A5059711692- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Cancer, Stress, Anesthesia, and Immune Response
- Regulation of Appetite and Obesity
- Virus-based gene therapy research
- Cardiovascular Disease and Adiposity
- RNA modifications and cancer
- Lung Cancer Treatments and Mutations
- Cancer-related molecular mechanisms research
- Neuroinflammation and Neurodegeneration Mechanisms
- Pancreatic function and diabetes
- Neurogenesis and neuroplasticity mechanisms
- Viral Infectious Diseases and Gene Expression in Insects
- Nerve injury and regeneration
- Epigenetics and DNA Methylation
- Stress Responses and Cortisol
- Lung Cancer Research Studies
- Immune Cell Function and Interaction
- Lung Cancer Diagnosis and Treatment
- Diet and metabolism studies
- Cancer, Lipids, and Metabolism
- Dietary Effects on Health
- Tryptophan and brain disorders
- Metabolism, Diabetes, and Cancer
- RNA Interference and Gene Delivery
Hebei General Hospital
2019-2025
The Ohio State University
2016-2025
State Key Laboratory for Innovation and Transformation of Luobing Theory
2025
Qilu Hospital of Shandong University
2025
The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute
2018-2024
West China Medical Center of Sichuan University
2024
Peking University
2024
Peking University People's Hospital
2024
Shanghai Ocean University
2024
Changchun University of Chinese Medicine
2024
Abstract Gut microbial dysbiosis contributes to the development of colorectal cancer (CRC). Here we catalogue communities in human gut mucosae at different stages tumorigenesis. We analyse mucosal microbiome 47 paired samples adenoma and adenoma-adjacent mucosae, 52 carcinoma carcinoma-adjacent 61 healthy controls. Probabilistic partitioning relative abundance profiles reveals that a metacommunity predominated by members oral is primarily associated with CRC. Analysis shows differences...
Objectives We aimed to characterise the microbial changes associated with histological stages of gastric tumourigenesis. Design performed 16S rRNA gene analysis mucosal samples from 81 cases including superficial gastritis (SG), atrophic (AG), intestinal metaplasia (IM) and cancer (GC) Xi’an, China, determine microbiome dysbiosis across GC. validated results in 126 Inner Mongolia, China. Results observed significant mucosa IM GC subjects, enrichment 21 depletion 10 bacterial taxa compared SG...
Obesity is frequently associated with impairments in the social domain, and stress at puberty can lead to long-lasting changes visceral fat deposition behaviors. However, whether stress-induced adipose tissue affect fat-to-brain signaling, thereby orchestrating behavioral changes, remains unknown. We found that peripubertally stressed male—but not female—mice exhibit concomitant increased adiposity sociability deficits. show reduced levels of adipokine nicotinamide phosphoribosyltransferase...
Brown adipose tissue (BAT) activation and subcutaneous white fat browning are essential components of the thermogenic response to cold stimulus in mammals. microRNAs have been shown regulate both processes cis. Here, we identify miR-32 as a BAT-specific super-enhancer-associated miRNA mice that is selectively expressed BAT further upregulated during exposure. Inhibiting vivo led impaired tolerance, decreased thermogenesis, compromised result reduced serum FGF21 levels. Further examination...
Abstract Living in an enriched environment (EE) decreases adiposity, increases energy expenditure, causes resistance to diet induced obesity, and induces brown-like (beige) cells white fat via activating a hypothalamic-adipocyte axis. Here we report that EE stimulated vascular endothelial growth factor (VEGF) expression depot-specific manner prior the emergence of beige cells. The VEGF up-regulation was independent hypoxia but required intact sympathetic tone adipose tissue. Targeted...
Numerous studies have found that chronic stress could promote tumor progression and this may be related to inhibtion of immune system. Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population with immunosuppressive activity. MDSCs represent key link between progression. However, the role stress-induced in breast cancer is unclear. The present study showed pre-exposure lead elevation facilitated metastasis tumor-bearing mice. Adoptive transfer significantly increase lung...
Environmental enrichment (EE) is a housing environment for mice that boosts mental and physical health compared to standard laboratory housing. Our recent studies demonstrate environmental decreases adiposity, increases energy expenditure, resists diet induced obesity, causes cancer remission inhibition in mice. EE typically consists of larger living space, variety 'toys' interact with, running wheels, can include number other novel changes. All this fosters more complex social engagement,...
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a member of the subtilisin family PCs that encodes neural apoptosis-regulated 1. However, precise role PCSK9 in lung cancer cell apoptosis has remained elusive. In present study, A549 human adenocarcinoma cells were transfected with small interfering (si)RNA to investigate underlying mechanisms apoptosis. The results indicated siRNA exhibited anti-tumor activity by inducing as determined Cell Counting Kit-8 and Hoechst staining...
Abstract Macroenvironmental factors, including a patient's physical and social environment, play role in cancer risk progression. Our previous studies show that living an enriched environment (EE) providing complex stimuli confers anticancer phenotype mice mediated, part by specific neuroendocrine axis, with brain-derived neurotrophic factor (BDNF) as the key brain mediator. Here, we investigated how EE modulated T-cell immunity its EE-induced effects. data demonstrated CD8 T cells were...
Zinc-finger protein 471 (ZNF471) was preferentially methylated in gastric cancer using promoter methylation array. The role of ZNF471 human is unclear. Here we elucidated the functional significance, molecular mechanisms and clinical impact cancer. mRNA silenced 15 out 16 cell lines due to hypermethylation. Significantly higher also observed primary cancers compared their adjacent normal tissues (P < 0.001). CpG-site hypermethylation correlated with poor survival patients (n = 120, P Ectopic...
Promoter methylation plays a vital role in tumorigenesis through transcriptional silencing of tumor suppressive genes. Using genome-wide array, we first identified PBX/Knotted Homeobox 2 (PKNOX2) as candidate suppressor gastric cancer. PKNOX2 mRNA expression is largely silenced cancer cell lines and primary via promoter methylation. was associated with poor survival patients. A series vitro vivo functional studies revealed that functions suppressor. Ectopic inhibited proliferation GC...
Aging is associated with increased central nervous system inflammation, in large part due to dysfunctional microglia. Environmental enrichment (EE) provides a model for studying the dynamics of lifestyle factors development age-related neuroinflammation and microglial dysfunction. EE results improvements learning memory, metabolism, mental health variety animal models. We recently reported that implementing middle age promotes healthy aging. In present study, we investigated whether...