A5080125880- Cardiac Fibrosis and Remodeling
- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Acute Myocardial Infarction Research
- Peripheral Artery Disease Management
- Cardiac, Anesthesia and Surgical Outcomes
- Antiplatelet Therapy and Cardiovascular Diseases
- Eosinophilic Disorders and Syndromes
- Signaling Pathways in Disease
- Cardiac Health and Mental Health
- MicroRNA in disease regulation
- Hormonal Regulation and Hypertension
- Inflammatory Biomarkers in Disease Prognosis
- Hemodynamic Monitoring and Therapy
- Cardiac Arrest and Resuscitation
- Extracellular vesicles in disease
- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Immune cells in cancer
- Adipokines, Inflammation, and Metabolic Diseases
- Apelin-related biomedical research
- Cancer-related molecular mechanisms research
- Aortic aneurysm repair treatments
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Protease and Inhibitor Mechanisms
Wythenshawe Hospital
2023
Manchester University
2023
British Heart Foundation
2004-2020
University of Edinburgh
2015-2020
The Queen's Medical Research Institute
2017-2020
Queen's Medical Centre
2020
Basildon and Thurrock University Hospitals NHS Foundation Trust
2018
Essex Cardiothoracic Centre
2018
Centre for Immunity, Infection and Evolution
2018
Centre for Inflammation Research
2018
Abstract Neutralizing injurious stimuli, proinflammatory mediator catabolism, and polymorphonuclear leukocyte (PMN) clearance are determinants of inflammatory resolution. To this, we recently added innate-type lymphocyte repopulation as being central for restoring postinflammation tissue homeostasis with a role in controlling innate immune–mediated responses to secondary infection. However, although macrophages dominate resolution, their phenotype physiology once inflammation abates unknown....
Background Preclinical data suggest that an acute inflammatory response following myocardial infarction (MI) accelerates systemic atherosclerosis. Using combined positron emission and computed tomography, we investigated whether this phenomenon occurs in humans. Methods Results Overall, 40 patients with MI stable angina underwent thoracic 18F‐fluorodeoxyglucose tomography scan. Radiotracer uptake was measured aortic atheroma nonvascular tissue (paraspinal muscle). In 1003 enrolled the Global...
In ST-segment elevation myocardial infarction of both patients and mice, there was a decline in blood eosinophil count, with activated eosinophils recruited to the infarct zone. Eosinophil deficiency resulted attenuated anti-inflammatory macrophage polarization, enhanced inflammation, increased scar size, deterioration structure function. Adverse cardiac remodeling setting prevented by interleukin-4 therapy.
Renin-angiotensin systems may mediate cardiovascular disease pathogenesis through a balance of actions angiotensin II on (potentially proatherogenic) constitutive type 1 (AT1R) and antiatherogenic) inducible 2 (AT2R) receptors. We explored such potential roles in prospective candidate gene association study. Cardiovascular end points (fatal, nonfatal, silent myocardial infarction coronary artery bypass surgery/angioplasty) were documented among 2579 healthy UK men (mean age, 56.1+/-3.5...
Cardiopulmonary bypass during cardiac surgery can result in a shortfall oxygen delivery relative to demand, marked by decrease muscle tissue saturation as blood flow is redistributed vital organs. Such "tissue shock" might impair postoperative recovery.To determine the association of changes with outcome patients.In 74 adults undergoing surgery, thenar eminence was recorded using near-infrared spectroscopy before and induction anesthesia, throughout intensive care unit until extubation or...
The aim of this study was to compare rates target lesion revascularisation (TLR) and total mortality between South Asians (SAs) White Europeans (WEs) following percutaneous coronary intervention (PCI).We followed a cohort 293 SAs 865 WEs patients admitted for elective or urgent PCI de novo lesions. For each patient, baseline cardiovascular risk factors angiographic data were obtained. Patients had long-term follow-up all-cause TLR.Patients up over median period 54 months (inter-quartile...
BackgroundExtracellular microRNAs enter kidney cells and modify gene expression. We used a Dicer-hepatocyte-specific microRNA conditional-knock-out (Dicer-CKO) mouse to investigate transfer from liver kidney.MethodsDicerflox/flox mice were treated with Cre recombinase-expressing adenovirus (AAV8) selectively inhibit hepatocyte production (Dicer-CKO). Organ expression was measured in health following paracetamol toxicity. The functional consequence of hepatic determined by measuring the...
We examined whether complication rates and resource utilization among elderly patients undergoing coronary artery bypass grafting (CABG) differed from their younger counterparts. A retrospective review of prospectively collected data was conducted 2936 first-time isolated CABG. Demographic baseline clinical characteristics were collected, grouped according to age into those <75 years (n=2424, younger) ≥75 (n=512, older). Major postoperative complications recorded on indicators utilization,...
Activation of the innate immune response following myocardial infarction (MI) is essential for infarct repair. Preclinical models MI commonly use C57BL/6 mice, which have a type 1-dominant response, whereas other mouse strains such as BALB/c mice 2-dominant response. We compared and to investigate whether predisposition towards proinflammatory phenotype influences dynamics associated healing risk cardiac rupture. was induced by permanent coronary artery ligation in 12-15-week-old male...
Several inflammatory diseases including multiple sclerosis and bowel disease have been associated with dysfunctional and/or reduced numbers of Foxp3+ regulatory T cells (Treg). While numerous mechanisms action discovered by which Treg can exert their function, disease-specific requirements remain largely unknown. We found that the integrin alpha v, pair several beta subunits 8, is highly upregulated in at sites inflammation. Using mice lacked v expression or 8 specifically Treg, we...
<h3>Background</h3> Low peripheral blood eosinophil count is associated with increased risk of mortality in ischaemic heart disease patients. Eosinophils contain preformed IL-4 within their cytoplasmic granules, which promotes an anti-inflammatory response and tissue repair. Whether eosinophils are recruited to the infarct zone have a role regulating repair currently unknown. <h3>Purpose</h3> This study sought investigate healing. <h3>Methods</h3> MI was induced by permanent coronary artery...
The assessment of myocardial ischemia represents a cornerstone in our approach to coronary artery disease. Indeed many the clinical decisions we make revolve around results stress testing, luminal stenoses and, more recently, fractional flow reserve measurements. Whilst is often useful with respect diagnosis and its treatment important terms symptom relief, whether directly leads adverse cardiovascular outcomes, particular infarction, much controversial. this one key questions facing...
ABSTRACT Background Eosinophil count predicts outcome following myocardial infarction (MI) and eosinophils regulate tissue repair regeneration in extra-cardiac settings. Objectives To investigate the role of regulating inflammation, remodelling MI. Methods Blood eosinophil was assessed 732 patients undergoing primary percutaneous coronary intervention for ST-segment elevation MI (STEMI). Experimental induced wild-type (WT) eosinophil-depleted mice (ΔdblGATA or anti-Siglec F antibody...
Abstract A technology based on velocity ratio indices is described for application in the myocardium. Angle-independent Doppler indices, such as pulsatility index, which employ ratios, can be measured even if ultrasound beam vector at moving target and motion are not a known plane. The unknown plane situation often encountered when an interrogates sites velocities employed index calculation must close to same or opposite directions. independent of angle 3D space 1D strain speckle tracking....
Using their experiences of transferring between universities, <b>Nishanthan Rajakumaraswamy</b>, <b>Iqbal Toor</b>, and <b>Geraint Thomas</b> explore the options for medical students wanting to study somewhere else
<h3>Background</h3> Out of hospital cardiac arrest (OOHCA) due to acute myocardial infarction (MI) is a leading cause sudden death. Survival-to-discharge rates for OOHCA are reported be as low 10%, however there limited UK data on survival beyond 30 days. Limited studies, survivors post MI who survive discharge, report longer-term 78-92%. We sought contemporary from single tertiary centre. <h3>Methods</h3> All patients undergoing percutaneous coronary intervention (PCI) at our institution...
<h3>Introduction</h3> Percutaneous coronary intervention (PCI) is increasingly used for symptomatic relief and prognostic benefit. However, it not known if differences in outcomes exist between South Asians White Europeans offered PCI. <h3>Methods</h3> We followed a cohort of 293 865 admitted elective or urgent Baseline cardiovascular risk factors angiographic data were obtained. Patients had long-term follow-up (54 (IQR 47–65) months) all-cause mortality target lesion revascularisation...
Near infra-red spectroscopy is a novel method for rapid and non-invasive assessment of tissue oxygen saturation (Sto2). An association between Sto2 delivery has been demonstrated during shock, trauma resuscitation. We sought to explore anaesthesia surgery its with outcome. Seventy-four adult patients undergoing first-time, elective, single procedure cardiac requiring cardiopulmonary bypass (CPB) were studied. was measured from the thenar eminence (Inspectra Tissue Spectrometer Model 325;...