A5045878729- RNA modifications and cancer
- Virology and Viral Diseases
- Viral Infections and Vectors
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- MicroRNA in disease regulation
- Viral Infections and Immunology Research
- Gut microbiota and health
- Insect symbiosis and bacterial influences
- Cancer Cells and Metastasis
- Cancer-related gene regulation
- Molecular Biology Techniques and Applications
- Vector-Borne Animal Diseases
- Pluripotent Stem Cells Research
- Cancer, Lipids, and Metabolism
- Mosquito-borne diseases and control
- Respiratory viral infections research
- Metabolomics and Mass Spectrometry Studies
- Transplantation: Methods and Outcomes
- Ubiquitin and proteasome pathways
- Cell death mechanisms and regulation
- Single-cell and spatial transcriptomics
- Garlic and Onion Studies
- Renal and related cancers
- Ferroptosis and cancer prognosis
Zhejiang Chinese Medical University
2021-2025
National Institute for Viral Disease Control and Prevention
2008-2024
YangPu Geriatric Hospital
2024
Luohe Medical College
2014-2023
Innovation Team (China)
2019-2023
Colby College
2022
Zhongshan Hospital
2009-2021
Fudan University
2009-2021
Sun Yat-sen University
2015-2021
Zhongshan Hospital of Xiamen University
2020-2021
Abstract Background Lung adenocarcinoma (LUAD) patients with different American Joint Committee on Cancer stages have overall 5‐year survival rates. The tumor microenvironment (TME) and intra‐tumor heterogeneity (ITH) been shown to play a crucial role in the occurrence development of tumors. However, TME ITH lesions LUAD not extensively explored. Methods We present 204,157‐cell catalog transcriptome 29 lung samples systematically explore LUAD. Traditional RNA sequencing data complete...
An outbreak of acute respiratory tract infection occurred in Shanxi Province, China, from March to April 2006. Of the 254 patients affected by this outbreak, 247 were students a senior high school; 1 these died during outbreak. Serological tests and blood culture revealed no evidence bacterial infection. The results direct reverse transcription-PCR or PCR performed with clinical specimens collected patients, including sole patient who died, positive for human adenoviruses (HAdVs) but...
The present study aimed to investigate the role and underlying mechanisms of long non-coding RNA (lncRNA) muscleblind-like 1 antisense (MBNL1-AS1) in progression Prostate cancer (PCa). MBNL1-AS1 microRNA (miR)-181a-5p expression PCa tissues several human cell lines were analyzed, respectively, using StarBasev3.0 project RT-qPCR assay. After overexpression, proliferation, invasion migration were, evaluated CCK-8, colony formation, transwell wound healing assays. Dual luciferase assay used for...
In order to identify novel non-invasive biomarkers with high accuracy for the screening of non-small cell lung cancer (NSCLC), we investigated predictive power 4 microRNAs (miR-146, miR-204, miR-106a and miR-124) in plasma samples obtained from patients NSCLC healthy controls (n=50; training phase) by reverse transcription-quantitative polymerase chain reaction (RT-qPCR). We found that levels miR-204 were significantly dysregulated compared controls, thus this miRNA was selected further...
Abstract Objective: This study aimed to elucidate the effect of lipopolysaccharides/toll-like receptor 4 (LPS/TLR4) pathway on early atherosclerosis (AS) development and its associated changes in fecal metabolites, thereby providing an experimental foundation for strategies prevent treat AS. Methods: Twelve Tibetan miniature pigs aged 4–5 months were divided into normal control (NC) group AS (6 each). The assignment was primarily based body weight; Secondary criteria, including glucose,...
Abstract Radioresistance is an important factor affecting the radiotherapy effect of colorectal cancer (CRC). Allicin a versatile sulfur‐containing organic compound extracted from garlic ( Allium sativum L.), which has many pharmacological effects. However, allicin on sensitivity CRC not been confirmed. The present study to observe radiosensitivity effects and explore its mechanism in radiotherapy. proliferation inhibition combined with X‐ray HCT116 cells were measured by growth curve cell...
Bone degradation is a serious complication of chronic inflammatory diseases such as septic arthritis, osteomyelitis, and infected orthopedic implant failure. Effective therapeutic treatments for bacteria-caused bone destruction are limited. In previous study, we found that lipopolysaccharide (LPS) induced osteoblast apoptosis inhibited early late-stage differentiation osteoblasts via activation the C-Jun N-terminal kinase (JNK) pathway. This study aimed to investigate effect JNK inhibition...
Virologic surveillance is a critical component of measles management. One the criteria for verification elimination endemic genetic analysis wild-type viruses to demonstrate lack an indigenous genotype. Measles yet be eliminated in China, and genotype H1 has been detected continuously since virologic was initiated 1993. very active providing unique opportunity conduct detailed study evolution single, over timespan nearly two decades. Phylogenetic performed on 450 nt coding sequence...
To investigate the mechanisms of lung adenocarcinoma cell metastasis and provide a theoretical basis for in-depth study adenocarcinoma.A549 cells are incubated with different concentrations Furin inhibitor indicated times. The proliferation migration were confirmed MTT, colony formation, wound Healing Transwell assayes. Hochest 33342 / PI double staining was used to detect apoptosis. Cell apoptosis associated proteins analysed by enzyme-linked immunosorbent assay (ELISA) western blot.We have...
The social amoeba Dictyostelium discoideum is a predatory soil protist frequently used for studying host-pathogen interactions. A subset of D. strains isolated from persistently carry symbiotic
Based on accumulating evidence, Alzheimer's disease (AD) is related to hypercholesterolemia, gut microbiota, and host metabolites. GuanXinNing Tablet (GXN) an oral compound preparation composed of two Chinese herbs, Salvia miltiorrhiza Bge. Ligusticum chuanxiong Hort., both which exert neuroprotective effects. Nevertheless, the effect GXN AD unknown. In present study, we investigated whether alters cholesterol, amyloid-beta (Aβ), serum metabolites, oxidative stress, neuronal metabolism...
Abstract Genetic characterization of wild-type measles virus was studied using nucleotide sequencing the C-terminal region N protein gene and phylogenetic analysis on 59 isolates from 16 provinces China in 2004. The results showed that all belonged to genotype H1. 51 were cluster 1 8 2 Viruses both clusters distributed throughout without distinct geographic pattern. sequence predicted amino acid homologies H1 strains 96.5%–100% 95.7%–100%, respectively. report transmission pattern viruses...
Abstract Objectives To explore the clinical features, molecular characteristics, and immune landscape of lung adenocarcinoma patients with KEAP1/NFE2L2/CUL3 mutations. Methods The multi‐omics data from GDC‐TCGA LUAD project Cancer Genome Atlas (TCGA) database were downloaded Xena browser. estimate infiltration was implemented by using GSVA analysis CIBERSORT. status mutation in 50 samples our department detected Sanger sequencing, following relative expression level differentially expressed...
Background China experienced several large measles outbreaks in the past two decades, and a series of enhanced control measures were implemented to achieve goal elimination. Molecular epidemiologic surveillance wild-type viruses (MeV) provides valuable information about viral transmission patterns. Since 1993, virologic surveillnace has confirmed that single endemic genotype H1 have been predominantly circulating China. A component molecular is monitor genetic characteristics hemagglutinin...
Embryonic/germ cell traits are common in malignant tumors and thought to be involved tumor behaviors. The reasons why show strong embryonic/germline (displaced germ cells or gametogenic programming reactivation) controversial. Here, we that a chemical carcinogen, 3-methyl-cholanthrene (3-MCA), can trigger the germ-cell potential of human bone marrow-derived (hBMDCs). 3-MCA promoted generation cell-like from induced hBMDCs had undergone transformation, whereas similar results were not...
Abstract Background Tumor invasiveness reflects many biological changes associated with tumorigenesis, progression, metastasis, and drug resistance. Therefore, we performed a systematic assessment of invasiveness-related molecular features across multiple human cancers. Materials methods Multi-omics data, including gene expression, miRNA, DNA methylation, somatic mutation, in approximately 10,000 patients 30 cancer types from The Cancer Genome Atlas, Gene Expression Omnibus, PRECOG, our...
Introduction The Hedi virus (HEDV) and Wuxiang (WUXV) are newly discovered Bunyaviruses transmitted by sandflies. geographical distribution of isolation these two viruses continues to expand it has been reported that WUXV causes neurological symptoms even death in suckling mice. However, little is known about the prevalence mammalian infections. Methods In order understand infection status HEDV humans animals from regions where have isolated, this study used Western blotting detect positive...
ABSTRACT Context: Squalene epoxidase (SQLE) is overexpressed in a variety of tumors, which may play an important role their tumorigenesis, development, and prognosis. Aims: The aim this study to investigate the expression SQLE explore its clinicopathological significance gastric cancer. Settings Design: correlation between positive pathological characteristics patients (such as sex, age, tumor size, survival, differentiation, TNM staging, lymph node metastasis) was analyzed. Materials...
Objects: Inflammation is one of the hallmarks cancer. Tumor-associated inflammatory response plays a crucial role in enhancing tumorigenesis. This study aimed to establish an effective predictive nomogram based on inflammation factors patients with advanced non-small cell lung cancer (NSCLC). Methods: We retrospectively evaluated 887 NSCLC between November 2004 and December 2015 randomly divided them into primary (n = 520) validation cohorts 367). Cox regression analysis was used identify...