A5005747653- Cardiac Imaging and Diagnostics
- Chemotherapy-induced cardiotoxicity and mitigation
- Acute Myocardial Infarction Research
- Cancer Treatment and Pharmacology
- Cardiac, Anesthesia and Surgical Outcomes
- Coronary Interventions and Diagnostics
- Cardiovascular Disease and Adiposity
- Cancer-related cognitive impairment studies
- Cardiac and Coronary Surgery Techniques
- Advanced MRI Techniques and Applications
- Cardiac Ischemia and Reperfusion
- Protease and Inhibitor Mechanisms
- Cardiac Valve Diseases and Treatments
- Cerebrovascular and Carotid Artery Diseases
- Infective Endocarditis Diagnosis and Management
- Blood Coagulation and Thrombosis Mechanisms
- Organ Transplantation Techniques and Outcomes
- Viral Infections and Immunology Research
- Health Systems, Economic Evaluations, Quality of Life
- Cardiac Fibrosis and Remodeling
- Atherosclerosis and Cardiovascular Diseases
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiac Arrest and Resuscitation
- Signaling Pathways in Disease
- Peptidase Inhibition and Analysis
Edinburgh Royal Infirmary
2012-2024
NHS Lothian
2013-2024
University of Edinburgh
2014-2024
British Heart Foundation
2015-2024
Western General Hospital
2006-2024
University of Glasgow
2018
NHS Forth Valley
2014
Golden Jubilee National Hospital
2012
Institute of Cardiology
2010
Aarhus University
2008
Background— Inflammation following acute myocardial infarction (MI) has detrimental effects on reperfusion, remodelling, and ventricular function. Magnetic resonance imaging using ultrasmall superparamagnetic particles of iron oxide can detect cellular inflammation in tissues, we therefore explored their role MI humans. Methods Results— Sixteen patients with ST-segment elevation were recruited to undergo 3 sequential magnetic scans within 5 days admission at baseline, 24 48 hours no infusion...
BACKGROUND: Anthracycline-induced cardiotoxicity has a variable incidence, and the development of left ventricular dysfunction is preceded by elevations in cardiac troponin concentrations. Beta-adrenergic receptor blocker renin-angiotensin system inhibitor therapies have been associated with modest cardioprotective effects unselected patients receiving anthracycline chemotherapy. METHODS: In multicenter, prospective, randomized, open-label, blinded end-point trial, breast cancer non-Hodgkin...
Abstract Atherosclerosis is a chronic inflammatory disease affecting arterial vessels. Strategies to reduce the responses of endothelial cells and macrophages may slow lesion development prevent complications such as plaque rupture. The human protease neutrophil elastase (HNE), oxidized low density lipoprotein, LPS, TNF-α were chosen model stimuli wall inflammation led production chemokine IL-8 in cells. To counteract activity HNE, we have examined effects adenoviral gene delivery...
Non-alcoholic steatohepatitis (NASH) is an increasing cause of liver disease necessitating transplantation.In patients with advanced NASH, there are often coexistent clinical issues that impact on the outcome transplantation.There no guidelines for assessment and management NASH undergoing transplantation.A group was therefore invited by Council British Transplant Society (BTS) to prepare before after transplantation.
Macrophages play a central role in the cellular inflammatory response to myocardial infarction (MI) and predict subsequent clinical outcomes. We aimed assess temporal changes inflammation tissue oedema patients with acute MI using ultrasmallsuperparamagnetic particles of iron oxide (USPIO)-enhanced MRI.Thirty-one were recruited following followed up for 3 months repeated T2 USPIO-enhanced T2*-mapping MRI. Regions interest categorised into infarct, peri-infarct remote zones, compared control...
Myocardial inflammation and injury occur during coronary artery bypass graft (CABG) surgery. We aimed to characterise these processes routine CABG surgery inform the diagnosis of type 5 myocardial infarction. assessed 87 patients with stable disease who underwent elective inflammation, infarction were using plasma inflammatory biomarkers, high-sensitivity cardiac troponin I (hs-cTnI) magnetic resonance imaging (CMR) both late gadolinium enhancement (LGE) ultrasmall superparamagnetic...
<h3>Background</h3> Elafin is a potent endogenous neutrophil elastase inhibitor that protects against myocardial inflammation and injury in preclinical models of ischaemic-reperfusion injury. We investigated whether elafin could inhibit ischaemia-reperfusion induced during coronary artery bypass graft (CABG) surgery. <h3>Methods results</h3> In randomised double-blind placebo-controlled parallel group clinical trial, 87 patients undergoing CABG surgery were 1:1 to intravenous 200 mg or...
Computed tomography (CT) can perform comprehensive cardiac imaging. We compared CT coronary angiography (CTCA) and myocardial perfusion (CTP) with 15O-water positron emission (PET) invasive (ICA) fractional flow reserve (FFR). 51 patients (63 (61–65) years, 80 % male) known/suspected artery disease (CAD) underwent 320-multidetector CTCA followed by "snapshot" adenosine stress CTP. Of these 22 PET 47 ICA/FFR. Obstructive CAD was defined as stenosis >50 CTP hypoperfusion, ICA >70 or FFR <0.80....
Objectives Ultrasmall superparamagnetic particles of iron oxide (USPIO)-enhanced MRI can detect tissue-resident macrophage activity and identify cellular inflammation within tissues. We hypothesised that USPIO-enhanced would provide a non-invasive imaging technique improve the diagnosis management patients with acute myocarditis. Methods Ten volunteers 14 suspected myocarditis underwent T2, T2* late gadolinium enhancement (LGE) 3T MRI, further at 24 hours after USPIO (ferumoxytol, 4 mg/kg)...
Treatment advances have improved cancer-related outcomes and shifted interest towards minimising long-term iatrogenic complications, particularly chemotherapy-related cardiotoxicity. High-sensitivity cardiac troponin I (hs-cTnI) assays accurately quantify very low concentrations of plasma enable early detection cardiomyocyte injury prior to the development myocardial dysfunction. The profile hs-cTnI in response anthracycline-based treatment has not previously been described.This was a...
Ultrasmall superparamagnetic particles of iron oxide (USPIO)-enhanced magnetic resonance imaging (MRI) can detect tissue-resident macrophage activity and identify cellular inflammation. Clinical studies using this technique are now emerging. We aimed to report a range normal R2* values at 1.5 3 T in the myocardium other tissues following ferumoxytol administration, outline methodology used suggest solutions commonly encountered analysis problems.
Aims Stent underexpansion and malapposition are associated with adverse outcomes following percutaneous coronary intervention, but detection treatment can be challenging in the presence of extensive artery calcification. Frequency domain optical coherence tomography (FD-OCT) is a novel intravascular imaging technique greater spatial resolution than ultrasound (IVUS) its role calcification remains unclear. We sought to determine utility FD-OCT compared IVUS guide intervention patients severe...
The resolution of inflammation is dependent on recognition and phagocytic removal apoptotic cells by macrophages. Receptors for are sensitive to degradation human neutrophil elastase (HNE). We show in the present study that HNE cleaves macrophage cell surface CD14 so doing, reduces lymphocytic (Mutu 1). Using an improved method adenovirus‐mediated transfection macrophages with inhibitor elafin, we demonstrate elafin overexpression prevents cleavage restores This approach genetic modification...