A5068236105- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Meta-analysis and systematic reviews
- Cardiac Imaging and Diagnostics
- Stroke Rehabilitation and Recovery
- Intracranial Aneurysms: Treatment and Complications
- Health Systems, Economic Evaluations, Quality of Life
- Delphi Technique in Research
- Cardiovascular Health and Disease Prevention
- Statistical Methods in Clinical Trials
- Venous Thromboembolism Diagnosis and Management
- Antiplatelet Therapy and Cardiovascular Diseases
- Asthma and respiratory diseases
- Intracerebral and Subarachnoid Hemorrhage Research
- Cardiac, Anesthesia and Surgical Outcomes
- Cystic Fibrosis Research Advances
- Clinical practice guidelines implementation
- Respiratory viral infections research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Ethics in Clinical Research
- Vascular Malformations Diagnosis and Treatment
- Neonatal Respiratory Health Research
- Acute Myocardial Infarction Research
- Bone health and treatments
- Pediatric health and respiratory diseases
University of Edinburgh
2016-2025
Asthma UK
2020-2025
Asthma UK Centre for Applied Research
2020-2025
Health and Education Research Management and Epidemiologic Services (United States)
2023
Hartford Financial Services (United States)
2023
Edinburgh College
2023
Institute of Occupational Medicine
2020-2023
Institute for Community Living
2023
Allen Institute
2021
Broadmoor Hospital
2020
Few systematic reviews containing meta-analyses are complete without a forest plot. But what plots, and where did they come from? #### Summary points Forest plots show the information from individual studies that went into meta-analysis at glance They amount of variation between an estimate overall result Forest in various forms, have been published for about 20 years During this time, improved, but it is still not easy to draw them most standard computer packages In typical plot,...
<h3>Importance</h3> While guidance on statistical principles for clinical trials exists, there is an absence of covering the required content analysis plans (SAPs) to support transparency and reproducibility. <h3>Objective</h3> To develop recommendations a minimum set items that should be addressed in SAPs trials, developed with input from statisticians, previous guideline authors, journal editors, regulators, funders. <h3>Design</h3> Funders regulators (n = 39) randomized were contacted...
In a prospective, multicenter, randomized controlled trial, 4,146 patients were to receive standard care or plus coronary computed tomography angiography (CCTA). The purpose of this study was explore the consequences CCTA-assisted diagnosis on invasive angiography, preventive treatments, and clinical outcomes. post hoc analyses, we assessed changes in outcomes using national electronic health records. Despite similar overall rates (409 vs. 401; p = 0.451), less likely demonstrate normal...
<b>Objective</b> To test the effectiveness of telemonitoring integrated into existing clinical services such that intervention and control groups have access to same care. <b>Design</b> Researcher blind, multicentre, randomised controlled trial. <b>Setting</b> UK primary care (Lothian, Scotland). <b>Participants</b> Adults with at least one admission for chronic obstructive pulmonary disease (COPD) in year before randomisation. We excluded people who had other significant lung disease, were...
Results of small trials indicate that fluoxetine might improve functional outcomes after stroke. The FOCUS trial aimed to provide a precise estimate these effects.FOCUS was pragmatic, multicentre, parallel group, double-blind, randomised, placebo-controlled done at 103 hospitals in the UK. Patients were eligible if they aged 18 years or older, had clinical stroke diagnosis, enrolled and randomly assigned between 2 days 15 onset, focal neurological deficits. allocated 20 mg matching placebo...
<h3>Importance</h3> Critical illness results in disability and reduced health-related quality of life (HRQOL), but the optimum timing components rehabilitation are uncertain. <h3>Objective</h3> To evaluate effect increasing physical nutritional plus information delivered during post–intensive care unit (ICU) acute hospital stay by dedicated assistants on subsequent mobility, HRQOL, prevalent disabilities. <h3>Design, Setting, Participants</h3> A parallel group, randomized clinical trial with...
Paracetamol poisoning is common worldwide. It treated with intravenous acetylcysteine, but the standard regimen complex and associated frequent adverse effects related to concentration, which can cause treatment interruption. We aimed ascertain whether could be reduced either a shorter modified acetylcysteine schedule, antiemetic pretreatment, or both.We undertook double-blind, randomised factorial study at three UK hospitals, between Sept 6, 2010, Dec 31, 2012. randomly allocated patients...
Background and Purpose — We sought to investigate the apparently high risk of early death after an ischemic stroke among patients with atrial fibrillation (AF), identify main factors associated death, assess effect treatment different doses subcutaneous unfractionated heparin (UFH) given within 48 hours. Methods studied occurrence major clinical events 14 days 18 451 from International Stroke Trial, first for all groups combined. Then, AF, we examined effects UFH started hours continued...
Although the physical and, to a lesser extent, emotional outcome of stroke survivors has been well documented, there are far fewer data relating outcomes those who care for them. We aimed describe caring patients and identify both patient caregiver factors that associated with poor outcomes.As part randomized trial evaluate family worker, we identified 417 (67% all referrals our institution). followed up 376 whom 246 at 6-month follow-up interview. The caregivers were asked complete 2...
1. Attitudes of doctors to the Committee on Safety Medicines' (CSM) adverse drug reaction (ADR) reporting scheme were investigated in order assess their understanding purposes and identify reasons for failing report suspected reactions. 2. A postal questionnaire letter invitation sent 500 who randomly selected from 1992 Medical Directory. reminder a second copy non-responders after 4 weeks. 3. 284 (57%) responded questionnaire. Of these, 179 (63%) stated that they had previously reported an...
<b>Objective</b> To determine if an intervention consisting of telemonitoring and supervision by usual primary care clinicians home self measured blood pressure optional patient decision support leads to clinically important reductions in daytime systolic diastolic ambulatory patients with uncontrolled pressure. <b>Design</b> Multicentre randomised controlled trial. <b>Setting</b> 20 practices south east Scotland. <b>Participants</b> 401 people aged 29-95 years (mean measurement ≥135/85 mm...
To estimate the impact on long term survival of functional status at six months after ischaemic stroke.Prospective cohort study. Settings Three cohorts: Oxfordshire community stroke project, Lothian register, and first international trial (in United Kingdom).7710 patients with registered between 1981 2000 followed up for a maximum 19 years.Functional assessed modified Rankin scale or "two simple questions." Mortality during follow-up. Survival analysis Kaplan-Meier curves, log rank test,...
Second edition by S.C. Chow, J. Shao, and H. Wang, Boca Raton, Chapman Hall/CRC Press, 2008, xiv+465 pp., £49.99 or US$89.95 (hardback), ISBN 978-1-58488-982-9 Sample size calculation is an ess...
BackgroundThe American Academy of Pediatrics recommends a permissive hypoxaemic target for an oxygen saturation 90% children with bronchiolitis, which is consistent the WHO recommendations targets in lower respiratory tract infections. No evidence exists to support this threshold. We aimed assess whether or higher management supplementation was equivalent normoxic 94% infants admitted hospital viral bronchiolitis.MethodsWe did parallel-group, randomised, controlled, equivalence trial aged 6...
BACKGROUND AND PURPOSE: Coated coils have been in clinical use for several years without robust evidence to determine their safety/efficacy. The HydroCoil Endovascular Aneurysm Occlusion and Packing Study (HELPS) addresses this deficiency the embolic system. This article reports periprocedural safety/operator-assessed angiographic results from HELPS. MATERIALS METHODS: Patients were randomized hydrogel coil or control arms by using concealed allocation with minimization matching groups. Any...