation with no axial vascular restriction. However, distal necrosis after is still considered the most common complication which makes it Achilles heel clinical of flaps. A Chinese medicinal herb named gastrodin effective active ingredient Gastrodia. Herein, existing study explored potential on survival its underlying mechanism. Our obtained results...
Nonsmall-cell lung cancer (NSCLC) is the main type of cancer, whose morbidity and mortality rank first among malignant tumors. More than 70% NSCLC patients are diagnosed at locally advanced or stage, missing best operation period. Chemotherapy targeted therapy important means for treatment NSCLC, but various side effects seriously affect curative effect life quality patients. Our previous clinical practice has shown that Mufangji Decoction, a classic traditional Chinese medicine, significant...
Cuproptosis is a novel form of programmed cell death that disrupts the tricarboxylic acid (TCA) cycle and mitochondrial function. The mechanism cuproptosis quite different from common forms such as apoptosis, pyroptosis, necroptosis, ferroptosis. However, potential connection between tumor immunity, especially in lung adenocarcinoma (LUAD), poorly understood.We used machine learning algorithms to develop cuproptosis-related scoring system. immunological features system were investigated by...
This study used the Surveillance, Epidemiology, and End Results (SEER) data to investigate clinicopathological characteristics prognoses of patients with esophageal cancer as a second primary from 2000 2015.Esophageal (SEPC) patient information collected SEER database were extracted, evaluated, compared only (OPEC) data. Overall survival (OS) was evaluated by Kaplan-Meier method. Univariate analysis (UVA) multivariate (MVA) Cox proportional hazards regression identified risk factors that...
Abstract Acute myeloid leukemia (AML) is a disease of malignant proliferation abnormally or poorly differentiated cells the hematopoietic system. The clinical treatments non-M3 AML are experiencing lack effective drugs. V8 newly synthesized derivative natural flavonoid wogonin, which belongs to potential anticancer drug, and has shown significant antitumor activity in vitro vivo . In this study, we investigated effects on cell lines primary underlying mechanisms. results showed that...