A5063851108- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Dementia and Cognitive Impairment Research
- Cardiovascular Health and Disease Prevention
- Atrial Fibrillation Management and Outcomes
- Stroke Rehabilitation and Recovery
- Venous Thromboembolism Diagnosis and Management
- Intracerebral and Subarachnoid Hemorrhage Research
- Antiplatelet Therapy and Cardiovascular Diseases
- Traumatic Brain Injury and Neurovascular Disturbances
- Alzheimer's disease research and treatments
- Blood Pressure and Hypertension Studies
- Neurobiology of Language and Bilingualism
- Neurological Disease Mechanisms and Treatments
- Parkinson's Disease Mechanisms and Treatments
- Cardiac Imaging and Diagnostics
- Intracranial Aneurysms: Treatment and Complications
- Health Systems, Economic Evaluations, Quality of Life
- S100 Proteins and Annexins
- Blood Coagulation and Thrombosis Mechanisms
- Advanced Neuroimaging Techniques and Applications
- Neurological Disorders and Treatments
- Cardiovascular Syncope and Autonomic Disorders
- Neurological disorders and treatments
- Clinical practice guidelines implementation
Erasmus MC
2015-2024
Erasmus University Rotterdam
2013-2023
Health and Education Research Management and Epidemiologic Services (United States)
2021-2023
Bordeaux Population Health
2022
Université de Bordeaux
2022
UCLA Medical Center
2022
Harbor–UCLA Medical Center
2022
National University of Singapore
2022
Amsterdam UMC Location University of Amsterdam
1992-2021
Radboud University Medical Center
2017-2021
In patients with acute ischemic stroke caused by a proximal intracranial arterial occlusion, intraarterial treatment is highly effective for emergency revascularization. However, proof of beneficial effect on functional outcome lacking.
Interobserver agreement for the assessment of handicap in stroke patients was investigated a group 10 senior neurologists and 24 residents from two centers. One hundred were separately interviewed by physicians different combinations. The degree recorded each observer on modified Rankin scale, which has six grades (0-5). rates corrected chance (kappa statistics). Both agreed 65 patients; they differed one grade 32 3 patients. Kappa all pairwise observations 0.56; value weighted kappa (with...
Background Noninvasive assessment of intima-media thickness (IMT) is widely used in observational studies and trials as an intermediate or proxy end point for cardiovascular disease. However, data showing that IMT predicts disease are limited. We studied whether common carotid related to future stroke myocardial infarction. Methods Results a nested case-control approach among 7983 subjects aged ≥55 years participating the Rotterdam Study. At baseline (March 1990 through July 1993),...
Silent brain infarcts are frequently seen on magnetic resonance imaging (MRI) in healthy elderly people and may be associated with dementia cognitive decline.We studied the association between silent risk of decline 1015 participants prospective, population-based Rotterdam Scan Study, who were 60 to 90 years age free stroke at base line. Participants underwent neuropsychological testing cerebral MRI line 1995 1996 again 1999 2000 monitored for throughout study period. We performed Cox...
Background and Purpose— Silent brain infarcts white matter lesions are associated with an increased risk of subsequent stroke in minor patients. In healthy elderly people, silent common, but little is known about their relevance. We examined the these general population. Methods— The Rotterdam Scan Study a population-based prospective cohort study among 1077 people. presence was scored on cerebral MRI scans obtained from 1995 to 1996. Participants were followed for average 4.2 years....
Aspirin is known to improve the outcome of patients who have had a cerebral transient ischemic attack, but optimal dose aspirin remains uncertain. Experimental evidence indicates that 30 mg daily alters platelet aggregation more favorably than 300-mg currently used in after attack or minor stroke.
Cerebral small-vessel disease is common in older people and may contribute to the development of dementia. The objective present study was evaluate relationship between measures cerebral on MRI rate decline specific cognitive domains participants from prospective, population-based Rotterdam Scan Study. Participants were 60-90 years age free dementia at baseline 1995-1996. White matter lesions (WML), infarcts generalized brain atrophy assessed MRI. We performed neuropsychological testing...
Abstract Cerebral blood flow (CBF) velocity is decreased in patients with Alzheimer's disease. It being debated whether this reflects diminished demand because of advanced neurodegeneration or that cerebral hypoperfusion contributes to dementia. We examined the relation CBF as measured transcranial Doppler dementia and markers incipient (ie, cognitive decline hippocampal amygdalar atrophy on magnetic resonance imaging) 1,730 participants Rotterdam Study aged 55 years older. Cognitive 6.5...
Background and Purpose— The prevalence of silent brain infarcts in healthy elderly people is high, these lesions are associated with an increased risk stroke. incidence unknown. We investigated the cardiovascular factors for infarcts. Methods— Rotterdam Scan Study a prospective, population-based cohort study 1077 participants 60 to 90 years age. All underwent cranial MRI 1995 1996, 668 had second 1999 2000 (response rate, 70%) mean interval 3.4 years. assessed by interview physical...
Background and Purpose— The role of uric acid as a risk factor for myocardial infarction is controversial, little known about its stroke. Recent evidence suggests that may be an important causal agent in cardiovascular disease, example, by inducing renal disease hence hypertension. We investigated the association between serum coronary heart stroke large prospective population-based study. Methods— study was based on 4385 participants Rotterdam Study who, at baseline (1990 to 1993), were ≥55...
Background and Purpose— Cerebral white matter lesions lacunar infarcts are small vessel disease-related lesions, which associated with cognitive decline dementia. We aimed to assess the relationship between risk factors, effect modifiers, progression of these lesions. Furthermore, we studied consequences lesion progression. Methods— Six hundred sixty-eight people, aged 60 90 years, underwent repeated MRI scanning neuropsychological testing within 3-year follow-up. rated incident change in...
<h3>Objective</h3> To study the association between white matter lesions (WML) in specific locations and risk of dementia. <h3>Design</h3> The Rotterdam Scan Study, a prospective population-based cohort study. We scored periventricular subcortical WML on magnetic resonance imaging observed participants until January 2002 for incident <h3>Setting</h3> General population. <h3>Participants</h3> included 1077 people aged 60 to 90 years who did not have dementia at baseline. <h3>Main Outcome...
Lipoprotein-associated phospholipase A2 (Lp-PLA2) has been proposed as an inflammatory marker of cardiovascular disease. In the present study, we investigated whether Lp-PLA2 is independent predictor coronary heart disease and ischemic stroke.The Rotterdam Study a population-based follow-up study in 7983 subjects > or =55 years age. We performed case-cohort including 308 cases, 110 stroke random sample 1820 subjects. used Cox proportional-hazard models with modification standard errors based...
Cerebral hypoperfusion has previously been associated with mild cognitive impairment and dementia in various cross-sectional studies, but whether precedes neurodegeneration is unknown. We prospectively determined the association of cerebral perfusion subsequent decline development dementia.Between 2005 2012, we measured blood flow by 2-dimensional phase-contrast magnetic resonance imaging participants population-based Rotterdam Study without dementia. (mL/100mL/min) risk (until 2015) using a...
Cross-sectional reports suggest that statin users are less likely to have Alzheimer disease (AD). Prospective studies provided inconsistent evidence. Moreover, it is unclear whether the association differs for lipophilic statins, those could more easily pass blood-brain barrier and hydrophilic statins.To prospectively evaluate use of statins associated with risk AD, determine associations differ statins.6992 participants prospective, population-based Rotterdam Study were followed, from...
To investigate whether dementia incidence has changed over the last 2 decades.We compared in independent subcohorts of persons aged 60-90 years from Rotterdam Study, a population-based cohort study. The first subcohort started 1990 (n = 5,727), second 2000 1,769). Participants were dementia-free at baseline and followed for maximum 5 years. We calculated age-adjusted rates total, 10-year age strata, men women separately. also mortality rates, differences prevalence vascular risk factors,...
To investigate the incidence of parkinsonism and Parkinson disease (PD) in general population using in-person screening along with clinical data.In Rotterdam study, a prospective population-based cohort study people aged > or =55 years, authors assessed age- sex-specific rates PD among 6,839 participants who were free at baseline. Case finding involved baseline two follow-up visits, additional information was obtained through continuous monitoring by computer linkage to practitioners'...
<h3>Importance</h3> Cerebral microbleeds are hypothesized downstream markers of brain damage caused by vascular and amyloid pathologic mechanisms. To date, whether their presence is associated with cognitive deterioration in the general population remains unclear. <h3>Objective</h3> determine microbleeds, more specifically microbleed count location, an increased risk for impairment dementia population. <h3>Design, Setting, Participants</h3> The Rotterdam Study, a prospective population-based...