A5033213972- Gut microbiota and health
- Clostridium difficile and Clostridium perfringens research
- Dietary Effects on Health
- Diet and metabolism studies
- Epigenetics and DNA Methylation
- Cancer Immunotherapy and Biomarkers
- Drug-Induced Adverse Reactions
- Pharmacovigilance and Adverse Drug Reactions
- Blood disorders and treatments
- Glycosylation and Glycoproteins Research
- Liver Disease Diagnosis and Treatment
- Ubiquitin and proteasome pathways
- Probiotics and Fermented Foods
- COVID-19 Clinical Research Studies
- Nutritional Studies and Diet
- Genetics and Neurodevelopmental Disorders
- MicroRNA in disease regulation
- Neuroinflammation and Neurodegeneration Mechanisms
- Alcohol Consumption and Health Effects
- Diet, Metabolism, and Disease
- Bone Metabolism and Diseases
- Urinary Bladder and Prostate Research
- Urinary Tract Infections Management
- Gastrointestinal motility and disorders
- Quality and Safety in Healthcare
Hubei University of Medicine
2025
Tongde Hospital of Zhejiang Province
2024
Zhejiang Academy of Forestry
2024
Jilin University
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Peking Union Medical College Hospital
2024
Fudan University
2018-2023
Minhang District Central Hospital
2018-2023
China Medical University
2021
The First Affiliated Hospital, Sun Yat-sen University
2019
Background: Anti-PD-1-based immunotherapy has emerged as a promising therapy for several cancers. However, it only benefits small subset of colorectal cancer (CRC) patients. Mounting data supports the pivotal role gut microbiota in shaping immune system. Pectin, widely consumed soluble fiber, been reported to ameliorate imbalance microbiota. Therefore, we aimed explore effect and underlying mechanisms pectin improving anti-PD-1 mAb efficacy. Methods: The C57BL/6 mice were treated with...
The gut microbiota was emerging as critical regulatory elements in shaping the outcome of cancer immunotherapy. However, underlying mechanisms by which commensal species enhance antitumor immunity remain largely unexplored. Here, we show that from healthy individuals conferred considerable sensitivity to anti-PD-1 colorectal (CRC) tumor-bearing mice, whereas CRC patients failed do so. By 16S rRNA gene sequencing, identified Lactobacillus significantly increased mice with good response...
Dietary intake of probiotic yogurt, which has beneficial effects on intestinal microecology, is associated with a lower incidence hypertension. Recent studies have shown that the gut microbiota plays vital role in development However, impact antihypertensive effect yogurt remains unclear. Here, we evaluated spontaneously hypertensive rats (SHR). SHR were treated (0.2 mL per 100 g body weight) (SHR-Y group) for seven weeks and compared whole milk-treated (SHR normotensive Wistar-Kyoto (WKY...
Natural polyphenols may have a role in counteracting oxidative stress, which is associated with aging and several bone-related diseases. Chlorogenic acid (CGA) naturally occurring polyphenolic compound formed by the esterification of caffeic quininic acids osteogenic, antioxidant, anti-inflammatory properties. This review discusses potential CGA to enhance osteogenesis increasing osteogenic capacity mesenchymal stem cells (MSCs), osteoblast survival, proliferation, differentiation,...
The presence of tertiary lymphoid structures (TLSs) has been correlated with improved prognosis and clinical outcomes in response to immunotherapy certain solid tumors. However, the precise role TLSs lung adenocarcinoma (LUAD) remains unclear. Four datasets LUAD were obtained from Cancer Genome Atlas (TCGA) Gene Expression Omnibus (GEO). model was constructed using a multivariate Cox proportional hazards model. GO KEGG analyses performed explore biological process associated ESTIMATE...
Abstract Background and Aims Antibiotics (ATBx) acetaminophen (APAP) are widely used worldwide. APAP is the most common cause of acute liver injury (ALI) might be in combination with ATBx clinics. However, impact on APAP‐induced ALI has rarely been studied. Methods First, we compared effects seven ALI. Then, analysed faecal, serum samples to investigate gut microbiota this process. Finally, assessed role short‐chain fatty acids Results In work, found that was significantly aggravated mice...
BACKGROUND This study aimed to investigate the association of single nucleotide polymorphisms (SNPs) Forkhead box O3 (FOXO3) gene with type 2 diabetes mellitus (T2D). MATERIAL AND METHODS A total 843 elderly residents from east China were enrolled in this study, which included 426 patients and 417 controls. Four SNPs analyzed by qPCR. Genotype frequencies 4 FOXO3 controls using logistic regression analysis. The between each SNP clinical indicators was linear RESULTS None variants,...
Background Calorie restriction (CR) is a therapeutically effective method for nonalcoholic fatty liver disease. However, the compliance of CR relatively poor. New methods are needed. Methods and Results Each week, mice given 5‐day high‐fat diet (HFD) ad libitum plus 2 days an intermittent calorie (ICR) (50% restriction) consisting yogurt, fruit, vegetables, 16 weeks. The effect ICR model on examined. Compared with continuous HFD‐fed mice, feeding HFD+ICR have lower body weight hepatic...
Psoriasis is a chronic autoinflammatory skin disease, and its aetiology remains incompletely understood. Recently, gut microbial dysbiosis found to be tightly associated with psoriasis.We sought reveal the causal role of microbiota in psoriasis pathogenesis investigate protective effect healthy commensal bacteria against imiquimod -induced psoriasis-like response.By using fecal transplantation (FMT), 16S rRNA gene-based taxonomic profiling Lactobacillus supplement, we have assessed FMT from...
Nonalcoholic steatohepatitis (NASH) is the major cause of liver dysfunction. Animal and population studies have shown that mitochondrial aldehyde dehydrogenase (ALDH2) implicated in fatty disease. However, role ALDH2 NASH underlying mechanisms remains unclear. To address this issue, knockout (ALDH2-/-) mice wild-type littermate were fed a methionine-and choline-deficient (MCD) diet to induce model. Fecal, serum, samples collected analyzed investigate impact gut microbiota bile acids on...
Pulmonary embolism (PE) is a common and potentially fatal condition in the emergency department, early identification of modifiable risk factors for prevention management highly desirable. Although gut dysbiosis associated with high incidence venous thromboembolism, role mechanisms microbiome pathogenesis especially PE, remain unexplored. Here, we attempted to elucidate benefits PE using multiple antibiotics fecal microbiota transplantation (FMT) intervention classical mouse model PE. The...
Several pharmacological agents, such as chloroquine/hydroxychloroquine, have been promoted for COVID-19 treatment or pre-exposure prophylaxis. However, no comprehensive evaluation of the safety these possible agents is available, and urgently needed. The purpose this study was to investigate risks cardiac adverse events associated with pharmacotherapies COVID-19, including certain antimalarial, antiviral, antibiotic drugs. We conduced retrospective pharmacovigilance analyses US Food Drug...
Essential hypertension is a leading global public health issue, billions of people suffered from it every year. Recently, multiple evidence suggests that DNA methylation play an important role in regulating blood pressure. Here, we tested the risk for essential conferred by single nucleotide polymorphisms (SNPs) within methyltransferase 1 (DNMT1). Three loci (rs2228611, rs2228612, and rs16999593) were selected to be analyzed 3410 cases 1307 normal controls southern Chinese aged 60 or above....
Objective: To investigate the correlation between patatin-like phospholipase domain-containing 3 (PNPLA3) rs738409 and transmembrane 6 superfamily member 2 (TM6SF2) rs58542926 gene polymorphisms incidence of primary liver cancer in Han population China's Northeast region. Methods: A case-control study was used to enroll 521 patients with as case group 164 healthy people control group. The divided into groups without cirrhosis according etiology. polymerase chain reaction (PCR) method detect...
Objective To investigate the association of functional single-nucleotide polymorphisms (SNPs) in SCGB3 A2 promoter with susceptibility to Graves' disease (GD).Methods Functional analysis was carried out vivo and vitro pSNPs (SNP76,SNP75,and SNP74) by means luciferase assays,real-time reverse transcriptase-polymerase chain reaction,and allele-specific transcript quantification.Results The activities pGL3-(SNP76 + SNP75),pGL3-(SNP76 SNP74),and SNP75 were decreased.T allele able compete for...
Lactation mastitis seriously severely affects the health of lactating females and their infants, yet underlying causes clinical lactation remain unclear. In this study, we used microbiota-humanized mice as a model to investigate role gut microbiota in mastitis. We compared fecal patients healthy individuals conducted transplantation (FMT) experiments an antibiotic-pretreated mouse test whether microbes contribute human Our results showed that diversity was reduced dysbiosis present patients....