A5101407749- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Esophageal Cancer Research and Treatment
- Lung Cancer Research Studies
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Gastric Cancer Management and Outcomes
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Medical Imaging and Pathology Studies
- Long-Term Effects of COVID-19
- Sepsis Diagnosis and Treatment
- Metastasis and carcinoma case studies
- Pleural and Pulmonary Diseases
- Cancer Genomics and Diagnostics
- Peptidase Inhibition and Analysis
- Pancreatitis Pathology and Treatment
- Cancer-related molecular mechanisms research
- Occupational and environmental lung diseases
- Brucella: diagnosis, epidemiology, treatment
- COVID-19 and healthcare impacts
- Musculoskeletal pain and rehabilitation
- GDF15 and Related Biomarkers
- Gynecological conditions and treatments
- Heme Oxygenase-1 and Carbon Monoxide
- SARS-CoV-2 detection and testing
Huashan Hospital
2019-2024
Fudan University
2010-2024
Peking University People's Hospital
2024
Peking University
2024
First Affiliated Hospital of Fujian Medical University
2024
Johns Hopkins Medicine
2021-2024
Johns Hopkins University
2021-2024
First Affiliated Hospital of Zhengzhou University
2023
Northwestern University
2023
University of Hong Kong
2016-2020
Purpose: This study used the Surveillance, Epidemiology, and End Results (SEER) data to investigate changes in incidence, treatment, survival of lung cancer from 1973 2015. Patients methods: The clinical epidemiological patients with were obtained SEER database. Joinpoint regression models estimate rate related survival. Results: From 2015, average incidence was 59.0/100,000 personyears. increased initially, reached a peak 1992, then gradually decreased. A higher observed males than females...
BackgroundNirmatrelvir plus ritonavir (Paxlovid) reduced the risk of hospitalization or death by 89% in high-risk, ambulatory adults with COVID-19. We aimed at studying efficacy and safety Paxlovid hospitalized adult patients SARS-Cov-2 (Omicron BA.2.2 variant) infection severe comorbidities.MethodsWe conducted an open-label, multicenter, randomized controlled trial which comorbidities were eligible assigned a 1:1 ratio to receive either 300 mg nirmatrelvir 100 every 12 h for 5 days standard...
Treatment with inhaled carbon monoxide (CO) has been shown to ameliorate intestinal injury induced by lipopolysaccharide (LPS) or ischemia-reperfusion in experimental animals. We hypothesized that CO intraperitoneal administration (i.p) might provide similar protection against gas. In the present study, 1 h after intravenously receiving 5 mg/kg LPS, rats were exposed either room air 2 ml/kg of 250 ppm i.p for 1, 3, and 6 h. Intestinal tissues collected determine levels platelet activator...
ERBB2 exon 20 insertions (20ins) have been identified as oncogenic drivers in lung cancers. Lung cancer patients with 20ins benefit from afatinib. However, response heterogeneity was observed harboring different subtypes. In this study, we interrogated clinical characteristics ERBB2-mutated Chinese and investigated the outcomes of specific to afatinib.In retrospectively collected genomic profiling data 7,520 sequenced using next-generation sequencing a Clinical Laboratory Improvement...
Abstract Previous studies have identified potential risk factors for pulmonary carcinoid tumors and evaluated the effect of various treatments; however, results were not entirely consistent. We conducted a population‐based study to further explore relevant prognostic issues. extracted cases with from Surveillance Epidemiology End Results database. Cox proportional hazard regression was utilized identify significant factors, which helped establish nomogram predicting long‐term survival....
Abstract Purpose This study was performed to investigate the efficacy and safety of combined immunotherapy antiangiogenic therapy for advanced non-small cell lung cancer (NSCLC) in real world. Methods Data on clinicopathological features, adverse events (AEs) were collected retrospectively NSCLC patients who received with therapy. Results A total 85 enrolled. The had a median progression-free survival (PFS) 7.9 months overall (OS) 18.60 months. objective response rate disease control 32.9%...
Background: Pulmonary pleomorphic carcinoma (PPC) is a rare malignancy; unique clinicopathological characteristics and prognosis have not been described. Methods: PPC patient information collected in the Surveillance, Epidemiology, End Results (SEER) database between 2004 2014 were extracted, evaluated, compared with NSCLC data. Overall survival (OS) was evaluated by Kaplan-Meier method. Univariate analysis (UVA) multivariate (MVA) Cox proportional hazards regression identified risk factors...
Objective: To examine the clinical significance of blood lactate (Lac)/serum albumin (Alb) ratio and Lac/Alb × age score for assessing severity prognosis patients with sepsis. Methods: A total 8,029 sepsis, aged >18 years were enrolled between June 2001 to October 2012 from latest version Medical Information Mart Intensive Care III (MIMIC-III v.1.4). The general data obtained hospital records included gender, age, body mass index (BMI), laboratory indices, sequential organ failure assessment...
Background: The aim of this study was to identify risk factors for patients with malignant main stem bronchial tumors (MBTs) and develop a nomogram predicting prognosis in those using data from the Surveillance, Epidemiology, End Results (SEER) database. Method: A process used case screening SEER effect prognostic on survival evaluated Kaplan–Meier method log-rank test, competing model, Cox proportional hazards regression model. established 1-, 3-, 5-year overall (OS) MBTs. Results: total...
Abstract Introduction The SARS-CoV-2 Omicron variant has decreased virulence and pathogenicity, yet the number of infections worldwide is unprecedentedly high, with rather high mortality severe disease rate. Chronic kidney (CKD) patients are particularly vulnerable to have unique clinical outcomes. Methods We retrospectively collected data from 2140 hospitalized infection March 29, 2022, May 17, 2022. Demographic characteristics, ancillary examination results, treatments were described....
Abstract Background Primary pure mucinous adenocarcinoma of the lung (PMA) is a rare subtype. However, correlations between clinicopathological features and genetic phenotypes with survival have not been described comprehensively. Methods Pure patient information collected from Surveillance, Epidemiology, End Results (SEER) database, Department Thoracic Surgery, Zhongshan Hospital, Fudan University (FDZSH), Cancer Genome Atlas (TCGA) were extracted, evaluated, compared other adenocarcinomas...
Objective Health needs of different employee subgroups within an industry can differ. We report the results a workplace cardiopulmonary risk assessment targeting workers and support staff in construction industry. Methods A free worksite-based for 1,903 on infrastructural contracts across Hong Kong was initiated May 2014. Cardiopulmonary screening performed 60-minute blocks approximately 30 workers/block with individualized feedback lifestyle counseling. Risk profiles stratified by...
It is essential to dissect an adequate number of lymph nodes (LNs) ensure staging accuracy during esophagectomy with or without neoadjuvant therapy. We developed a statistical model quantify the probability precise nodal based on previous studies. Esophageal cancer patients who underwent were retrospectively reviewed in Surveillance, Epidemiology, and End Results database. A β-binomial distribution was adopted estimate understaged numbers positive examined LNs. Using 6,252 patients, we...
Brucellosis is a highly contagious zoonotic disease caused by bacteria that belong to the genus Brucella . It major endemic in northern China. We reported rare case of central nervous system (CNS) infection melitensis patient living non-endemic areas. The medical history included chronic headache and trunk numbness. Based on presented clinical symptoms examinations, diagnosis binocular uveo-encephalitis was made local hospital. patient's were unrelieved after being treated with empiric...
This study used the Surveillance, Epidemiology, and End Results (SEER) data to investigate clinicopathological characteristics prognoses of patients with esophageal cancer as a second primary from 2000 2015.Esophageal (SEPC) patient information collected SEER database were extracted, evaluated, compared only (OPEC) data. Overall survival (OS) was evaluated by Kaplan-Meier method. Univariate analysis (UVA) multivariate (MVA) Cox proportional hazards regression identified risk factors that...
Abstract Background Raoultella ornithinolytica is a Gram-negative bacillus that resembles Klebsiella. This bacterium present in many soil and aquatic environments major causative agent of healthcare-associated infections (HAIs) medical staff. Clinically, it has been reported to contribute nosocomial patients include but are not limited gastrointestinal, skin, genitourinary tract infections. These complications most common hospitalized with underlying immunodeficiency, multiple comorbidities,...
<title>Abstract</title> <bold>Objectives:</bold> The COVID-19 pandemic poses ongoing challenges to global public health systems, emphasizing the critical necessity for efficient diagnostic and prognostic markers. This study evaluates MAGLUMI® SARS-CoV-2 Ag N protein chemiluminescent immunoassay (MAG-CLIA) its analytical performance role in predicting disease severity prognosis among severe patients with comorbidities. <bold>Methods:</bold> Analytical validation of plasma MAG-CLIA encompassed...