A5100609149- Advanced Biosensing Techniques and Applications
- Cancer-related molecular mechanisms research
- Immune Cell Function and Interaction
- RNA modifications and cancer
- Breast Cancer Treatment Studies
- Advanced biosensing and bioanalysis techniques
- T-cell and B-cell Immunology
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Monoclonal and Polyclonal Antibodies Research
- Leptospirosis research and findings
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Quantum Dots Synthesis And Properties
- Catalytic C–H Functionalization Methods
- RNA Research and Splicing
- Genomics and Phylogenetic Studies
- Nanofabrication and Lithography Techniques
- Synthesis and Catalytic Reactions
- Immune Response and Inflammation
- Anatomy and Medical Technology
- Sulfur-Based Synthesis Techniques
- Metabolomics and Mass Spectrometry Studies
- Advanced Fluorescence Microscopy Techniques
- Cancer, Lipids, and Metabolism
State Key Laboratory of Pollution Control and Resource Reuse
2021-2025
Tongji University
2021-2025
Northwestern Polytechnical University
2024
Zhengzhou University of Industrial Technology
2024
Second People’s Hospital of Huai’an
2016-2024
Xuzhou Medical College
2016-2024
Wuhan University
2008-2023
Renmin Hospital of Wuhan University
2012-2023
First Affiliated Hospital of Wenzhou Medical University
2022-2023
Wenzhou Medical University
2022-2023
Acetotrophic methanogens' dysfunction in anaerobic digestion under ammonia pressure has been widely concerned. Lipids, the main cytomembrane structural biomolecules, normally play indispensable roles guaranteeing cell functionality. However, no studies explored effects of high on acetotrophic lipids. Here, a high-throughput lipidomic interrogation deciphered lipid reprogramming representative acetoclastic methanogen (Methanosarcina barkeri) upon exposure. The results showed that...
Pancreatic cancer (PC) is an extremely malignant tumor with low survival rate. Effective biomarkers and therapeutic targets for PC are lacking. The roles of circular RNAs (circRNAs) in cancers have been explored various studies, however more work needed to understand the functional specific circRNAs. In this study, we explore role mechanism circ_0035435 (termed circCGNL1) PC.
Abstract Long noncoding RNAs (lncRNAs) are regarded as crucial regulators in tumor progression. Potassium two pore domain channel subfamily K member 15 and WISP2 antisense RNA 1 (KCNK15-AS1) has been confirmed to inhibit the migration invasion of pancreatic cancer (PC) cells. However, its downstream mechanism effect on other cellular functions PC remain unknown. This study probed function potential KCNK15-AS1 cell growth. RT-qPCR western blot were employed measure gene expression ISH was...
Fast sulfonylation of pyridine/quinoline N-oxides induced by iodine is demonstrated herein. The regioselective protocol occurs under metal-free conditions in a short reaction time (10 min), exhibiting high efficiency (up to 92% yield) and good compatibility 33 examples). A gram-scale was conducted with only slight loss production.
Abstract WC1 proteins are uniquely expressed on γδ T cells and belong to the scavenger receptor cysteine-rich (SRCR) superfamily. While present in variable, sometimes high, numbers genomes of mammals birds, cattle there 13 distinct genes (WC1-1 WC1-13). All bovine can serve as coreceptors for TCR a tyrosine phosphorylation dependent manner, some required cell response Leptospira. We hypothesized that individual receptors encode Ag specificity via coligation bacteria with TCR. SRCR domain...
The present study aimed to investigate the role and underlying mechanisms of long non-coding RNA (lncRNA) muscleblind-like 1 antisense (MBNL1-AS1) in progression Prostate cancer (PCa). MBNL1-AS1 microRNA (miR)-181a-5p expression PCa tissues several human cell lines were analyzed, respectively, using StarBasev3.0 project RT-qPCR assay. After overexpression, proliferation, invasion migration were, evaluated CCK-8, colony formation, transwell wound healing assays. Dual luciferase assay used for...
Most patients with non–small cell lung cancer (NSCLC) do not achieve durable clinical responses from immune checkpoint inhibitors, suggesting the existence of additional resistance mechanisms. Nicotinamide adenine dinucleotide (NAD)–induced death (NICD) P2X7 receptor (P2X7R)–expressing T cells regulates homeostasis in inflamed tissues. This process is mediated by mono–adenosine 5′-diphosphate (ADP)–ribosyltransferases (ARTs). We found an association between membranous expression ART1 on...
Breast cancer (BC) is a heterogeneous tumor, and better understanding of its heterogeneity essential to improving treatment effect. Quantum dot (QD)-based immunofluorescent nanotechnology (QD-IHC) for molecular pathology has potential advantages in delineating tumor heterogeneity. This explored this paper by QD-IHC imaging HER2 ER. BC can be displayed more clearly sensitively than conventional IHC tissue microarrays. Furthermore, the simultaneous ER might help understand their interactions...
The present research aimed to evaluate the prognostic value of a novel risk classification microvascular invasion (MVI) in hepatocellular carcinoma (HCC) after resection.A total 295 consecutive HCC patients underwent hepatectomy were included our study. We evaluated degree MVI according following three features: number invaded microvessels (≤5 vs >5), invading cells (≤ 50 >50), distance from tumor edge (≤1 cm >1 cm).All divided into groups factors MVI: non-MVI group (n=180), low-MVI (n=60)...
A Gram reaction-negative, weakly motile, non-spore-forming, rod-shaped, aerobic bacterium designated strain JLT832(T) was isolated from surface water of the central Pacific Ocean and formed yellow colonies on rich organic (RO) medium. The oxidase-negative catalase-positive. Acid produced mannitol, glucose, sucrose, lactose, sorbitol, maltose, (+)-trehalose d-fructose. No acid d-(+)-xylose. major cellular fatty acids were C(18 : 1)ω7c, C(14 0) 2-OH C(16 0). polar lipids sphingoglycolipid,...
The immunohistochemical assessment of Ki67 antigen (Ki67) is the most widely practiced measurement breast cancer cell proliferation; however, it has some disadvantages and thus prognostic value in remains controversial. Our previous studies confirmed advantages quantum dots-based nanotechnology for quantitative analysis biomarkers compared with conventional immunohistochemistry (IHC). This study was designed to assess by dot-immunohistochemistry (QD-IHC) investigate score human epidermal...
Abstract Background WC1 co-receptors belong to the scavenger receptor cysteine-rich (SRCR) superfamily and are encoded by a multi-gene family. Expression of particular genes defines functional subpopulations + γδ T cells. We have previously identified partial or complete genomic sequences for thirteen different through annotation bovine genome Btau_3.1 build. also two cDNA from other cattle that did not correspond in Their absence build may reflected gaps assembly polymorphisms among...
Hepatocellular carcinoma (HCC), as the third leading cancer‐caused deaths, prevails with high mortality, and affects more than half a million individuals per year worldwide. A former study revealed that microRNA‐221 (miR‐221) was involved in cell proliferation of liver cancer HCC development. The current aims to evaluate whether miR‐221 targeting SOCS3 through JAK–STAT3 signaling pathway. series mimic, inhibitor, siRNA against , plasmids were introduced SMMC7721 cells highest expression...
We report here a fully organic, self-assembled dimeric receptor, constructed from acyclic naphthyridyl–polypyrrolic building blocks. The cagelike dimer is stable in the solid state, solution, and gas phase, as inferred X-ray diffraction spectroscopic analyses. This system acts receptor for oxalic acid, maleic malonic acid state THF solution. In contrast, acetic propionic adipic succinic with pKa values > ca. 2.8, were not bound effectively within cavity. It speculated that serve to protonate...
A Gram-negative, non-motile, rod-shaped bacterial strain, JLT354-W(T), that accumulates poly-beta-hydroxybutyrate granules was isolated from the South China Sea. Phylogenetic analysis based on 16S rRNA gene sequences showed strain related to members of genera Antarctobacter, Sagittula, Oceanicola and Loktanella; levels similarity between JLT354-W(T) above were less than 92.0 %. The predominant fatty acid C(18 : 1)omega7c (83.1 %); significant amounts 0) (7.9 %) C(12 1) 3-OH (3.7 also...