A5043334622- Reading and Literacy Development
- Chemotherapy-induced cardiotoxicity and mitigation
- Cancer Treatment and Pharmacology
- Genetics, Aging, and Longevity in Model Organisms
- Language Development and Disorders
- Early Childhood Education and Development
- Fungal and yeast genetics research
- Advanced Glycation End Products research
- Writing and Handwriting Education
- Child and Adolescent Psychosocial and Emotional Development
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cancer-related cognitive impairment studies
- Cognitive and developmental aspects of mathematical skills
- Cultural Differences and Values
- Heat shock proteins research
- Neonatal Respiratory Health Research
- Phonetics and Phonology Research
- Child and Animal Learning Development
- Intracranial Aneurysms: Treatment and Complications
- Protein Structure and Dynamics
- Spaceflight effects on biology
- Education Pedagogy and Practices
- Urban Transport and Accessibility
- Genomics, phytochemicals, and oxidative stress
- Education and Technology Integration
University of Edinburgh
2015-2024
Oxford Brookes University
1996-2022
Precise (India)
2021
Beatson West of Scotland Cancer Centre
2020
University of Glasgow
2018
Royal Hospital for Children
2017
University of California, Santa Barbara
2014
Roslin Institute
2010
University of California, Berkeley
2010
University of Geneva
2003-2006
In this article, 3 views of the relation between various forms phonological awareness (detection rhyme and alliteration detection phonemes) children's reading were tested. These are (a) that experience learning to read leads phoneme neither these is connected rhyme, (b) sensitivity phonemes, which in turn affects reading, (c) makes a direct contribution independent connection awareness. The results from longitudinal study monitored progress spelling 65 children ages 4 years 7 months 6...
Nursery rhymes are an almost universal part of young English-speaking children's lives. We have already established that there strong links between early knowledge nursery at 3;3 and their developing phonological skills over the next year a quarter. Since such known to be related success in learning read, this result suggests hypothesis acquaintance with might also affect reading. now report longitudinal data from group 64 children age 3;4 6;3 which support hypothesis. There is relation...
ABSTRACT It has been shown that there is a strong relation between children's phonological skills and the progress they make in reading. But some uncertainty whether this specific connection or it just byproduct of variations general language ability. We report evidence from longitudinal study showing sensitivity to rhyme alliteration their success reading highly cannot be accounted for terms In measures were taken group linguistic metalinguistic when 3 4 years old. The vocabulary, receptive...
There has been a growth in students with dyslexia attending university. These commonly rate writing as one of their greatest problem areas. Our research set out to describe the effects on skills compared age-matched peers and spelling-skill-matched group. Generally, texts were poorer than age controls but not spelling-skill controls. However, there no major differences "higher order" such ideas organization chronological controls, only "lower transcription spelling handwriting fluency. The...
BackgroundThe American Academy of Pediatrics recommends a permissive hypoxaemic target for an oxygen saturation 90% children with bronchiolitis, which is consistent the WHO recommendations targets in lower respiratory tract infections. No evidence exists to support this threshold. We aimed assess whether or higher management supplementation was equivalent normoxic 94% infants admitted hospital viral bronchiolitis.MethodsWe did parallel-group, randomised, controlled, equivalence trial aged 6...
BACKGROUND: Anthracycline-induced cardiotoxicity has a variable incidence, and the development of left ventricular dysfunction is preceded by elevations in cardiac troponin concentrations. Beta-adrenergic receptor blocker renin-angiotensin system inhibitor therapies have been associated with modest cardioprotective effects unselected patients receiving anthracycline chemotherapy. METHODS: In multicenter, prospective, randomized, open-label, blinded end-point trial, breast cancer non-Hodgkin...
<h2>Summary</h2><h3>Background</h3> The highest priority uncertainty for people with symptomatic cerebral cavernous malformation is whether to have medical management and surgery or alone. We conducted a pilot phase randomised controlled trial assess the feasibility of addressing this in definitive trial. <h3>Methods</h3> CARE was prospective, randomised, open-label, assessor-blinded, parallel-group at neuroscience centres UK Ireland. aimed recruit 60 any age, sex, ethnicity who had mental...
Abstract Budding yeast can be considered to have two distinct lifespans: (a) a replicative (budding, non‐chronological) lifespan , measured as the number of daughters produced by each actively dividing mother cell; and (ii) chronological ability stationary cultures maintain viability over time. In non‐dividing cells, essential components that become damaged cannot diluted out through cell division but must, necessity, turned renewed. By elevating stress resistances, many activities needed...
Background Children’s interstitial lung diseases (chILD) cover many rare entities, frequently not diagnosed or studied in detail. There is a great need for specialised advice and internationally agreed subclassification of entities collected register. Our objective was to implement an international management platform with independent multidisciplinary review cases at presentation long-term follow-up test if this would allow more accurate diagnosis. Also, quality reproducibility diagnostic...
The glyoxalase I gene ( gloA ) of Escherichia coli has been cloned and used to create a null mutant. Cells overexpressing exhibit enhanced tolerance methylglyoxal (MG) elevated rates detoxification, although the increase is not stoichiometric with change in enzyme activity. Potassium efflux via KefB also strain. Analysis physiology mutant revealed that growth viability are quite normal, unless cell challenged MG either added exogenously or synthesized by cells. strain low rate detoxification...
Performance on working memory span tasks by children with intellectual disabilities ages 11 to 12 was compared that of CA- and MA-matched controls. Limited evidence available support a "difference" position, whereby the group obtained lower scores than both CA MA groups. Some found for "developmental" performed at same level as but more poorly CA-matched group. Finally, some supported an unconventional account; in better group, although still not well Results were interpreted reference role...
Nuclear receptors (NRs) are a large family of transcription factors. One hallmark this is the ligand-binding domain (LBD), for its primary sequence, structure, and regulatory function. To date, NRs have been found exclusively in animals sponges, which has led to generally accepted notion that they arose with them. We overcome limitations sequence searches by combining profile structural predictions at genomic scale, discovered heterodimeric factors Oaf1/Pip2 budding yeast Saccharomyces...
The growth in accompanied travel to school, particularly by car, has led speculation about the cognitive and emotional impact of this change on child development. Spatial skills, knowledge environment, perceptions environment were assessed 93 children aged between 7 12 years. Children who school performed as well their unaccompanied peers spatial ability tests showed no greater concern with stranger danger. However, they a tendency cite traffic danger responses, indicated use landmarks...
Summary Prohibitin proteins have been implicated in cell proliferation, aging, respiratory chain assembly and the maintenance of mitochondrial integrity. The prohibitins Saccharomyces cerevisiae , Phb1 Phb2, strong sequence similarity with their human counterparts prohibitin BAP37, making yeast a good model organism which to study function. Both mammalian form high‐molecular‐weight complexes (Phb1/2 or prohibitin/BAP37, respectively) inner membrane. Expression declines senescence, both...
Abstract This experiment examined the relationships between working memory and two measures of achievement, namely expressive vocabulary arithmetical reasoning, in children with without intellectual disabilities (ID). For 11- to 12-year-old disabilities, tapping central executive were most important predictors both phonological making a small additional contribution vocabulary. mainstream children, was best predictor vocabulary, whereas, reasoning ability predicted by visual lesser extent...
24 preschool and school-entry children in Bombay, India, Oxford, England, were tested on their ability to distinguish between real apparent emotion response stories involving child-adult child-child interactions. Younger Indian girls did better than younger English girls, the data reveal effects due age, culture, gender, story type which suggest a more social model of understanding has been proposed by other researchers using this methodology.
The role of the KefB and KefC potassium efflux systems in protecting Escherichia coli cells against toxic effects electrophile N-ethylmaleimide has been investigated. Activation aids survival exposed to high concentrations (> 100 microM) NEM. High reduce protection afforded by activation KefC, but possession these is still important under conditions. Kdp system, which confers sensitivity methylglyoxal, did not affect Survival correlated with reduction cytoplasmic pH upon channels. In...
Survival of exposure to methylglyoxal (MG) in Gram-negative pathogens is largely dependent upon the operation glutathione-dependent glyoxalase system, consisting two enzymes, GlxI (gloA) and GlxII (gloB). In addition, activation KefGB potassium efflux system maintained closed by glutathione (GSH) activated S-lactoylGSH (SLG), intermediate formed destroyed GlxII. Escherichia coli mutants lacking are known be extremely sensitive MG. this study we demonstrate that a ΔgloB mutant as tolerant MG...
AbstractMaternal mind-mindedness has been described both as a cognitive-behavioural trait and relational construct. This study assessed stability over time consistency across relationships of maternal in relation to preschool primary school siblings compared representational interactional mind-mindedness. Mothers with two children between 2½ 10 years were twice, nine months apart (N = 32 at Time 1; N 30 2). Representational for partner/friend was also twice. Mothers' showed temporal but...