A5078234998- Lung Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Medical Imaging and Pathology Studies
- Immune cells in cancer
- Cancer-related molecular mechanisms research
- Radiomics and Machine Learning in Medical Imaging
- Epigenetics and DNA Methylation
- Esophageal Cancer Research and Treatment
- Salivary Gland Tumors Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Cancer Cells and Metastasis
- Lung Cancer Research Studies
- MicroRNA in disease regulation
- Cancer Immunotherapy and Biomarkers
- Cancer, Hypoxia, and Metabolism
- Single-cell and spatial transcriptomics
- Gastric Cancer Management and Outcomes
- Advanced biosensing and bioanalysis techniques
- Metabolism, Diabetes, and Cancer
- Tracheal and airway disorders
- Circadian rhythm and melatonin
- Pleural and Pulmonary Diseases
- Metastasis and carcinoma case studies
Zhongshan Hospital
2015-2025
Fudan University
2015-2025
Southern Medical University
2025
Nanfang Hospital
2025
Sun Yat-sen University
2014-2024
The First Affiliated Hospital, Sun Yat-sen University
2014-2024
Guangxi University of Science and Technology
2024
Shanghai Institute of Technology
2024
University of Liverpool
2024
Tsinghua University
2024
MicroRNAs (miRNAs) have been identified as promising cancer biomarkers due to their stable presence in serum. As an alternative PCR-based homogenous assays, surface-based electrochemical biosensors offer great opportunities for low-cost, point-of-care tests (POCTs) of disease-associated miRNAs. Nevertheless, the sensitivity miRNA sensors is often limited by mass transport and crowding effects at water-electrode interface. To address such challenges, we herein report a DNA nanostructure-based...
As an early type of lung adenocarcinoma, ground glass nodule (GGN) has been detected increasingly and now accounts for most cancer outpatients. GGN a satisfactory prognosis its characteristics are quite different from solid adenocarcinoma (SADC). We compared the (GGN-ADC) with SADC using single-cell RNA sequencing (scRNA-seq) to fully understand GGNs. The tumor samples five patients GGN-ADCs SADCs underwent surgery were digested suspension analyzed 10× Genomic scRNA-seq techniques. obtained...
Abstract Background Lung adenocarcinoma (LUAD) patients with different American Joint Committee on Cancer stages have overall 5‐year survival rates. The tumor microenvironment (TME) and intra‐tumor heterogeneity (ITH) been shown to play a crucial role in the occurrence development of tumors. However, TME ITH lesions LUAD not extensively explored. Methods We present 204,157‐cell catalog transcriptome 29 lung samples systematically explore LUAD. Traditional RNA sequencing data complete...
Most cancer cells have fundamentally different metabolic characteristics, particularly much higher glycolysis rates than normal tissues, which support the increased demand for biosynthesis and promote tumor progression. We found that transforming growth factor (TGF)-β plays a dual function in regulating cell proliferation non-small lung cancer.We used PET/MRI imaging system to observe glucose metabolism of subcutaneous tumors nude mice. Energy lines detected by Seahorse XFe96 outflow...
EGF receptor (EGFR) tyrosine kinase inhibitors (TKIs) have achieved clinical success in lung adenocarcinoma (LUAD). However, tumors often show profound but transient initial response and then gain resistance. We identify transcription factor ZNF263 as being significantly decreased osimertinib-resistant or drug-tolerant persister LUAD cells residual tumors. overexpression improves the of delays formation with osimertinib treatment. further that binds recruits DNMT1 to EGFR gene promoter,...
Our study aimed to validate pathologic findings of ground-glass nodules (GGOs) different consolidation tumor ratios (CTRs), and explore whether GGOs could be stratified according CTR with an increment 0.25 based on its prognostic role.We retrospectively evaluated patients clinical stage IA who underwent curative resection between 2011 2016. The were divided into 4 groups step by 0.25. Cumulative survival rates calculated the Kaplan-Meier method. Univariate multivariate Cox regression...
The fourth Machine Learning for Health (ML4H) symposium was held in person on December 15th and 16th, 2024, the traditional, ancestral, unceded territories of Musqueam, Squamish, Tsleil-Waututh Nations Vancouver, British Columbia, Canada. included research roundtable sessions to foster discussions between participants senior researchers timely relevant topics ML4H community. organization roundtables at conference involved 13 27 junior chairs across tables. Each session an invited chair (with...
Immune-related adverse reactions (irAEs) are common after immune checkpoint inhibitor treatment, impacting the universality and continued use of immunotherapy. Currently, preclinical models to investigate mechanisms underlying these effects inadequate. This study aims develop both in vitro vivo irAEs advance basic research on reactions. For models, we designed two co-culture systems: "Lung epithelial cells-PBMC" conditional model "organoid-PBMCs" model. These involve culturing spheroids,...
We compared the overall survival (OS) and cancer-specific (CSS) of patients who received radiotherapy surgery, respectively, in a large population. In this study, we counted diagnosed with stage IA lung adenocarcinoma SEER database from 2015 to 2019. through Kaplan Meier analysis, balanced differences primary data propensity score matching (PSM), screened independent prognostic factors Cox regression then different treatment methods hierarchical analysis. Among 11,159 adenocarcinoma, 4254...
Abstract Background The optimal treatment for pulmonary mucoepidermoid carcinoma (MEC), a rare type of tumor, has not been established yet. This study analyzed the survival MEC patients and attempted to find clues treatment. Methods A total 21 with from November 2004 January 2011 were included in investigation. Immunohistochemistry, epidermal growth factor receptor (EGFR) mutation, retrospectively studied. Results Among patients, 17 diagnosed low-grade malignancy 4 high-grade through...
In order to identify novel non-invasive biomarkers with high accuracy for the screening of non-small cell lung cancer (NSCLC), we investigated predictive power 4 microRNAs (miR-146, miR-204, miR-106a and miR-124) in plasma samples obtained from patients NSCLC healthy controls (n=50; training phase) by reverse transcription-quantitative polymerase chain reaction (RT-qPCR). We found that levels miR-204 were significantly dysregulated compared controls, thus this miRNA was selected further...
Immune infiltration may predict survival and have clinical significance in lung cancer. However, immune signatures derived from profiling based on bulk tumor transcriptomes not been systematically established adenocarcinoma. We aimed to construct an cell infiltrating score, using a new algorithm for evaluating infiltration, improve the prognostic model of Public datasets adenocarcinoma Gene Expression Omnibus The Cancer Genome Atlas were adopted as training validation cohorts. Fractions...
Abstract Background The computed tomography (CT) characteristic of ground glass opacity (GGO) were shown to be associated with clinical significance in lung adenocarcinoma. We evaluated the prognostic value solid component ratio GGO IA invasive Methods retrospectively analyzed records patients who received surgical resection from April 2012 December 2015. was calculated based on thin-slice CT scans. Baseline features compared stratified by ratio. Cox proportional hazard models and survival...
Objective: We aimed to explore the prognostic implication for non-small cell lung cancer (NSCLC) based on expression profiles of circadian clock-related genes (CCRGs), and describe changes immune infiltration functions related rhythm.Methods: Univariate multivariate Cox proportional hazard regression were performed determine a CCRGs risk-score significantly correlated with overall survival (OS) training set validation set.GO, KEGG, GSVA indicated discrepant in cellular processes signaling...
In this study, we explored the gene and microRNA (miRNA) expressions profile of esophageal carcinoma. The expression data for messenger RNAs miRNAs in normal cancerous tissues were obtained from Cancer Genome Atlas database then differentially expressed genes identified. As a result, identified 2962 45 carcinoma compared with tissues. Subsequently, altered functions signaling pathways investigated using ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) analyses, these significantly...