A5101518660- Esophageal Cancer Research and Treatment
- Pharmacological Effects of Natural Compounds
- Phytochemistry and biological activity of medicinal plants
- Metabolism, Diabetes, and Cancer
- Liver Disease Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Diet and metabolism studies
- Gastrointestinal motility and disorders
- Cancer-related molecular mechanisms research
- Genetic Syndromes and Imprinting
- Phytochemical Studies and Bioactivities
- Phytochemicals and Antioxidant Activities
- Genetic factors in colorectal cancer
- Ginger and Zingiberaceae research
- Horticultural and Viticultural Research
- Fibroblast Growth Factor Research
- Acupuncture Treatment Research Studies
- Ferroptosis and cancer prognosis
- Traditional Chinese Medicine Studies
- Fungal Biology and Applications
- Hops Chemistry and Applications
- Gastrointestinal Tumor Research and Treatment
- Natural Compounds in Disease Treatment
- Helicobacter pylori-related gastroenterology studies
- Mine drainage and remediation techniques
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Hefei National Center for Physical Sciences at Nanoscale
2024
University of Science and Technology of China
2024
Hulunbuir University
2024
University of Saskatchewan
2008-2023
Vancouver Biotech (Canada)
2023
Xinjiang Uygur Autonomous Region Education Department
2023
Qufu Normal University
2022
Sinopec (China)
2021
Yunnan University of Traditional Chinese Medicine
2008-2020
Introduction:Amomum villosum Lour., a herbaceous plant in the ginger family, has been proven to be effective treating gastrointestinal diseases. It listed Chinese Pharmacopeia as legal source of Amomi Fructus. In our previous study, we demonstrated that treatment with extracts A. prevented development and progression intestinal mucositis. current aimed verify explain potential beneficial effects on inflammatory bowel disease (IBD). Methods: The effect water (WEAV) volatile oil (VOAV) were...
Abstract Purpose: Esophageal cancer is one of the most aggressive and deadly forms cancer; highlighting need to identify biomarkers for early detection prognostic classification. Our recent studies have identified inflammatory gene microRNA signatures derived from tumor nontumor tissues as hepatocellular, lung, colorectal adenocarcinoma. Here, we examine relationship between expression these genes micro RNA (miRNA) in esophageal adenocarcinoma patient survival. Experimental Design: We...
Background . The dried mature fruit of Amomum villosum has been historically used in China as food and the auxiliary treatment digestive system disorders. Numerous studies have shown that gastrointestinal function is closely related to development nonalcoholic fatty liver disease via “gut-liver” axis. Objective present study aimed explore whether mechanism underlying regulation lipid accumulation (NAFLD) may affect disorders using active ingredients A. Design Male Sprague-Dawley rats on a...
To evaluate loss of imprinting (LOI) and expression the IGF2 gene in matched esophageal normal adenocarcinoma tissues, we studied a prospective cohort 77 patients who underwent resection between 1998 2003. status was determined by reverse transcription–polymerase chain reaction (PCR) following ApaI digestion, quantitative PCR used to expression, which correlated with clinicopathologic findings, disease-free overall survival. In total, 32% (14/44) informative tissues showed imprinting, strong...
The gut-liver axis is largely involved in the development of non-alcoholic fatty liver disease (NAFLD). We investigated whether 2, 3, 5, 4'-tetrahydroxy-stilbene-2-O-β-D-glucoside (TSG) could reverse NAFLD induced by a high-fat diet (HFD) and it did so via axis. Results showed that TSG reduce accumulation FFA reducing expression L-FABP FATP4. regulated gut microbiota balanced increased protein ZO-1 occludin, which improve function intestinal mucosal barrier serum LPS content about 25%....
Polygonum multiflorum Radix (PMR) has long history in hair growth promotion and coloring clinical applications. However, several crucial problems its clinic usage mechanisms are still unsolved or lack scientific evidences. In this research, C57BL/6J mice were used to investigate activity possible mechanism of PMR Preparata (PMRP). Hair activities investigated by length, covered skin ratio, the number follicles, color. Regulation effects cytokines involved procedure tested, such as fibroblast...
Polygonum multiflorum is a traditional Chinese medicine with long history in hair growth promotion and blackening. The purpose of the study was to examine effect mechanism C57BL/6 mice fade induced H 2 O used this research. Hair pigmentogenesis activities Multiflorum Radix (PMR, raw crude drug), Preparata (PMRP, processed their major chemical constituent TSG were investigated. regulation effects several cytokines enzymes such as POMC, α -MSH, MC1R, ASIP, MITF, TYR, TRP-1, TRP-2 PMR group...
Objective: This study evaluates the clinical significance of p53 mutations in oesophageal adenocarcinoma (EADC). Methods: Between February 1991 and 2006, 142 consecutive patients with EADC underwent potentially curative resection. No patient received induction therapy. Strict clinicopathologic criteria were used to define primary (Type I), excluding gastric cardia II). Genomic DNA was extracted from tumours, each matched histologically normal epithelium (internal control) resection margin....
Raw and processed Radix Polygoni Multiflori have been used in the prevention treatment of nonalcoholic fatty liver disease (NAFLD), hyperlipidemia, related diseases Asian counties for centuries. The lipid regulation ability raw Poligoni were compared high-fat diet fed rats this research. Total cholesterol (TC) low density lipoprotein-cholesterol (LDL-C) blood tissue all significantly higher model rats. However, triglyceride (TG) contents increased only tissue, not samples. diets considered...
We have tested an approach to identify putative cancer stem cells that involves measurement of the infrared absorption spectrum individual in aqueous environment, and their subsequent classification using multivariate data analysis techniques. Two primary esophageal cell lines were characterized: immortalized normal epithelial line, Het-1A, adenocarcinoma OE33. In addition, we also evaluated spheroids, reflecting stem-like populations, which derived from each parent line when grown...
Introduction. Raw and processed Notoginseng Radix Et Rhizome (NRR) have been widely used in treatment of metabolic syndromes related disease, including nonalcoholic fatty liver disease (NAFLD). This study was designed to investigate lipid regulation effects raw NRR steatotic L02 cell. Materials Methods. Steatotic cells were obtained after being cultured with 5% fat emulsion-10% FBS-RPMI 1640 medium for 48 h. Contents total cholesterol (TC), triglyceride (TG), free acid (FFA), high-density...
Objective: To investigate the relationship between gut microbiota structure and biochemical changes in patients with different types of nonalcoholic fatty liver disease (NAFLD), order to provide evidence for clinical diagnosis prevention NAFLD. Methods: Forty-eight NAFLD cases (NAFLD group), 40 type 2 diabetes mellitus combined group) 30 healthy (healthy were randomly enrolled, their body mass index, serum alanine aminotransferase, aspartate total bilirubin, cholesterol, triglyceride, high...
Abstract Background Panax notoginseng is a medicinally important Chinese herb with long history of cultivation and clinical application. The planting area mainly distributed in Wenshan Prefecture, where the quality safety P. have been threatened by high concentration arsenic (As) from soil. roles phosphate (Pi) transporters involved Pi acquisition arsenate (AsV) tolerance were still unclear this species. Results In study, two open reading frames (ORFs) PnPht1;1 PnPht1;2 separated cloned...