A5001649087- Research in Cotton Cultivation
- Dental materials and restorations
- Microbial Metabolic Engineering and Bioproduction
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- MicroRNA in disease regulation
- Microwave-Assisted Synthesis and Applications
- Bacterial Genetics and Biotechnology
- Enhanced Oil Recovery Techniques
- Topic Modeling
- Circular RNAs in diseases
- Dental Erosion and Treatment
- Hydraulic Fracturing and Reservoir Analysis
- Advanced Text Analysis Techniques
- Metal Extraction and Bioleaching
- Biofuel production and bioconversion
- Enzyme Catalysis and Immobilization
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Natural Language Processing Techniques
- Sentiment Analysis and Opinion Mining
- Stock Market Forecasting Methods
- Advanced Photocatalysis Techniques
- Materials Engineering and Processing
- Text and Document Classification Technologies
- Granular flow and fluidized beds
Fudan University
2018-2024
Cotton Research Institute
2022-2023
Chinese Academy of Agricultural Sciences
2019-2023
University of Jinan
2018-2023
Ministry of Ecology and Environment
2021-2023
Zhongshan Hospital
2018-2023
The First Affiliated Hospital, Sun Yat-sen University
2018-2023
Sun Yat-sen University
2018-2023
Huazhong Agricultural University
2023
Beijing University of Chemical Technology
2019-2022
Polyploidy complicates transcriptional regulation and increases phenotypic diversity in organisms. The dynamics of genetic gene expression between coresident subgenomes polyploids remains to be understood. Here we document the fiber development allotetraploid cotton Gossypium hirsutum by sequencing 376 genomes 2,215 time-series transcriptomes. We characterize 1,258 genes comprising 36 modules that control staged uncover components governing their partitioned relative subgenomic duplicated...
Bone metastasis (BM) has long been recognized as a major threat to the quality of life hepatocellular cancer (HCC) patients. While LncRNA34a (Lnc34a) shown regulate colon stem cell asymmetric division, its effect on HCC BM remains unknown.In situ hybridization and quantitative real-time polymerase chain reaction (qRT-PCR) were used detect expression Lnc34a in tissues lines. Ventricle injection model was constructed explore vivo. The methylation miR-34a promoter histones deacetylation...
Abstract The role of circular RNA (circRNA) in radiation‐induced liver disease (RILD) remains largely unknown. In this study, Ras‐related C3 botulinum toxin substrate 1 (RAC1) was elevated irradiated human hepatic stellate cell (HSC) line LX2, the important effector mediating RILD. Overexpression RAC1 promotes proliferation, proinflammatory cytokines production, and α‐smooth muscle actin expression, which were blocked by microRNA (miR)‐146a‐5p mimics. CircRNA RSF1 (circRSF1) upregulated LX2...
Radiotherapy is an effective approach for the treatment of lung adenocarcinoma.However, evidence suggests that adenocarcinoma can easily develop tolerance to radiotherapy.The purpose this study was investigate effect and mechanism SMAD3 on radiosensitivity in vitro vivo.We found knockdown using two short hairpin RNAs lentivirus vectors significantly inhibited cell growth increased lines A549, H1299, H1975.Using RNA sequencing bioinformatics analyses, we differentially expressed genes cells...
The regular-shaped SiO<sub>2</sub>-ZnO complex clusters constructed by spray-draying technology can enhance antibacterial activity while maintaining the mechanical and aesthetic properties of dental resin composites.
The functions and molecular mechanism of circRNAs in the development radiation-induced liver disease (RILD) remain largely unknown. goal this study was to explore expression potential role a new circular RNA, named circTUBD1, irradiated lipopolysaccharide (LPS)-stimulated human hepatic stellate cell (HSC) line LX-2 cells. circTUBD1 significantly upregulated LPS-stimulated cells compared non-treated To small interfering RNAs targeting were designed. Silencing inhibited proliferation, promoted...
The size and structure of inorganic fillers have a significant effect on the mechanical properties dental resin composites. In this work, we report use spray-drying for efficient construction SiO2 colloidal nanoparticle clusters (SCNCs) as novel fillers, yielding spherical closely packed structures with diameters 1–3 μm. superior performance composites can be obtained by filling 70 wt % SCNCs assembled 60 nm silica colloids building blocks in matrix. As compared to microparticles similar...
Background A thymoma is a common cancer within the anterior mediastinum; however, prognostic characteristics have not been established. The aim of this study was to identify factors and develop nomogram for prediction patients with based on data from Surveillance, Epidemiology, End Results (SEER) database. Methods Patients thymomas diagnosed between 1983 2014 were selected. Overall survival (OS) estimated using Kaplan–Meier method log‐rank test. Univariate multivariate Cox proportional...
Multifunctional fillers are greatly required for dental resin composites (DRCs). In this work, a spray dryer with three-fluid nozzle was applied the first time to construct high-performance complex nanoparticle clusters (CNCs) consisting of different functional nanofillers restoration. The application can effectively avoid aggregation nanoparticles opposite zeta potentials before drying process in order regularly shaped CNCs. For SiO2–ZrO2 binary system, CNCs constructed using maintained...
Male sterility is a valuable trait for genetic research and production application of wheat (Triticum aestivum L.). NWMS1, novel typical genic male mutant, was obtained from Shengnong 1, mutagenized with ethyl methane sulfonate (EMS). Microstructure ultrastructure observations the anthers microspores indicated that pollen abortion NWMS1 started at early uninucleate microspore stage. Pollen grain collapse, plasmolysis, absent starch grains were three characteristics abnormal microspores. The...
Upland cotton (Gossypium hirsutum L.) is the most economically important species in genus spp.). Enhancing yield a major goal breeding programs. Lint percentage (LP) and boll weight (BW) are two components of lint yield. The identification stable effective quantitative trait loci (QTLs) will aid molecular cultivars with high yield.Genotyping by target sequencing (GBTS) genome-wide association study (GWAS) 3VmrMLM were used to identify LP BW related QTLs from recombinant inbred line (RIL)...
Hepatic stellate cells (HSCs) are the main target of radiation damage and primarily contribute to development radiation-induced liver fibrosis. However, molecular events underlying activation HSCs not fully elucidated. In present study, human HSC line LX2 was treated with X-ray irradiation and/or TGF-β1, profibrogenic molecules were evaluated. The iTRAQ LC-MS/MS technology performed identify global protein expression profiles in following exposure different stimuli. Irradiation or TGF-β1...
Tillers not only determine plant architecture but also influence crop yield. To explore the miRNA regulatory network restraining tiller development in a dwarf-monoculm wheat mutant (dmc) derived from Guomai 301 (wild type, WT), we employed miRNome and transcriptome integrative analysis, real-time qRT-PCR, histochemistry, determinations of key metabolites photosynthesis parameters. A total 91 differentially expressed miRNAs (DEMs) were identified between dmc WT. Among them, 40 DEMs targeted...
The relationship between ubiquitin specific protease 7 (USP7) and radio-sensitivity in laryngeal squamous cell carcinoma (LSCC) has not been reported yet. Using gene chip Label-Free mass spectrometry, we found that USP7 was significantly increased both radioresistant LSCC patients cells receiving irradiation. Since p53 is the most important downstream of frequently mutated LSCC, investigated effects on radioresistance with or without mutation. We knockdown p53-mutated cells, while inhibiting...
Radiation-induced liver fibrosis (RILF), delayed damage to the (post-irradiation) remains a major challenge for radiotherapy of malignancies. This study investigated potential function and mechanism circTUBD1 in development RILF.By using dual luciferase assay, RNA pull-down assays, sequencing, chromatin immunoprecipitation (known as ChIP) series gain- or loss-of-function experiments, it was found that regulated activation response LX-2 cells induced by irradiation via...