A5100331618- Neuroinflammation and Neurodegeneration Mechanisms
- Neurological Disease Mechanisms and Treatments
- Barrier Structure and Function Studies
- Tryptophan and brain disorders
- Gut microbiota and health
- Immune cells in cancer
- Neurological Disorders and Treatments
- Advanced Nanomaterials in Catalysis
- Adolescent and Pediatric Healthcare
- Alzheimer's disease research and treatments
- Biochemical Analysis and Sensing Techniques
- Regulation of Appetite and Obesity
- Neonatal and fetal brain pathology
- Genetics and Neurodevelopmental Disorders
- Ferroptosis and cancer prognosis
- Extracellular vesicles in disease
- Intracerebral and Subarachnoid Hemorrhage Research
- Intraoperative Neuromonitoring and Anesthetic Effects
- Neuroblastoma Research and Treatments
- Aortic Disease and Treatment Approaches
- Anesthesia and Neurotoxicity Research
- Inflammatory mediators and NSAID effects
- Axon Guidance and Neuronal Signaling
- Antimicrobial Peptides and Activities
- Nuclear Receptors and Signaling
Fudan University
2017-2025
Guangzhou University of Chinese Medicine
2023-2024
Shanghai Children's Medical Center
2020-2024
Binzhou University
2023
Binzhou Medical University
2023
Yuhuangding Hospital
2023
Qingdao University
2023
Hubei University of Medicine
2023
Zhujiang Hospital
2022
Sanofi (United States)
2022
Iron dysregulation has been implicated in multiple neurodegenerative diseases, including Parkinson's disease (PD). Iron-loaded microglia are frequently found affected brain regions, but how iron accumulation influences physiology and contributes to neurodegeneration is poorly understood. Here we show that human induced pluripotent stem cell-derived grown a tri-culture system highly responsive susceptible ferroptosis, an iron-dependent form of cell death. Furthermore, overload causes marked...
Thrombolysis has been a standard treatment for ischemic stroke. However, only 2-7% patients benefit from it because the thrombolytic agent to be injected within 4.5 h after onset of symptoms avoid increasing risk intracerebral hemorrhage. As clinically approved neuroprotective drug, edaravone (EDV) rescues brain tissues by eradicating over-produced reactive oxygen species (ROS) without limitation therapeutic time-window. EDV's short circulation half-life and inadequate cerebral uptake...
Abstract Previous observational studies have suggested an association between tryptophan (TRP)–kynurenine (KYN) pathway and inflammatory bowel disease (IBD). However, whether there is a causal relationship among them remains unclear. Therefore, two-sample Mendelian randomization (MR) study was conducted to explore the potential effects of crucial metabolites in TRP–KYN on IBD its subtypes. Using summary data from genome-wide studies, MR employed evaluate genetic associations TRP KYN as...
Cardiac fibrosis under chronic pressure overload is an end-stage adverse remodeling of heart. However, current heart failure treatments barely focus on anti-fibrosis and the effects are limited. We aimed to seek for a cardiac abundant specific piRNA, exploring its underlying mechanism therapeutic potential. Whole transcriptome sequencing following verification experiments identified highly upregulated piRNA (piRNA-000691) in transverse aortic constriction (TAC) mice, TAC pig, human samples,...
Subarachnoid hemorrhage (SAH) is considered a devastating disease, leaving survivors with lifelong neurological impairment. With increased knowledge that regulatory T cells (Tregs) provide protection against stroke, novel agents which could expand Treg populations have been assessed in terms of the potential clinical neuroprotection effect. Using rat SAH model, we investigated number variation Tregs induced by and protective effect low-dose interleukin-2 (IL-2) treatment on model. We...
Depression is a global mental disorder disease and greatly threatened human health stress considered to be one of the important factors that lead depression. In this study, we used newly developed iTRAQ labeling high performance liquid chromatography (HPLC) mass spectrum united analysis technology obtained 2176 accurate proteins. Successively, GO IPA software analyze 98 differentially expressed proteins liver in depression rats due chronic restraint stress, showing map proteomics from...
The sex-peptide receptor (SPR) acts in Drosophila females to detect male (SP) and trigger changes female behaviour. Further study on SPR its ligand family from different taxa will not only provide insight into ligand–receptor coevolution but also facilitate finding new approaches for pest control. Our previous studies the tobacco cutworm Spodoptera litura (Fabricius, 1775) showed that mating usually results marked behaviour determined factors accessory gland (MAG) secretions play a key role...
Although various surgical techniques have been reported for aortic arch reconstruction proximal and distal transverse (PDTA) hypoplasia, no consensus has reached on a option initial reconstruction. This study was undertaken to review options PDTA hypoplasia in Chinese infants.A retrospective of 121 infants who underwent the arches between 2010 2020 performed. Freedom from recoarctation analyzed using Kaplan-Meier analysis. Univariate multivariable Cox regression analyses were performed...
At-home rehabilitation for post-stroke patients presents significant challenges, as continuous, personalized care is often limited outside clinical settings. Additionally, the absence of comprehensive solutions addressing diverse needs in home environments complicates recovery efforts. Here, we introduce a smart platform that integrates wearable sensors, ambient monitoring, and large language model (LLM)-powered assistance to provide seamless health monitoring intelligent support. The system...
Abstract Previous observational studies have suggested an association between tryptophan (TRP) -kynurenine (KYN) pathway and inflammatory bowel disease (IBD). However, whether there is a causal relationship among them remains unclear. Therefore, two-sample Mendelian randomization (MR) study was conducted to explore the potential effects of crucial metabolites in TRP-KYN on IBD its subtypes. Using summary data from genome-wide (GWASs), MR employed evaluate genetic associations TRP or KYN as...
Hypothesis The stress hormone cortisol affects aminoglycoside-induced ototoxicity. Background widespread use of aminoglycosides is a prevalent cause sensorineural hearing loss. Patients receiving usually have elevated levels circulating hormones due to disease or physiological stress; however, whether the impacts aminoglycoside-mediated injury cochlear hair cells has not been fully investigated. Methods House Ear Institute-Organ Corti 1 (HEI-OC1) with without pretreatment were exposed...
Although the clinical manifestations of membranous supravalvular aortic stenosis (SVAS) are distinctive, its diagnosis remains challenging. Failure to initiate surgical treatment in a timely manner greatly increases risk sudden cardiac death. We report case SVAS, detailing presentation and imaging manifestations. The authors declare that they have no competing interests. My data is available.