A5101543546- Cancer-related molecular mechanisms research
- Lung Cancer Diagnosis and Treatment
- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Lung Cancer Treatments and Mutations
- Head and Neck Cancer Studies
- Cancer, Hypoxia, and Metabolism
- Metabolism, Diabetes, and Cancer
- Esophageal Cancer Research and Treatment
- Tracheal and airway disorders
- Gastric Cancer Management and Outcomes
- Lung Cancer Research Studies
- Cancer Immunotherapy and Biomarkers
- MicroRNA in disease regulation
- Adipose Tissue and Metabolism
- Cancer Cells and Metastasis
- Radiomics and Machine Learning in Medical Imaging
- Adipokines, Inflammation, and Metabolic Diseases
- Peptidase Inhibition and Analysis
- Epigenetics and DNA Methylation
- Tumors and Oncological Cases
- Immune cells in cancer
- Transplantation: Methods and Outcomes
- Neuroendocrine Tumor Research Advances
- Cancer Genomics and Diagnostics
Zhejiang Center for Disease Control and Prevention
2025
Zhejiang Cancer Hospital
2025
The First Affiliated Hospital, Sun Yat-sen University
2016-2024
Zhongshan Hospital
2016-2024
Fudan University
2006-2024
Sun Yat-sen University
2016-2024
Binzhou University
2024
Binzhou Medical University
2024
Integrated Chinese Medicine (China)
2024
Weatherford College
2024
Purpose: This study used the Surveillance, Epidemiology, and End Results (SEER) data to investigate changes in incidence, treatment, survival of lung cancer from 1973 2015. Patients methods: The clinical epidemiological patients with were obtained SEER database. Joinpoint regression models estimate rate related survival. Results: From 2015, average incidence was 59.0/100,000 personyears. increased initially, reached a peak 1992, then gradually decreased. A higher observed males than females...
Abstract Targeting ferroptosis, an iron-dependent form of regulated cell death triggered by the lethal overload lipid peroxides, in cancer therapy is impeded our limited understanding intersection tumour’s metabolic feature and ferroptosis vulnerability. In present study, arginine identified as a ferroptotic promoter using metabolites library. This effect mainly achieved through arginine’s conversion to polyamines, which exerts their potent ferroptosis-promoting property H 2 O -dependent...
Abstract Background Lung cancer is one of the most common tumors in world, and metastasis major causes tumor-related death lung patients. Tumor-associated macrophages (TAMs) are a component tumor microenvironment (TME) frequently associated with human cancers. However, regulatory mechanisms TAMs remain unclear. Methods Single-cell sequencing analysis normal tissues from public databases 14 patients who underwent surgery at Zhongshan Hospital was performed. In vitro co-culture experiments...
BackgroundEsophageal squamous cell carcinoma (ESCC) is among the most prevalent causes of cancer-related death in adults. Tumor microenvironment (TME) has been associated with therapeutic failure and lethal outcomes for patients. However, published reports on heterogeneity TME ESCC are scanty.MethodsFive tumor samples five corresponding non-malignant were subjected to scRNA-seq analysis. Bulk RNA sequencing data retrieved publicly available databases.FindingsFrom data, a total 128,688 cells...
As an early type of lung adenocarcinoma, ground glass nodule (GGN) has been detected increasingly and now accounts for most cancer outpatients. GGN a satisfactory prognosis its characteristics are quite different from solid adenocarcinoma (SADC). We compared the (GGN-ADC) with SADC using single-cell RNA sequencing (scRNA-seq) to fully understand GGNs. The tumor samples five patients GGN-ADCs SADCs underwent surgery were digested suspension analyzed 10× Genomic scRNA-seq techniques. obtained...
Abstract Background Lung adenocarcinoma (LUAD) patients with different American Joint Committee on Cancer stages have overall 5‐year survival rates. The tumor microenvironment (TME) and intra‐tumor heterogeneity (ITH) been shown to play a crucial role in the occurrence development of tumors. However, TME ITH lesions LUAD not extensively explored. Methods We present 204,157‐cell catalog transcriptome 29 lung samples systematically explore LUAD. Traditional RNA sequencing data complete...
Background: Lung adenocarcinoma (LUAD), the major subtype of lung cancer, is among leading cause cancer-related death worldwide.Energy-related metabolic reprogramming metabolism a hallmark cancer shared by numerous types, including LUAD.Nevertheless, functional pathways and molecular mechanism which FAM83A-AS1 acts in have not been fully elucidated.Methods: We used transwell, wound-healing scratch assay, assays to explore effect LUAD cell lines.Western blotting, Co-IP assays, ubiquitination...
Lung adenocarcinoma (LUAD) is one of the most common malignancies worldwide. Combination chemotherapy with cisplatin (CDDP) plus pemetrexed (PEM) remains predominant therapeutic regimen; however, chemoresistance greatly limits its curative potential. Here, through CRISPR-Cas9 screening, we identified miR-6077 as a key driver CDDP/PEM resistance in LUAD. Functional experiments verified that ectopic overexpression desensitized LUAD cells to both cell lines and patient-derived xenograft models....
Most cancer cells have fundamentally different metabolic characteristics, particularly much higher glycolysis rates than normal tissues, which support the increased demand for biosynthesis and promote tumor progression. We found that transforming growth factor (TGF)-β plays a dual function in regulating cell proliferation non-small lung cancer.We used PET/MRI imaging system to observe glucose metabolism of subcutaneous tumors nude mice. Energy lines detected by Seahorse XFe96 outflow...
Purpose: Lung adenocarcinoma (LUAD) is the leading cause of cancer-related deaths worldwide.Although tumor cell-T cell interactions are known to play a fundamental role in promoting progression, these have not been explored LUAD.Methods: The 10x genomics single-cell RNA sequencing (scRNA-seq) and gene expression data LUAD patients were obtained from ArrayExpress, TCGA, GEO databases.scRNA-seq analyzed infiltrating cells, epithelial T cells identified microenvironment.Differentially expressed...
Esophageal squamous cell carcinoma (ESCC) is the most common pathological type of esophageal cancer in China, accounting for more than 90 %. Most patients were diagnosed with advanced-stage ESCC, whom new adjuvant therapy recommended. Therefore, it urgent to explore therapeutic targets ESCC. Ferroptosis, a newly discovered iron-dependent programmed death, has been shown play an important role carcinogenesis by many studies. This study explored effect Polo like kinase 1 (PLK1) on...
Lung cancer is the main reason for cancer-associated death globally, and lung adenocarcinoma (LUAD) most prevalent subtype of cancer. Recently, AGRN considered playing an vital role in development some cancers. However, regulatory effects mechanisms LUAD remain elusive. In this study, we clarified significant upregulation expression by single-cell RNA sequencing combined with immunohistochemistry. Besides, confirmed that patients high are more susceptible to lymph node metastases have a...
Immune infiltration may predict survival and have clinical significance in lung cancer. However, immune signatures derived from profiling based on bulk tumor transcriptomes not been systematically established adenocarcinoma. We aimed to construct an cell infiltrating score, using a new algorithm for evaluating infiltration, improve the prognostic model of Public datasets adenocarcinoma Gene Expression Omnibus The Cancer Genome Atlas were adopted as training validation cohorts. Fractions...
Radiotherapy is an effective approach for the treatment of lung adenocarcinoma.However, evidence suggests that adenocarcinoma can easily develop tolerance to radiotherapy.The purpose this study was investigate effect and mechanism SMAD3 on radiosensitivity in vitro vivo.We found knockdown using two short hairpin RNAs lentivirus vectors significantly inhibited cell growth increased lines A549, H1299, H1975.Using RNA sequencing bioinformatics analyses, we differentially expressed genes cells...
Abstract Previous studies have identified potential risk factors for pulmonary carcinoid tumors and evaluated the effect of various treatments; however, results were not entirely consistent. We conducted a population‐based study to further explore relevant prognostic issues. extracted cases with from Surveillance Epidemiology End Results database. Cox proportional hazard regression was utilized identify significant factors, which helped establish nomogram predicting long‐term survival....
Cutaneous melanoma (CM) is the deadliest form of skin cancer. Numerous studies have revealed that microRNAs (miRNAs) are expressed abnormally in tissues. Our work aimed to assess multiple miRNAs using bioinformatic analysis order predict prognoses cutaneous patients.The microarray dataset GSE35579 was downloaded from Gene Expression Omnibus (GEO) database detect differential expression (DEMs), including 41 (primary and metastatic) tissues 11 benign nevi. Clinical information miRNA sequencing...