A5100440628- Microtubule and mitosis dynamics
- Endoplasmic Reticulum Stress and Disease
- Peptidase Inhibition and Analysis
- Hippo pathway signaling and YAP/TAZ
- Autophagy in Disease and Therapy
- Cellular transport and secretion
- Breast Cancer Treatment Studies
- Inflammatory Biomarkers in Disease Prognosis
- Mitochondrial Function and Pathology
- Cellular Mechanics and Interactions
- Genetic Neurodegenerative Diseases
- Ubiquitin and proteasome pathways
- Thyroid Cancer Diagnosis and Treatment
- Head and Neck Cancer Studies
- Cancer Cells and Metastasis
- Atherosclerosis and Cardiovascular Diseases
- 14-3-3 protein interactions
- Caveolin-1 and cellular processes
- Effects of Radiation Exposure
- Mesenchymal stem cell research
- Ion Transport and Channel Regulation
- Heat shock proteins research
- Photosynthetic Processes and Mechanisms
- Esophageal Cancer Research and Treatment
- melanin and skin pigmentation
Nanjing Medical University
2009-2024
Jiangsu Province Hospital
2009-2024
Guangxi Medical University
2020-2024
Hebei Medical University
2023
Union Hospital
2021-2022
Huazhong University of Science and Technology
2013-2022
South China University of Technology
2022
The First Affiliated Hospital, Sun Yat-sen University
2019-2021
Sun Yat-sen University
2019-2021
Air Force Medical University
2020
Abstract Phosphatidylinositol phosphates (PIPs) and cholesterol are known to regulate the function of late endosomes lysosomes (LELs), ORP1L specifically localizes LELs. Here, we show in vitro that ORP1 is a PI(4,5)P 2 - or PI(3,4)P -dependent transporter, but cannot transport any PIPs. In cells, both required for efficient removal from Structures lipid-binding domain (ORP1-ORD) complex with display open conformations essential ORP function. /PI(3,4)P can facilitate ORP1-mediated by...
Abstract Hypoxic microenvironment deregulates metabolic homeostasis in cancer cells albeit the underlying mechanisms involved this process remain hitherto enigmatic. 14-3-3ζ/Yes-associated protein (YAP) axis plays a principal role malignant transformation and tumor development. Here, we report that hypoxia disassembles 14-3-3ζ from YAP thereby promotes nuclear localization mediated by ERK2, which directly binds to D-site of mitogen-activated kinase (MAPK) docking domain Leu98/100...
Spinocerebellar ataxia type 10 (SCA10) is an autosomal dominant neurologic disorder caused by ATTCT expansion in the ATXN10 gene. Previous investigations have identified that depletion of Ataxin-10, gene product, leads to cellular apoptosis and cytokinesis failure. Herein we identify mitotic kinase Aurora B as Ataxin-10 interacting partner. interacts with phosphorylates at S12, evidenced vitro mass spectrometry analysis. Both endogenous S12-phosphorylated localizes midbody during...
Thyroid cancer (TC) is the most common type of endocrine malignancy and its incidence increasing over years. Conventional surgery, radiotherapy chemotherapy are difficult to improve significant effects it due aggression metastasis poorly differentiated thyroid (PDTC) anaplastic (ATC), these regarded as malignant types TC. Glucose-regulated protein (GRP78) key molecule tumor growth, apoptosis metastasis. However, underlying mechanisms GRP78 in TC still require discussion. This study aimed...
To investigate the impact of effective radiation dose to immune cells (EDIC) and gross tumor volume (GTV) on lymphopenia survival in patients with locally advanced esophageal squamous cell carcinoma (LAESCC). Between January 2013 December 2020, 272 LAESCC were treated definitive radiotherapy two institutions. Based doses lungs, heart, body region scanned, EDIC was calculated as an equal uniform total blood considering flow fraction effect. The plan used calculate GTVs. Lymphopenia graded...
Autophagy and glycolysis are two catabolic processes that manipulate pancreatic ductal adenocarcinoma (PDAC) development in response to hypoxia sensing, yet the underlying mechanism of how they interlinked remain elusive.Methods: The functional roles Unc-51 like kinase 1 2 (ULK1/2) pyruvate M2 (PKM2) transcription under were assessed by chromatin immunoprecipitation, luciferase reporter, glucose consumption lactate production assay.Co-immunoprecipitation, cellular ubiquitination,...
To compare the cosmetic efficacy of transplantation follicles with intact and non-intact hair bulbs in treatment for vitiligo.The single-hair follicle units un-intact were transplanted into skin vitiligo. The diameters regrowing shafts repigmentation implanted detected analyzed by dermatoscopy (Beining BN-PFMF Skin Hair Visualizer).The survival rates 60.00% 50.62%, respectively. average two groups 92.83 ± 7.26 µm vs 55.86 2.64 (p < .05), 2.62 0.13 mm 2.63 0.17 > respectively.Single was an...
Hepatocytes exhibit a multi-polarized state under the in vivo physiological environment, however, human embryonic stem cell-derived hepatocytes (hEHs) rarely polarity features two-dimensional (2D) condition. Thus, we hypothesized whether polarized differentiation might enhance maturity and liver function of hEHs. In this study, obtained hEHs (phEHs) by using 2D conjunct with employing transwell-based culture. Our results showed that phEHs directionally secreted albumin, urea bile acids,...
This study aimed to develop a combined ultrasound (US)-pathology model predict the axillary status more accurately after NST in breast cancer.
Abstract Background: Thyroid cancer (TC) is the most common type of endocrine malignancy tumor and incidence it increasing over years. Conventional surgery, radiotherapy chemotherapy are difficult to improve significant effects due aggression metastasis poorly differentiated thyroid (PDTC) anaplastic (ATC), which regarded as malignant TC. Glucose-regulated protein (GRP78) key molecule growth, apoptosis metastasis. However, underlying mechanisms GRP78 on TC still require discussion. This...
Abstract Background: Thyroid cancer (TC) is the most common type of endocrine malignancy and its incidence increasing over years. Conventional surgery, radiotherapy chemotherapy are difficult to improve significant effects it due aggression metastasis poorly differentiated thyroid (PDTC) anaplastic (ATC), these regarded as malignant types TC. Glucose-regulated protein (GRP78) key molecule tumor growth, apoptosis metastasis. However, underlying mechanisms GRP78 in TC still require discussion....