A5080781035- Glycosylation and Glycoproteins Research
- Microtubule and mitosis dynamics
- Genetic and Kidney Cyst Diseases
- Protist diversity and phylogeny
- Ubiquitin and proteasome pathways
- Galectins and Cancer Biology
- Nanoplatforms for cancer theranostics
- ATP Synthase and ATPases Research
- Pancreatic function and diabetes
- Advanced Nanomaterials in Catalysis
- RNA Research and Splicing
- Nanoparticle-Based Drug Delivery
- Protein Tyrosine Phosphatases
- Cancer Research and Treatments
- RNA modifications and cancer
- Bacteriophages and microbial interactions
- Innovative Teaching Methods
- Microbial Metabolic Engineering and Bioproduction
- Micro and Nano Robotics
- Cancer-related Molecular Pathways
- Genetic Neurodegenerative Diseases
- Mobile and Web Applications
- Pluripotent Stem Cells Research
- Cardiac Fibrosis and Remodeling
- Circular RNAs in diseases
University of Science and Technology of China
2024
University of Georgia
2020-2024
Texas A&M University
2017-2022
Renji Hospital
2022
Second Affiliated Hospital of Nanchang University
2022
Nanchang University
2022
Chinese Academy of Sciences
2016-2018
Shandong Institute of Automation
2016-2018
Capital Normal University
2011-2017
Nanfang Hospital
2011
The sensory organelle cilium is involved in sensing and transducing important signaling cascades almost all cells of our body. These ciliary-mediated pathways affect cellular homeostasis metabolisms profoundly. However, it completely unknown whether the metabolic state affects assembly cilia. This study to investigate how O-linked β-N-acetylglucosamine (O-GlcNAc), a sensor nutrients, regulates cilia length. Pharmacologic or genetic inhibition O-GlcNAcylation led longer cilia, vice versa....
The development of multifunctional nanoprobes for simultaneous targeted imaging, tumor boundary identification and photothermal therapy gastric cancer has become a great challenge.Herein, EGFR monoclonal antibody-conjugated Au@Ag nanorods decorated with DTNB (5,5'-Dithiobis-(2-nitrobenzoic acid)) (EGFR-Au@Ag NR nanotags) were prepared characterized.Their biocompatibility was analyzed by MTT assay.In vitro studies show that EGFR-Au@Ag nanotags own good capability targeting entering into...
Spinocerebellar ataxia type 10 (SCA10) is an autosomal dominant neurologic disorder caused by ATTCT expansion in the ATXN10 gene. Previous investigations have identified that depletion of Ataxin-10, gene product, leads to cellular apoptosis and cytokinesis failure. Herein we identify mitotic kinase Aurora B as Ataxin-10 interacting partner. interacts with phosphorylates at S12, evidenced vitro mass spectrometry analysis. Both endogenous S12-phosphorylated localizes midbody during...
The primary cilium plays critical roles in the homeostasis and development of neurons. Recent studies demonstrate that length is regulated by metabolic state cells, as dictated processes such glucose flux O-GlcNAcylation (OGN). study regulation during neuron development, however, has been an area left largely unexplored. This project aims to elucidate O-GlcNAc neuronal through its cilium. Here, we present findings suggesting OGN levels negatively regulate on differentiated cortical neurons...
Situs inversus totalis (SIT) is a rare internal laterality disorder characterized by the mirror arrangement of organs. Multiple gene mutations and maternal environmental factors are thought to cause this variation. It usually challenging perform laparoscopic surgery in these cases. Bladder diverticulum uncommon children, with an incidence 1.7%. We report 14-year-old male patient who was admitted our department because lower abdominal pain frequent urination. A series examinations confirmed...
Following 40 years of broad study, it has been established that O-GlcNAcylation (OGN) functions as a nutrient and stress sensor to regulate enzyme activities, protein localization, associations, degradation. OGN cycling is controlled by sole pair enzymes, O-GlcNAc transferase (OGT) O-GlcNAcase (OGA), over 8,000 targets in human cells have identified thus far. Most recently, emerging data suggests regulates translation mRNA selection during stress. However, the mechanisms which these...
The primary cilium plays critical roles in homeostasis and development of neurons. Recent studies demonstrate that cilia length is regulated by the metabolic state cells, as dictated processes such glucose flux O-GlcNAcylation (OGN). study regulation during neuron development, however, has been an area left largely unexplored. This project aims to elucidate O-GlcNAc neuronal through its cilium. Here, we present findings suggesting OGN levels negatively regulate on differentiated cortical...
Applications in biotechnology and synthetic biology often make use of soluble proteins, but there are many potential advantages anchoring enzymes to a stable substrate, including stability the possibility for substrate channeling. To avoid necessity protein purification chemical immobilization, has been growing interest bio-assembly protein-containing nanoparticles, exploiting self-assembly viral capsid proteins or other that form polyhedral structures. However, these nanoparticles limited...
Poverty is an eternal economic category, The National Bureau of Statistics specify poverty to statistical survey every year, how better express scale and extent using lots data a valuable problem study. In this paper, use has spatial dimension as the starting point, through database building design system framework combining business process achieve main module functions including management, subject visualization, thematic map browsing, monitoring analysis department information sharing....
In article number 1704634, Mei Tian, Jie Min Zhou, and co-workers present clearable nanoparticles for image-guided cancer therapy. CuS nanodots@mesoporous silica allow positron emission/photoacoustic bimodal imaging effective chemo-photothermal Irradiating the particles with a near-infrared laser forms ultrasmall fragments that exhibit high body clearance.
We describe an approach for using the flagella axoneme as basis biological self-assembling protein nanoarrays. The is insoluble core of eukaryotic flagellum or cilium. By attaching a interest to particular axonemal proteins, it possible exploit intraflagellar transport system incorporate those proteins into assembles. Using array confers several advantages, such high loading capacity compared other bioparticle systems; genetically programmed self-assembly without need any linking steps;...