A5075343449- Cardiac Arrest and Resuscitation
- Traumatic Brain Injury and Neurovascular Disturbances
- Cardiac Ischemia and Reperfusion
- Anesthesia and Sedative Agents
- Mechanical Circulatory Support Devices
- Anesthesia and Neurotoxicity Research
- Anesthesia and Pain Management
- Cardiac, Anesthesia and Surgical Outcomes
- Thermal Regulation in Medicine
- Diet and metabolism studies
- Neurological Disorders and Treatments
- Transplantation: Methods and Outcomes
- Hemodynamic Monitoring and Therapy
- Renal function and acid-base balance
- Heart Rate Variability and Autonomic Control
- Muscle metabolism and nutrition
- Cardiac and Coronary Surgery Techniques
- Clinical Nutrition and Gastroenterology
- Organ Transplantation Techniques and Outcomes
- Respiratory Support and Mechanisms
- Intensive Care Unit Cognitive Disorders
- Traumatic Brain Injury Research
- Cardiac Valve Diseases and Treatments
- Cardiac Structural Anomalies and Repair
- Spinal Cord Injury Research
Uppsala University
2010-2024
Uppsala University Hospital
2008-2023
Sahlgrenska University Hospital
2000-2022
Karolinska Institutet
1984-2021
Umeå University
2017-2018
Eskilstuna Municipality
2010-2012
Karolinska University Hospital
1983-2010
Swedish Research Council
1997-2010
Memorial Foundation
2010
University of Gothenburg
1993-2008
The potential to be successfully resuscitation from severe traumatic hemorrhagic shock is not only limited by the "golden 1 hr", but also "brass (or platinum) 10 mins" for combat casualties and civilian trauma victims with exsanguination. One research challenge determine how best prevent cardiac arrest during hemorrhage, before control of bleeding possible. Another critical limits of, optimal treatments for, protracted hypotension, in order "delayed" multiple organ failure after hemostasis...
Abstract. Red cells depleted of buffy coat and more than 90% the plasma were suspended stored in a medium composed sodium chloride, adenine, glucose man‐nitol (SAGM). The 24‐hour posttransfusion survival 51 Cr‐labeled red was 83.5 ± 5.3% (n = 4) after storage for 35 days 77.4 4.7%o 6) 42 days. No abnormal vivo hemolysis occurred as judged from haptoglobin consumption studies. body temperature elevation found at continuous pertrans‐fusion recordings. frequency febrile or urticaria1...
The pharmacokinetics of physostigmine after intravenous, intramuscular or subcutaneous administration as well its arousal effect anaesthesia have been studied in surgical patients the early postoperative period. After intravenous had a very rapid plasma elimination with clearance ranging from 47 to 163 1/h mean s. d. 92.5 37.7 1/h. volume distribution was 46.5 19.2 1, while and half‐lives were 2.3 22 min, respectively. A fraction dose probably hydrolyzed blood since half‐life vitro...
Cell therapy has been shown to be a key clinical therapeutic option for central nervous system diseases or damage. Standardization of cell procedures is an important task professional associations devoted therapy. The Chinese Branch the International Association Neurorestoratology (IANR) completed first set guidelines governing application neurorestoration in 2011. IANR and (CANR) collaborated propose current version "Clinical Therapy Guidelines Neurorestoration (IANR/CANR 2017)". council...
In a porcine model of cardiopulmonary resuscitation (CPR), we investigated changes in the plasma levels 8‐iso‐PGF 2α , marker for oxidative injury, and 15‐keto‐dihydro‐PGF an inflammatory response indicator during post‐resuscitation period after cardiac arrest. Twelve piglets were subjected to either 2 or 5 min (VF2 VF5 group) ventricular fibrillation (VF) followed by closed‐chest CPR. Six without arrest used as controls. group, jugular bulb (draining brain) increased four‐fold. Jugular...
A double‐blind clinical trial of the analgesic and antisedative effects physostigmine was carried out on surgical patients (n = 60) during first hours postoperatively. Pethidine placebo were included for comparison in study. The degree pain sedation estimated when patient demanded analgesics immediately before administration test drug. dosage administered i.v. was: salicylate 2 mg, placebo=saline, or pethidine chloride 50 mg. After this, same parameters recorded at regular intervals. In...
To investigate the effects of cardiac arrest and reperfusion syndrome on blood-brain barrier permeability evaluate whether methylene blue counteracts disruption in a pig model controlled cardiopulmonary resuscitation.Randomized, prospective, laboratory animal study.University-affiliated research laboratory.Forty-five piglets.Forty-five anesthetized piglets were subjected to alone or 12-min followed by 8 mins resuscitation. The first group (n = 16) was used disruptions after untreated...
Pulmonary hypertension (PH), defined as a pulmonary vascular resistance (PVR) >2.5 Wood units (WU) and (or) transpulmonary gradient (TPG) >12 mmHg, is an established risk factor for mortality in heart transplantation. Elevated PVR transplant candidates can be reduced using left ventricular assist device (LVAD), LVAD proposed to the treatment of choice with PH. We analyzed effect on pretransplant therapy patients PH compared posttransplant outcome matched controls. Long-term survival was...
The role of nitric oxide (NO) in spinal cord injury (SCI)-induced motor dysfunction, breakdown the blood-spinal barrier (BSCB), edema formation, and cell was examined using a pharmacological approach. We used three types synthase (NOS) inhibitors: nonselective blocker, L-NAME; an irreversible inhibitor all isoforms NOS, L-NMMA; long-term competitive neuronal NOS with equal potency to inhibit endothelial L-NNA. compounds were administered once daily separate groups rats for 7 days. On 8th...
Methylene blue (MB), a free-radical scavenger inhibiting the production and actions of nitric oxide, may counteract excessive vasodilatation induced by oxide during cardiac arrest. Effects MB in arrest cardiopulmonary resuscitation were investigated.Randomized, prospective, laboratory animal study.University research laboratory.A total 63 piglets both sexes.A pig model extended (12 mins untreated 8 resuscitation) was employed to assess addition or no hypertonic saline-dextran solution. These...
A moderate elevation of blood sugar and a reduction glucose tolerance occur in association with surgical trauma. This may be due to an increased release from the liver or reduced peripheral uptake glucose, both. The present study was undertaken investigate exchanges energy substrates. Twenty‐six patients undergoing cholecystectomy underwent turnover studies on blood‐borne substrates leg before, during, immediately after surgery. Measurements flow femoral arteriovenous differences oxygen,...
Background and purpose Physical therapy is recommended for the treatment of H untington's disease, but reliable studies investigating its efficacy are almost non‐existent. This may in part be due to lack suitable outcome measures. Therefore, we investigated applicability novel quantitative objective assessments motor dysfunction evaluation physical interventions aimed at improving gait posture. Methods Twelve patients with untington disease received a predefined twice‐weekly intervention...
We report the first clinical application of a new anaesthetic agent‐saving device. The principles heat–moisture exchanger have been further developed to create device that reduces inhalational agent consumption. Sixteen patients were randomly allocated receive isoflurane through either vaporiser or A coaxial Mapleson D system (Bain) was used in both groups. standard ventilatory setting used, aiming for normocapnia. Mean (SD) consumption 24.5 (2.8) ml.MAC‐hour −1 with vaporiser, compared 15.2...
Objective To evaluate the blood flow and perfusion pressure differences observed during open- vs. closed-chest cardiopulmonary resuscitation (CPR), including effects of epinephrine sodium bicarbonate administration. Design Prospective, randomized, controlled trial. Setting Experimental animal laboratory in a university hospital. Subjects A total 35 anesthetized piglets. Interventions After tracheostomy insertion arterial, right atrial, pulmonary arterial catheters, thoracotomy was performed...
Background: Due to a few reports of cerebral dysfunction in connection with isoflurane‐induced hypotension and concomitant hypocapnia, positron emission tomography (PET) was used measure oxygenation blood flow during similar conditions isoflurane or propofol. Methods: The short‐lived radionuclide 15 O for measurement cerebralmetabolic rate oxygen (CMRO 2 ), (CBF) extraction ratio (OER) regionally rhesus monkeys normotensive/normocapnic hypotensive/hypocapnic conditions, mean arterial...