A5085834760- Cardiac Imaging and Diagnostics
- Cerebrovascular and Carotid Artery Diseases
- Coronary Interventions and Diagnostics
- Cardiac Valve Diseases and Treatments
- Aortic aneurysm repair treatments
- Infective Endocarditis Diagnosis and Management
- Medical Imaging Techniques and Applications
- Aortic Disease and Treatment Approaches
- Advanced X-ray and CT Imaging
- Cardiovascular Disease and Adiposity
- Acute Myocardial Infarction Research
- Infectious Aortic and Vascular Conditions
- COVID-19 Clinical Research Studies
- Aortic Thrombus and Embolism
- Radiomics and Machine Learning in Medical Imaging
- Cardiac Structural Anomalies and Repair
- Assisted Reproductive Technology and Twin Pregnancy
- Reproductive Health and Technologies
- Clinical practice guidelines implementation
- Prenatal Screening and Diagnostics
- Kawasaki Disease and Coronary Complications
- Cardiovascular Health and Disease Prevention
- Cardiac, Anesthesia and Surgical Outcomes
- Cancer-related molecular mechanisms research
- Cardiac and Coronary Surgery Techniques
University of Edinburgh
2012-2025
British Heart Foundation
2016-2025
University Hospitals Bristol NHS Foundation Trust
2019-2024
Cedars-Sinai Medical Center
2020-2023
NIHR Bristol Cardiovascular Biomedical Research Unit
2020-2023
University of Bristol
2020-2023
University Hospitals Bristol and Weston NHS Foundation Trust
2023
Kaiser Permanente
2023
Bristol Royal Infirmary
2019-2022
University of Leicester
2020
The use of non-invasive imaging to identify ruptured or high-risk coronary atherosclerotic plaques would represent a major clinical advance for prevention and treatment artery disease. We used combined PET CT using the radioactive tracers (18)F-sodium fluoride ((18)F-NaF) (18)F-fluorodeoxyglucose ((18)F-FDG).In this prospective trial, patients with myocardial infarction (n=40) stable angina underwent (18)F-NaF (18)F-FDG PET-CT, invasive angiography. uptake was compared histology in carotid...
Background— The pathophysiology of aortic stenosis is incompletely understood, and the relative contributions valvular calcification inflammation to disease progression are unknown. Methods Results— Patients with sclerosis mild, moderate, severe were compared prospectively age- sex-matched control subjects. Aortic valve severity was determined by echocardiography. Calcification in assessed 18F-sodium fluoride (18F-NaF) 18F-fluorodeoxyglucose (18F-FDG) uptake use positron emission tomography....
Background— Phenotypic switching of vascular smooth muscle cells from a contractile to synthetic state is implicated in diverse pathologies, including atherogenesis, plaque stabilization, and neointimal hyperplasia. However, very little known about the role long noncoding RNA (lncRNA) during this process. Here, we investigated for lncRNAs cell biology pathology. Methods Results— Using sequencing, identified >300 whose expression was altered human saphenous vein following stimulation with...
Background— Inflammation following acute myocardial infarction (MI) has detrimental effects on reperfusion, remodelling, and ventricular function. Magnetic resonance imaging using ultrasmall superparamagnetic particles of iron oxide can detect cellular inflammation in tissues, we therefore explored their role MI humans. Methods Results— Sixteen patients with ST-segment elevation were recruited to undergo 3 sequential magnetic scans within 5 days admission at baseline, 24 48 hours no infusion...
Lowering the diagnostic threshold for troponin is controversial because it may disproportionately increase diagnosis of myocardial infarction in patients without acute coronary syndrome. We assessed impact lowering on incidence, management, and outcome with type 2 or injury.Consecutive elevated plasma I concentrations (≥50 ng/L; n = 2929) were classified 1 (50%) infarction, injury (48%), 3 to 5 (2%) before after from 200 50 ng/L a sensitive assay. Event-free survival death recurrent was...
AimsThe pathophysiology of aortic stenosis shares many similarities with atherosclerosis and skeletal bone formation. Using non-invasive imaging, we compared valve calcification inflammation activity that measured in bone.
Background Preclinical data suggest that an acute inflammatory response following myocardial infarction (MI) accelerates systemic atherosclerosis. Using combined positron emission and computed tomography, we investigated whether this phenomenon occurs in humans. Methods Results Overall, 40 patients with MI stable angina underwent thoracic 18F‐fluorodeoxyglucose tomography scan. Radiotracer uptake was measured aortic atheroma nonvascular tissue (paraspinal muscle). In 1003 enrolled the Global...
Background We examined the effect of oral SIRT 1 activator SRT 2104 on cardiovascular function in otherwise healthy cigarette smokers. Methods and Results Twenty‐four smokers participated a randomized double‐blind, placebo‐controlled crossover trial received 28 days (2.0 g/day) or matched placebo. Plasma concentrations, serum lipid profile, plasma fibrinolytic factors, markers platelet monocyte activation were measured at baseline end each treatment period together with an assessment forearm...
Ruptured coronary atherosclerotic plaques commonly cause acute myocardial infarction. It has recently been shown that active microcalcification in the arteries, one of features characterizes vulnerable at risk rupture, can be imaged using <sup>18</sup>F-NaF PET. We aimed to determine whether a motion correction technique applied gated PET images could enhance image quality and improve uptake estimates. <b>Methods:</b> Seventeen patients with infarction (<i>n</i> = 7) or stable angina 10)...
Coronary <sup>18</sup>F-sodium fluoride (<sup>18</sup>F-NaF) PET and CT angiography–based quantitative plaque analysis have shown promise in refining risk stratification patients with coronary artery disease. We combined both of these novel imaging approaches to develop an optimal machine-learning model for the future myocardial infarction stable <b>Methods:</b> Patients known disease underwent <sup>18</sup>F-NaF angiography on a hybrid PET/CT scanner. Machine-learning by extreme gradient...
Aortic atherosclerosis represents an important contributor to ischemic stroke risk. Identifying patients with high-risk aortic atheroma could improve preventative treatment strategies for future stroke.The purpose of this study was investigate whether thoracic 18F-sodium fluoride positron emission tomography (PET) the identification at highest risk stroke.In a post hoc observational cohort study, we quantified and coronary activity in 461 stable cardiovascular disease undergoing PET combined...
Inflammation is critical in the pathogenesis of abdominal aortic aneurysm (AAA) disease. Combined (18)F-fludeoxyglucose ((18)F-FDG) positron emission tomography with computed (PET-CT) and ultrasmall superparamagnetic particles iron oxide (USPIO)-enhanced magnetic resonance imaging (MRI) are non-invasive methods assessing tissue inflammation. The aim this study was to compare these techniques patients AAA.Fifteen asymptomatic AAA diameter 46 ± 7 mm underwent PET-CT (18)F-FDG, T2*-weighted MRI...
Objectives Intraplaque angiogenesis and inflammation are key promoters of atherosclerosis mediated by the alpha-V beta-3 (α v β 3 ) integrin pathway. We investigated applicability α -integrin receptor-selective positron emission tomography (PET) radiotracer 18F-fluciclatide in assessing human aortic atherosclerosis. Methods Vascular binding was evaluated using ex vivo analysis carotid endarterectomy samples with autoradiography immunohistochemistry, kinetic modelling following...
Assessments of coronary disease activity with
Objective (1): To develop and validate a machine learning (ML) model using radiomic features (RFs) extracted from [18F]FDG PET-CT to predict abdominal aortic aneurysm (AAA) growth rate. Methods (2): This retrospective study included 98 internal 55 external AAA patients undergoing PET-CT. RFs were manual segmentations of AAAs PyRadiomics. Recursive feature elimination (RFE) reduced for optimisation. A multi-layer perceptron (MLP) was developed prediction compared against Random Forest (RF),...
To estimate trends in good perinatal outcomes (singleton live births at term with birthweight more than 2,500 g) among after assisted reproductive technology the United States from 2000 to 2008, and associated factors singletons 2008.
Background— Abdominal aortic aneurysm (AAA) wall inflammation and mechanical structural stress may influence AAA expansion lead to rupture. We hypothesized a positive correlation between fluorine-18-labeled 2-deoxy-2-fluoro- d -glucose ( 18 F-FDG) positron emission tomography–defined inflammation. also explored the of computed tomography–derived morphology composition, including intraluminal thrombus, on both variables. Methods Results— Twenty-one patients (19 males) with AAAs below surgical...