A5066554954- Acute Ischemic Stroke Management
- Intracranial Aneurysms: Treatment and Complications
- Traumatic Brain Injury and Neurovascular Disturbances
- Cerebrovascular and Carotid Artery Diseases
- Neurosurgical Procedures and Complications
- Neurology and Historical Studies
- Intracerebral and Subarachnoid Hemorrhage Research
- Antiplatelet Therapy and Cardiovascular Diseases
- Vascular Malformations Diagnosis and Treatment
- History of Medicine Studies
- Cerebrospinal fluid and hydrocephalus
- Cardiovascular Health and Disease Prevention
- Venous Thromboembolism Diagnosis and Management
- Dementia and Cognitive Impairment Research
- Cerebral Venous Sinus Thrombosis
- Neurological Disease Mechanisms and Treatments
- Atrial Fibrillation Management and Outcomes
- Stroke Rehabilitation and Recovery
- Moyamoya disease diagnosis and treatment
- History of Medical Practice
- Neurological Disorders and Treatments
- Clinical practice guidelines implementation
- Medical History and Innovations
- S100 Proteins and Annexins
- Cerebrovascular and genetic disorders
University Medical Center Utrecht
2012-2025
Utrecht University
2000-2024
Heidelberg University
1995-2017
Université Paris Cité
2017
Erasmus MC
1995-2017
Hôpital Roger Salengro
2017
Centre Hospitalier Sainte-Anne
2017
University of Nottingham
2017
University of Debrecen
2017
University of Miami
2017
Interobserver agreement for the assessment of handicap in stroke patients was investigated a group 10 senior neurologists and 24 residents from two centers. One hundred were separately interviewed by physicians different combinations. The degree recorded each observer on modified Rankin scale, which has six grades (0-5). rates corrected chance (kappa statistics). Both agreed 65 patients; they differed one grade 32 3 patients. Kappa all pairwise observations 0.56; value weighted kappa (with...
In clinical trials and observational studies there is considerable inconsistency in the use of definitions to describe delayed cerebral ischemia (DCI) after aneurysmal subarachnoid hemorrhage. A major cause for this combining radiographic evidence vasospasm with features ischemia, although multiple factors may contribute DCI. The second issue variability overlap terms used each phenomenon. This makes comparisons among difficult.An international ad hoc panel experts involved hemorrhage...
Cerebral white matter lesions are a common finding on MRI in elderly persons. We studied the prevalence of and their relation with classic cardiovascular risk factors, thrombogenic cognitive function an age- gender-stratified random sample from general population that consisted 111 subjects 65 to 84 years age. Overall, 27% had lesions. The severity increased A history stroke or myocardial infarction, factor VIIc activity, fibrinogen level were each significantly independently associated...
Cerebral white matter lesions (WMLs) have been associated with cognitive dysfunction. Whether periventricular or subcortical WMLs relate differently to function is still uncertain. In addition, it unclear whether are related specific domains such as memory psychomotor speed. We examined the relationship between and functioning in 1,077 elderly subjects randomly sampled from general population. Quantification of was assessed by means an extensive rating scale on 1.5-T magnetic resonance...
Aspirin is known to improve the outcome of patients who have had a cerebral transient ischemic attack, but optimal dose aspirin remains uncertain. Experimental evidence indicates that 30 mg daily alters platelet aggregation more favorably than 300-mg currently used in after attack or minor stroke.
Cerebral white matter lesions (WMLs) have been associated with cognitive dysfunction. Whether periventricular or subcortical WMLs relate differently to function is still uncertain. In addition, it unclear whether are related specific domains such as memory psychomotor speed. We examined the relationship between and functioning in 1,077 elderly subjects randomly sampled from general population. Quantification of was assessed by means an extensive rating scale on 1.5-T magnetic resonance...
White matter lesions are frequently found on cerebral MRI scans of elderly people and thought to be important in the pathogenesis dementia. Hyper tension has been associated with presence white but this investigated almost exclusively cross-sectional studies. We studied prospectively association these duration treatment hypertension. randomly sampled 1077 subjects aged between 60 90 years from two prospective population-based One-half study had their blood pressure measured 1975 1978 other...
Abstract The prospect of declining cognitive functions is a major fear for many elderly persons. Cerebral white matter lesions, as commonly found with magnetic resonance imaging, have been associated dysfunction in cross‐sectional studies. Only few longitudinal studies using small cohorts confirmed these findings. We examined the relation between severity lesions and decline over nearly 10‐year period 563 subjects sampled from general nondemented Dutch population. Severity was scored...
We studied 28 patients with subarachnoid hemorrhage and normal angiograms. On early CT (within 5 days) in 13 cases, blood was seen mainly or only the cisterns around midbrain. This pattern of found 1 92 a ruptured aneurysm. None unexplained perimesencephalic hemorrhages associated intracerebral hematoma intraventricular hemorrhage. The clinical features also differed from those aneurysmal hemorrhage; loss consciousness rare, after 3 months, all had returned to life. cause this benign...
According to several studies, the amount of subarachnoid blood on initial computed tomogram patients with aneurysmal hemorrhage has predictive value respect infarction and outcome. Of methods for assessing blood, none been subjected a study interobserver agreement. We describe our own method, applied in previous which amounts 10 basal cisterns fissures four ventricles are graded separately. In grading single tomograms 182 consecutive hemorrhage, agreement between pairs three observers,...
Abstract We studied retrospectively the relationship between hyponatremia and cerebral infarction in 134 consecutive patients with aneurysmal subarachnoid hemorrhage. In 44 sodium levels fell below 135 mmol/L on at least two days second tenth day after Twenty‐five of these fulfilled criteria for syndrome inappropriate secretion antidiuretic hormane. Cerebral developed 27 19 90 normal serum (p < 0.001). infarctions were more often fatal 0.01). Twenty‐six had been treated fluid restriction...
Using logistic regression, we analyzed the predictive value of a number entry variables with respect to outcome delayed cerebral ischemia, rebleeding, and poor (death or severe disability) in patients aneurysmal subarachnoid hemorrhage. The were clinical condition on admission (grades Glasgow Coma Scale, Hunt Hess system), amount intraventricular blood presence hydrocephalus computed tomogram, antifibrinolytic treatment tranexamic acid. We used data from prospectively studied population 176...
Ventricular enlargement and white matter lesions are frequent findings on cerebral magnetic resonance imaging scans of elderly subjects. In demented subjects they seem related to the severity dementia, but in nondemented their clinical significance is less clear. We investigated relation size lateral ventricles with cognitive function a population-based random sample persons. The study population consisted 90 subjects, aged 65 84 years, who were randomly selected from cohort Rotterdam Study,...