A5014526047- Bone health and osteoporosis research
- Bone and Joint Diseases
- Bone health and treatments
- Spinal Cord Injury Research
- Stroke Rehabilitation and Recovery
- Hemoglobinopathies and Related Disorders
- Cerebral Palsy and Movement Disorders
- Hip and Femur Fractures
- Bone Metabolism and Diseases
- Body Composition Measurement Techniques
- PARP inhibition in cancer therapy
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Hip disorders and treatments
- Hematopoietic Stem Cell Transplantation
- Nutrition and Health in Aging
- S100 Proteins and Annexins
- Prostate Cancer Treatment and Research
- Neurological and metabolic disorders
- Mast cells and histamine
- Vitamin K Research Studies
- Hematological disorders and diagnostics
- Doping in Sports
- Thallium and Germanium Studies
- Immune Response and Inflammation
- Metabolomics and Mass Spectrometry Studies
Brigham and Women's Hospital
2020-2024
Harvard University
2020-2024
Function Promoting Therapies (United States)
2022-2024
University of Miami
2018-2021
Stanford University
2016-2018
Dominion (United States)
2018
Central University of the Caribbean
2016
Skeletal fractures can result when there are co-morbid conditions that negatively impact bone strength. Fractures represent an important source of morbidity and mortality, especially in older populations. Diabetes mellitus is a metabolic disorder has reached worldwide epidemic proportions increasingly being recognized as risk factor for fracture. Type 1 2 diabetes have different effects on mineral density but share common pathways, which lead to fragility. In this review, we discuss the...
Nicotinamide adenine dinucleotide (NAD) levels decline with aging and age-related in NAD has been postulated to contribute diseases.
ABSTRACT Hematopoiesis depends on a supportive microenvironment. Preclinical studies in mice have demonstrated that osteoblasts influence the development of blood cells, particularly erythrocytes, B lymphocytes, and neutrophils. However, it is unknown whether osteoblast numbers or function impact cell counts humans. We tested hypothesis men with low BMD greater loss decreased circulating erythrocytes lymphocytes increased myeloid cells. performed cross-sectional analysis prospective...
Abstract Context: Extremely low hemoglobin (Hgb) values have been linked to increased fracture risk at different sites. However, careful assessment of clinically defined anemia and is lacking. Objective: To determine whether men with were after accounting for bone mineral density (BMD) loss. Design: Cross-sectional analysis (at visit 3) prospective (from baseline in the Osteoporotic Fractures Men (MrOS), a multisite, longitudinal cohort study. Setting: Six communities United States....
OBJECTIVE To investigate the relationship of osteocalcin (OC), a marker bone formation, and C-terminal cross-linked telopeptide type I collagen (CTX), resorption, with incident diabetes in older women. RESEARCH DESIGN AND METHODS The analysis included 1,455 female participants from population-based Cardiovascular Health Study (CHS) (mean [SD] age 74.6 [5.0] years). cross-sectional association serum total OC CTX levels insulin resistance (HOMA-IR) was examined using multiple linear...
Abstract As there are effective treatments to reduce hip fractures, identification of patients at high risk fracture is important inform efficient intervention strategies. To obtain a new tool for prediction, we developed protein-based score in the Cardiovascular Health Study using an aptamer-based proteomic platform. The predicted incident fractures and improved discrimination two Trøndelag validation cohorts same When transferred antibody-based platform UK Biobank cohort, was strongly...
The clinical impact of arrhythmias on the continuum critical illness is unclear, and data in medical intensive care units (ICU) lacking. In this study, we distinguish between different types evaluate if their distinction importance based ICU length stay mortality outcomes. We performed a retrospective analysis 215 patients community-based teaching hospital ICU. Variables gathered include sociodemographic data, identified interpreted by study team, admission diagnoses coded into mediator...
Low muscle mass (sarcopenia) is a prevalent and major concern in the aging population as well patients with chronic kidney disease (CKD). We hypothesized that sarcopenia an independent predictor of incident progressive CKD increased mortality older men women (≥65 years) from Cardiovascular Health Study. Sarcopenia was defined by bioimpedance-estimated skeletal index (SMI) continuous variable categorically (normal, class I, II). Cox regression hazard ratios (HRs) estimated risk individuals...
Abstract Background A spinal cord injury (SCI) is a devastating, life-changing event that has profoundly deleterious effects on an individual’s health and well-being. Dysregulation of neuromuscular, cardiometabolic, endocrine organ systems following SCI contribute to excess morbidity, mortality poor quality life. As no effective treatments currently exist for SCI, the development novel strategies improve functional status individuals living with are much needed. To address this knowledge...
Most men diagnosed with prostate cancer today have organ-confined disease and low risk of recurrence after radical prostatectomy. Testosterone deficiency in survivors contributes to impaired health-related quality life but testosterone treatment is viewed as a contraindication this population.
Abstract Nicotinamide adenine dinucleotide (NAD + ) depletion has been postulated as a contributor to the severity of COVID‐19; however, no study prospectively characterized NAD and its metabolites in relation disease patients with COVID‐19. We measured 56 hospitalized COVID‐19 two control groups without COVID‐19: (1) 31 age‐ sex‐matched adults comorbidities, (2) 30 comorbidities. Blood concentrations group were only slightly lower than ( p < 0.05); plasma 1‐methylnicotinamide...
Abstract Introduction: Following spinal cord injury (SCI) lower extremity bone mineral density (BMD) losses are as high 40% due to mechanical unloading and autonomic dysfunction. While lumbar spine (LS) BMD appears be relatively spared, evidence suggests by dual-energy radiographic absorptiometry (DXA) may overlook pathology in this region. Trabecular Bone Score (TBS), representative of microarchitecture, a more informative measurement LS SCI. Our objective was determine differences TBS...