A5100385995- Vestibular and auditory disorders
- Neurological Disease Mechanisms and Treatments
- EEG and Brain-Computer Interfaces
- Neurological disorders and treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Migraine and Headache Studies
- Barrier Structure and Function Studies
- Dysphagia Assessment and Management
- Acute Ischemic Stroke Management
- Neurological Disorders and Treatments
- Cancer-related molecular mechanisms research
- Ginkgo biloba and Cashew Applications
- Hearing, Cochlea, Tinnitus, Genetics
- Genetic Neurodegenerative Diseases
- Functional Brain Connectivity Studies
- Gut microbiota and health
- Immune Response and Inflammation
- Epigenetics and DNA Methylation
- Multilingual Education and Policy
- Ion channel regulation and function
- Cardiovascular Health and Disease Prevention
- Antimicrobial Peptides and Activities
- Intracerebral and Subarachnoid Hemorrhage Research
- Inflammasome and immune disorders
- Alzheimer's disease research and treatments
Jiaxing University
2012-2024
Sun Yat-sen University
2019-2024
Fudan University
2024
The First Affiliated Hospital, Sun Yat-sen University
2024
Zhongshan Hospital
2024
Binzhou University
2023
Binzhou Medical University
2023
Yuhuangding Hospital
2023
Qingdao University
2023
Fuzhou Maternity and Child Health Care Hospital
2023
The present study was designed to investigate the role of β-amyloid (Aβ1-42 ) in inducing neuronal pyroptosis and its mechanism. Mice cortical neurons (MCNs) were used this study, LPS + Nigericin induce MCNs (positive control group), Aβ1-42 interfere with MCNs. In addition, propidium iodide (PI) staining examine cell permeability, lactate dehydrogenase (LDH) release assay employed detect cytotoxicity, immunofluorescence (IF) expression level key protein GSDMD, Western blot performed levels...
Dl-3-N-butylphthalide (NBP) has been used in clinic to treat acute ischemic stroke, however, it not approved stroke patients during the late stage of since effect on functional recovery is confirmed and mechanism clear. In this study, using mice MCAO model, we aim explore two-week NBP treatment after as well underlying mechanism. Our results showed that attenuated improved neurological scores, enhanced performance adhersive remove test, integrity white matter 60-min ischemia 14-day...
ABSTRACT Objectives: The study aimed to promote nurses’ compliance with best practices for dysphagia screening in patients stroke. Introduction: Dysphagia can significantly increase the risk of complications, especially aspiration pneumonia, leading increased disability, death, and high medical expenses. reduce is recommended as a crucial step management; however, not all stroke undergo neurology ward. Methods: JBI Evidence Implementation Framework was used this study. A baseline audit...
Parkinson's disease (PD) is a neurodegenerative disease, and the role of neuroinflammation in pathogenesis progression PD has been confirmed. The polysaccharides triterpenoids antrodia camphorata (a polyporous fungus) harbor diverse powerful pharmacological effects. In this study, 6-hydroxydopamine was used to construct mouse model. After polysaccharide (ACP) intervention, neurobehavioral changes were detected, neurotransmitter striatum determined by high-performance liquid chromatography,...
Background and Purpose: We aimed to investigate the effect of Ginkgolide® treatment on neurological function in patients receiving intravenous (IV) recombinant tissue plasminogen activator (rt-PA). Methods: This cluster randomized controlled trial included acute ischemic stroke 24 centers intervention or control group within first h after IV rt-PA therapy (IVT). Clinical outcome at 90 days was assessed with modified Rankin Scale (mRS) score dichotomized into good (0-2) poor (3-6)....
Background Tourette syndrome (TS) is associated with immunological dysfunction. The DA system closely related to TS development, or behavioral stereotypes. Previous evidence suggested that hyper-M1-polarized microglia may exist in the brains of individuals. However, role and their interaction dopaminergic neurons unclear. In this study, we applied iminodipropionitrile (IDPN) establish a model focused on inflammatory injury striatal microglia-dopaminergic-neuron crosstalk. Methods Male...
The aim of the present study was to observe effects and mechianisms melatonin on proliferation apoptosis lung cancer (LC) cells. A549 cells were treated with a concentration gradient (0–100 μM) for 24 hours, cell viability detected by XTT ((2,3-Bis-(2-methoxy-4-nitro-5-sulfophenyl) −2H-tetrazolium-5-carboxanilide)) colorimetry. Melatonin 50 μM selected interact LC ten days, then colony formation assay used detect TUNEL (Terminal-deoxynucleoitidyl Transferase Mediated Nick End Labeling)...
Abstract The present study was designed to investigate the mechanism of myeloid differentiation protein 2 (MD2) on intestinal mucosa destruction in mice with chronic colitis. Briefly, a colitis mouse model established by administration dextran sulfate sodium (DSS) transgenic MD2 overexpression (Transgenic, MD2‐Tg) and C57BL/6 wild‐type (MD2‐WT). In addition, Caco‐2 cells were cultured form monolayer cell vitro. small interfering RNA utilized silence gene cells, tumor necrosis factor‐α...
Investigation of the protective effect chrysanthemum extract in ischemic strokes patients is among challenging issues with traditional hospital system general and smart technology-based hospitals particular. In this study, we have evaluated on stroke by detecting severity stroke, neuronal indexes, oxidative stress biomarkers. For purpose, forty-six were randomly divided into control group (n = 30) 30). The received standard treatment, was treated 400 mg/day (200 mg/day, twice/day) basis...
Mastitis is a common disease for mammals all around the world. Figuring out why mastitis mainly occurs parturition may be helpful dealing with disease. Lipolytic activity and oxidative stress take place parturition, which leads to alteration in fatty acids profile proinflammatory cytokine expression. Thus, aim of present study was further our understanding about high incidence by comparison plasma acid mammary inflammation indicators at different reproductive stages. A total 47 female rats...
Dystrophia myotonica (DM) type 1 is an autosomal dominant disorder, caused by a trinucleotide CTG repeat expansion in the 3' untranslated region of dystrophia protein kinase (DMPK) gene (chromosome 19q13.3). The disorder affects different organ systems, including skeletal muscles, ocular lens, lungs, heart and gastrointestinal tract, as well endocrine central nervous systems. muscles are most frequently involved, whereby manifests myotonia, muscle weakness amyotrophy. However, DM presenting...
Objective To observe the effect of combining acupuncture with transcranial magnetic stimulation (rTMS) in treating post-stroke dysphagia oral stage. Methods Thirty-nine stroke survivors stage were randomly divided into an experimental group (n=19) and a control (n=20). Both groups given basic supportive treatment rehabilitation, including rTMS for 4 weeks. The additionally received acupuncture. Modified barium swallowing impairment profiles (MBSImPs) transit time (OTT) used to assess...
Patients with acute isolated vertigo have a high risk for developing cerebral infarction (CI). Risk stratification in patients is critical early treatment and preventative therapy. In the present study, we aim to characterize diagnostic value of serum adiponectin (APN) combined ABCD2 scoring determining risk.Patients admitted emergency room were recruited. Diagnosis was performed using diffusion-weighted MRI (DWI-MRI) T2WI T2Flair imaging. Blood collected analysis APN levels enzyme-linked...
Semont maneuver was performed in 97 patients with benign paroxysmal positional vertigo involving the posterior semicircular canal. Among successful 69 cases and failed 28 cases. There were three nystagmus patterns during third position of maneuver: orthotropic (n=45), no (n=42) reversed (n=10); effective rates groups 93%, 64% 0%, respectively (P 0.05). Key words: Vertigo, positional; Nystagmus, pathologic
To investigate the abnormal whole brain functional connectivity patterns in patients with VM by a fully data-driven resting-state methods without any hypothesis. Our findings indicated that amplitude of low-frequency fluctuation (ALFF) and abnormalities these regions may be associated impairments pain information processing modulation, transmitting multisensory integration VM.
Hypothesis The stress hormone cortisol affects aminoglycoside-induced ototoxicity. Background widespread use of aminoglycosides is a prevalent cause sensorineural hearing loss. Patients receiving usually have elevated levels circulating hormones due to disease or physiological stress; however, whether the impacts aminoglycoside-mediated injury cochlear hair cells has not been fully investigated. Methods House Ear Institute-Organ Corti 1 (HEI-OC1) with without pretreatment were exposed...
Objective To observe the effects of different environmental intervention on learning-memory ability and choline acetyltransferase (ChAT) expression around infarct in rats with unilateral local cerebral infarction. Methods SD were subjected to electric coagulation MCA then assigned randomly ①control group(5 each group housed a standard cage), ②learn training group(housed maze ③enriched environment enriched cage). 24 days later, trained by water maze, killed for immunohistochemistry...
Objective To evaluate the diagnostic value of sympathetic skin response(SSR)in patients with vestibular vertigo.Methods SSR tests were performed on 1 20 acute system vertigo,including 70 cases central vertigo and 50 eases peripherM vertigo.60 healthy subjects also examined to serve as controls.Results In those vertigo,the abnormality rate in results was 87.1%(61/70).SSR latency longer its amplitude wag lower than peripheral heMthy controls.In 18.0%(9/50),but average not significantly...
Objective To observe the effect of quercetin (Que) on neurological behavior, cell apoptosis and apoptosis-related protein expression in hippocampus after global cerebral ischemia/reperfusion (I/R) injury. Exploring mechanism quercetin-induced neuroprotective against I/R injury. Methods Seventy two Male SD rats were randomly divided into 4 groups (n=18): sham+vehicle group (S group), I/R+vehicle (I/R I/R+Que 5 mg·kg-1·d-1 (Q5 group) 10 (Q10 group). The ischemia reperfusion model was...