A5033549570- Peripheral Neuropathies and Disorders
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Cerebral Venous Sinus Thrombosis
- Autoimmune Neurological Disorders and Treatments
- Venous Thromboembolism Diagnosis and Management
- Neurological Disease Mechanisms and Treatments
- Acute Ischemic Stroke Management
- Neurological Disorders and Treatments
- Genetic Neurodegenerative Diseases
- Blood Coagulation and Thrombosis Mechanisms
- Folate and B Vitamins Research
- Mitochondrial Function and Pathology
- Treatment of Major Depression
- Cerebrovascular and genetic disorders
- Heme Oxygenase-1 and Carbon Monoxide
- Cellular transport and secretion
- Long-Term Effects of COVID-19
- Neuroinflammation and Neurodegeneration Mechanisms
- Cardiac Health and Mental Health
- Multiple Sclerosis Research Studies
- Dementia and Cognitive Impairment Research
- Neonatal Health and Biochemistry
- Perfectionism, Procrastination, Anxiety Studies
- Tryptophan and brain disorders
- Cancer-related molecular mechanisms research
First Hospital of Jilin University
2015-2025
Jilin University
2015-2025
Background Ischemic stroke (IS) is a cerebrovascular disease caused by various factors, and its etiology remains inadequately understood. The role of immune system dysfunction in IS has been increasingly recognized. Our objective was to evaluate whether circulating cells causally impact risk. Methods We conducted two-sample Mendelian randomization analyses the causal effects 731 cell traits on IS, utilizing publicly available genome-wide association studies (GWAS) summary statistics for as...
The long non-coding RNA, urothelial carcinoma associated 1 (UCA1) has been demonstrated to play important roles in various types of cancers.This study investigated the functional role UCA1 glioma and explored underlying molecular mechanisms.UCA1 was found be highly up-regulated cells, knock-down inhibited cell growth, invasion migration, also induced apoptosis cells.On other hand, overexpression promoted proliferation, migration cells.Knockdown suppressed activity Wnt/β-catenin signaling,...
<b><i>Objective:</i></b> This study aims to retrospectively clinical characteristics, diagnosis, treatment and follow-up visits in patients with anti-leucine-rich glioma inactivated-1 (LGI1) limbic encephalitis (LE) for prompting the early diagnosis efficacious of this disease. <b><i>Methods:</i></b> Four anti-LGI1 LE were hospitalized Department Neurology at First Hospital Jilin University. Data from their manifestations, diagnoses, treatments...
Cerebrovascular remodeling is the most common cause of hypertension and stroke. Ubiquitin E3 ligase RING finger protein 34 (RNF34) suggested to be associated with development multiple neurological diseases. However, importance RNF34 in cerebrovascular poorly understood. Herein, we used mice a global knockout as well floxed delete endothelial cells smooth muscle (SMCs). Our results showed that substantially promoted angiotensin II (AngII)-induced middle cerebral artery (MCA) remodeling,...
Primary angiitis of the central nervous system (PACNS) is a rare, but severe vascular disease. The present study reports case 42-year-old male who developed PACNS. Magnetic resonance imaging (MRI) scans initially led to misleading diagnosis malignant glioma, and surgery was performed. mass resected, pathological examination confirmed cerebral vasculitis. Single therapy with high doses steroid did not improve patient's condition, while subsequent lesion appeared on opposite side one year...
Herpes simplex virus (HSV) is the most common cause of acute viral encephalitis. Acute retinal necrosis (ARN) a rapidly progressing and potentially blinding eye disease that may be induced by HSV. The present case study reports very rare patient with herpes encephalitis (HSE) combined (ARN). A 47-year-old woman was admitted to hospital persistent high fever somnolence for 5 days. Magnetic resonance imaging showed abnormal signals in right medial temporal lobes, HSV-1 identified serum...
Neuromyelitis optica (NMO) appears to be a severe inflammatory demyelinating disease occurring in the central nervous system. Furthermore, Fc receptor-like 3 (FCRL3) gene was previously found susceptible for certain diseases (such as multiple sclerosis). The present study, therefore, aimed explore possible association of FCRL3 polymorphisms with susceptibility NMO Chinese Han population. Seven single nucleotide (SNPs) were, respectively, genotyped 132 patients and 264 healthy controls via...
Multiple sclerosis (MS) is easily detected by routine magnetic resonance imaging (MRI). However, it not possible to detect early or occult lesions in MS MRI, and this may explain the inconsistency between severity of found MRI degree clinical disability patients with MS. The present study included 10 relapsing-remitting healthy volunteers. Each patient underwent 3.0 T diffusion tensor (DTI), tractography (DTT). Optic nerve optic radiation were analyzed DTI DTT. fractional anisotropy (FA),...