A5013666844- Neuroinflammation and Neurodegeneration Mechanisms
- Neurogenesis and neuroplasticity mechanisms
- Barrier Structure and Function Studies
- Acute Ischemic Stroke Management
- Neurological Disease Mechanisms and Treatments
- Nerve injury and regeneration
- Nicotinic Acetylcholine Receptors Study
- Intracerebral and Subarachnoid Hemorrhage Research
- Neuroscience and Neuropharmacology Research
- Autophagy in Disease and Therapy
- Tryptophan and brain disorders
- Alzheimer's disease research and treatments
- Memory and Neural Mechanisms
- Liver Disease Diagnosis and Treatment
- Parkinson's Disease Mechanisms and Treatments
- Mitochondrial Function and Pathology
- Receptor Mechanisms and Signaling
- Caveolin-1 and cellular processes
- Hepatitis B Virus Studies
- Liver Disease and Transplantation
- Piperaceae Chemical and Biological Studies
- Nuclear Receptors and Signaling
- Congenital gastrointestinal and neural anomalies
- Cytokine Signaling Pathways and Interactions
- Calcium signaling and nucleotide metabolism
Soochow University
2016-2025
Second Affiliated Hospital of Soochow University
2016-2025
Soochow University
2025
Shanghai Institutes for Biological Sciences
2019
Yantai University
2017-2018
Qilu Hospital of Shandong University
2015-2017
Chinese Academy of Sciences
2017
Increase of blood brain barrier (BBB) permeability after acute ischemia stroke is a predictor to intracerebral hemorrhage transformation for tissue plasminogen activator (tPA) thrombolysis and post-endovascular treatment. Previous studies showed that 2-h induced damage BBB integrity matrix metalloproteinase-2 (MMP-2) made major contribution this disruption. A recent study blocking β2-adrenergic receptor (β2-AR) alleviated ischemia-induced injury by reducing hypoxia-inducible factor-1 alpha...
Blood–brain barrier (BBB) dysfunction is considered to be an early event in the pathogenesis of a variety neurological diseases old patients, and this could occur people even when facing common stress. However, mechanism remains defined. In study, we tested hypothesis that decreased melatonin levels may account for BBB disruption mice challenged with lipopolysaccharide (LPS), which mimicked stress sepsis. Mice (24–28 months age) received (10 mg kg−1 day−1, intraperitoneally, i.p.) or saline...
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by memory impairments, which has no effective therapy. Stem cell transplantation shows great potential in the therapy of various disease. However, application stem neurological disorders, especially ones with long-term course such as AD, limited delivery approach due to presence brain blood barrier. So far, most commonly used disorders cells preclinical and clinical studies are intracranial injection intrathecal...
Altered visceral sensation is common in irritable bowel syndrome (IBS) and nerve growth factor (NGF) participates pain development. Sodium butyrate (NaB) could induce colonic hypersensitivity via peripheral up-regulation of NGF animals. Enteric glial cells (EGCs) appear to be an important source NGF. Whether increased EGC-derived still unknown.CRL-2690 were used for transcriptome analyses after treatment. Rats received enemas hypersensitivity. Colorectal distention test was performed assess...
Disruption of the blood brain barrier (BBB) within thrombolytic time window is an antecedent event to intracerebral hemorrhage in ischemic stroke. Our recent studies showed that 2-h cerebral ischemia induced BBB damage non-infarcted area and secreted matrix metalloproteinase-2 (MMP-2) accounted for this disruption. However, factors affect MMP-2 secretion regulate remains unknown. Since hypoxia-inducible factor-1 alpha (HIF-1α) was discovered as a mater regulator hypoxia, we sought...
<title>Abstract</title> Aging drives cognitive decline in the adult brain with unclear mechanisms. Previously, oligodendrocyte precursor cells (OPCs), source of myelin-forming central nervous system, have been linked to aging by their compromised differentiation and regeneration capability. Whether a myelination-independent function OPCs is involved remains unknown. In this study, we herein report role exaggerating via suppressing neuronal plasticity. Our results demonstrate that...
Thrombolysis with tissue plasminogen activator (tPA) increases matrix metalloproteinase-9 (MMP-9) activity in the ischemic brain, which exacerbates blood-brain barrier injury and risk of symptomatic cerebral hemorrhage. The mechanism through tPA enhances MMP-9 is not well understood. Here we report an important role caveolin-1 mediating tPA-induced synthesis. Brain microvascular endothelial cell line bEnd3 cells were incubated 5 or 20 μg/ml for 24 hrs before analyzing levels conditioned...
Dl-3-N-butylphthalide (NBP) has been used in clinic to treat acute ischemic stroke, however, it not approved stroke patients during the late stage of since effect on functional recovery is confirmed and mechanism clear. In this study, using mice MCAO model, we aim explore two-week NBP treatment after as well underlying mechanism. Our results showed that attenuated improved neurological scores, enhanced performance adhersive remove test, integrity white matter 60-min ischemia 14-day...
Fear memory is a fundamental capability for animals and humans to survive. Its impairment results in the disability avoid danger. When reactivated, reconsolidation process, which can be disrupted by various stimuli, including inflammation, required become permanent. Nicotine has been shown improve cognitive deficits induced inflammation other stimuli. Therefore, present study, we investigated effect of nicotine on lipopolysaccharide (LPS)-induced fear underlying mechanism.Step-through...
Abstract Background Systemic inflammation in which lipopolysaccharide (LPS) is released into circulation can cause cognitive dysfunction and we have previously shown that LPS impaired working memory (WM) refers to the ability guide incoming behavior by retrieving recently acquired information. However, mechanism not very clear, currently, there no approved strategy improve inflammation‐induced WM deficit. Notably, epidemiological studies demonstrated a lower occurrence rate of...