A5100714607- Ferroptosis and cancer prognosis
- Cancer, Lipids, and Metabolism
- RNA modifications and cancer
- Retinoids in leukemia and cellular processes
- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- Immune cells in cancer
- Cancer Genomics and Diagnostics
- Lung Cancer Research Studies
- Cancer Immunotherapy and Biomarkers
- Inflammatory mediators and NSAID effects
- Cancer Cells and Metastasis
- Radiomics and Machine Learning in Medical Imaging
- Single-cell and spatial transcriptomics
- Metabolism, Diabetes, and Cancer
- Head and Neck Cancer Studies
- Tracheal and airway disorders
- Esophageal Cancer Research and Treatment
- MicroRNA in disease regulation
- Metabolomics and Mass Spectrometry Studies
- Transplantation: Methods and Outcomes
- Medical Imaging and Pathology Studies
Wenzhou Medical University
2025
Ruian People's Hospital
2025
First Hospital of Shanxi Medical University
2025
Shanxi Medical University
2025
Zhongshan Hospital
2017-2024
Sun Yat-sen University
2017-2024
The First Affiliated Hospital, Sun Yat-sen University
2017-2024
Fudan University
2017-2024
Army Medical University
2021-2022
Guangzhou University of Chinese Medicine
2022
Purpose: This study used the Surveillance, Epidemiology, and End Results (SEER) data to investigate changes in incidence, treatment, survival of lung cancer from 1973 2015. Patients methods: The clinical epidemiological patients with were obtained SEER database. Joinpoint regression models estimate rate related survival. Results: From 2015, average incidence was 59.0/100,000 personyears. increased initially, reached a peak 1992, then gradually decreased. A higher observed males than females...
Abstract Targeting ferroptosis, an iron-dependent form of regulated cell death triggered by the lethal overload lipid peroxides, in cancer therapy is impeded our limited understanding intersection tumour’s metabolic feature and ferroptosis vulnerability. In present study, arginine identified as a ferroptotic promoter using metabolites library. This effect mainly achieved through arginine’s conversion to polyamines, which exerts their potent ferroptosis-promoting property H 2 O -dependent...
Abstract Background Lung cancer is one of the most common tumors in world, and metastasis major causes tumor-related death lung patients. Tumor-associated macrophages (TAMs) are a component tumor microenvironment (TME) frequently associated with human cancers. However, regulatory mechanisms TAMs remain unclear. Methods Single-cell sequencing analysis normal tissues from public databases 14 patients who underwent surgery at Zhongshan Hospital was performed. In vitro co-culture experiments...
BackgroundEsophageal squamous cell carcinoma (ESCC) is among the most prevalent causes of cancer-related death in adults. Tumor microenvironment (TME) has been associated with therapeutic failure and lethal outcomes for patients. However, published reports on heterogeneity TME ESCC are scanty.MethodsFive tumor samples five corresponding non-malignant were subjected to scRNA-seq analysis. Bulk RNA sequencing data retrieved publicly available databases.FindingsFrom data, a total 128,688 cells...
As an early type of lung adenocarcinoma, ground glass nodule (GGN) has been detected increasingly and now accounts for most cancer outpatients. GGN a satisfactory prognosis its characteristics are quite different from solid adenocarcinoma (SADC). We compared the (GGN-ADC) with SADC using single-cell RNA sequencing (scRNA-seq) to fully understand GGNs. The tumor samples five patients GGN-ADCs SADCs underwent surgery were digested suspension analyzed 10× Genomic scRNA-seq techniques. obtained...
Abstract Background Lung adenocarcinoma (LUAD) patients with different American Joint Committee on Cancer stages have overall 5‐year survival rates. The tumor microenvironment (TME) and intra‐tumor heterogeneity (ITH) been shown to play a crucial role in the occurrence development of tumors. However, TME ITH lesions LUAD not extensively explored. Methods We present 204,157‐cell catalog transcriptome 29 lung samples systematically explore LUAD. Traditional RNA sequencing data complete...
Background: Lung adenocarcinoma (LUAD), the major subtype of lung cancer, is among leading cause cancer-related death worldwide.Energy-related metabolic reprogramming metabolism a hallmark cancer shared by numerous types, including LUAD.Nevertheless, functional pathways and molecular mechanism which FAM83A-AS1 acts in have not been fully elucidated.Methods: We used transwell, wound-healing scratch assay, assays to explore effect LUAD cell lines.Western blotting, Co-IP assays, ubiquitination...
Lung adenocarcinoma (LUAD) is one of the most common malignancies worldwide. Combination chemotherapy with cisplatin (CDDP) plus pemetrexed (PEM) remains predominant therapeutic regimen; however, chemoresistance greatly limits its curative potential. Here, through CRISPR-Cas9 screening, we identified miR-6077 as a key driver CDDP/PEM resistance in LUAD. Functional experiments verified that ectopic overexpression desensitized LUAD cells to both cell lines and patient-derived xenograft models....
Most cancer cells have fundamentally different metabolic characteristics, particularly much higher glycolysis rates than normal tissues, which support the increased demand for biosynthesis and promote tumor progression. We found that transforming growth factor (TGF)-β plays a dual function in regulating cell proliferation non-small lung cancer.We used PET/MRI imaging system to observe glucose metabolism of subcutaneous tumors nude mice. Energy lines detected by Seahorse XFe96 outflow...
Ferroptosis is an iron-dependent form of regulated cell death induced by the lethal overload lipid peroxides in cellular membranes. In recent years, modulating ferroptosis has gained attention as a potential therapeutic approach for tumor suppression. current study, retinol saturase (RETSAT) was identified significant mediator using publicly accessible CRISPR/Cas9 screening dataset. RETSAT depletion protected cells from peroxidation and subsequent triggered various inducers. Furthermore,...
EGF receptor (EGFR) tyrosine kinase inhibitors (TKIs) have achieved clinical success in lung adenocarcinoma (LUAD). However, tumors often show profound but transient initial response and then gain resistance. We identify transcription factor ZNF263 as being significantly decreased osimertinib-resistant or drug-tolerant persister LUAD cells residual tumors. overexpression improves the of delays formation with osimertinib treatment. further that binds recruits DNMT1 to EGFR gene promoter,...
Esophageal squamous cell carcinoma (ESCC) accounts for 90% of all cases esophageal cancers worldwide. Although neoadjuvant chemotherapy (NACT-ESCC) improves the survival ESCC patients, five-year rate these patients is dismal. The tumor microenvironment (TME) and heterogeneity decrease efficacy therapy. In our study, 113,581 cells obtained from five who underwent surgery alone (SA-ESCC) preoperative paclitaxel plus platinum (NACT-ESCC), were used scRNA-seq analysis to explore molecular...
Abstract Objectives Platinum-based chemotherapies are currently the first-line treatment of non-small cell lung cancer. This study will improve our understanding causes resistance to cisplatin, especially in adenocarcinoma (LUAD) and provide a reference for therapeutic decisions clinical practice. Methods Cancer Cell Line Encyclopedia (CCLE), The Genome Atlas (TCGA) Zhongshan hospital affiliated Fudan University (zs-cohort) were used identify multi-omics differences related platinum...
Lung adenocarcinoma (LUAD) is a high-risk malignancy. Telomeres- (TRGs) and aging-related genes (ARGs) play an important role in cancer progression prognosis. This study aimed to develop novel prognostic model combined TRGs ARGs signatures predict the prognosis of patients with LUAD. LUAD patient's sample data clinical were obtained from public databases. The was constructed evaluated using least absolute shrinkage selection operator (LASSO), multivariate Cox analysis, time-dependent...