A5054713454- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Cardiovascular Function and Risk Factors
- Cardiomyopathy and Myosin Studies
- Cardiac electrophysiology and arrhythmias
- Cardiac Imaging and Diagnostics
- Cardiac pacing and defibrillation studies
- Heart Rate Variability and Autonomic Control
- Cardiovascular Disease and Adiposity
- Tissue Engineering and Regenerative Medicine
- Adipokines, Inflammation, and Metabolic Diseases
- Electrospun Nanofibers in Biomedical Applications
- Electrolyte and hormonal disorders
- Cardiovascular and exercise physiology
- Hormonal Regulation and Hypertension
- Coronary Interventions and Diagnostics
- Cardiac Fibrosis and Remodeling
- Aortic Disease and Treatment Approaches
- Venous Thromboembolism Diagnosis and Management
- Muscle metabolism and nutrition
- Neuroendocrine Tumor Research Advances
- Exercise and Physiological Responses
- Heart Failure Treatment and Management
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Mesenchymal stem cell research
Komaki City Hospital
2018-2024
Nagoya University
2005-2020
University of Tsukuba
2019
Tosei General Hospital
2011-2016
Toyo University
2015
The University of Tokyo
2007
Mie University
2005
Okazaki City Hospital
2003-2004
Background— Mineralocorticoid receptor antagonism reduces mortality associated with heart failure by mechanisms that remain unclear. The effects of the mineralocorticoid antagonist spironolactone on left ventricular (LV) function and chamber stiffness myocardial fibrosis were investigated in mildly symptomatic patients idiopathic dilated cardiomyopathy (DCM). Methods Results— Twenty-five DCM a New York Heart Association functional class I or II examined before after treatment for 12 months....
Aims The aim of the study was to identify genes that confer susceptibility coronary artery spasm and clarify interaction between genetic environmental factors in this condition.
<i>Background:</i> Bone marrow-derived mesenchymal stem cells (MSCs) can differentiate into various types of cell, and the extracellular matrix (ECM) is acknowledged to be important for regulation cell functions. In this study, we demonstrated effects ECMs on differentiation human bone MSCs a smooth muscle (SMC) lineage. <i>Methods:</i> Human (hMSCs) were cultured dishes coated with 3 ECM including laminin (LM), collagen type IV (Col-IV) fibronectin 7 days,...
Loop diuretics could adversely influence prognosis due to activation of neurohumoral mechanism in the long term. Previous study showed torasemide, a loop diuretic with anti-aldosteronergic properties, was associated lower mortality patients chronic heart failure (CHF). We evaluated effects comparison azosemide, CHF. Patients received oral therapy torasemide (8 mg/d, n = 15) or azosemide (60 for 3 months. Torasemide and were then switched, treated another treatment induced significant...
The goal of this study was to evaluate the efficacy and safety uninterrupted direct oral anticoagulant (DOAC) use warfarin administration in elderly patients undergoing catheter ablation for atrial fibrillation (AF).There is limited knowledge regarding agents AF.This retrospective included 2,164 (n = 325 ≥75 years age n 1,839 <75 age) who underwent AF. All received during procedure. We investigated occurrences periprocedural events compared these between DOAC groups younger groups.Major...
This study evaluated the compliance and stiffness of decellularized canine common carotid artery as well ureter compared it with that polytetrafluoroethylene, elastin gel combined polylactic acid tube, artery. To calculate stiffness, internal diameters cross-sectional areas were measured according to changes in intraluminal pressures using intravascular ultrasound a closed circuit system equipped syringe pump. The pressure-area curve, parameter β, diameter evaluated. Canine artery, ureter,...
Mechanism and effects of vagal response (VR) during cryoballoon ablation procedure on the cardiac autonomic nervous system (ANS) are unclear. The present study aimed to evaluate relationship between VR catheter for atrial fibrillation ANS modulation by evaluating epicardial adipose tissue (EAT) locations heart rate variability (HRV) analysis.Forty-one patients with paroxysmal (11 30 without VR) who underwent second-generation were included. EAT changes in HRV parameters compared non-VR...
This study aimed to identify the response of a salivary stress protein, extracellular heat shock protein (eHSP70), intense exercise and investigate relationship between eHSP70 immunoglobulin A (SIgA) levels in exercise. Sixteen healthy sedentary young males (means ± SD 23.8 1.5 years, 172.2 6.4 cm, 68.3 7.4 kg) performed 59 min cycling at 75% VO2max. Saliva whole blood samples were collected before (Pre), immediately after (Post), 1, 2, 3, 4 h completion (1, h). The SIgA measured by...
Data are limited regarding outcomes of cryoballoon ablation for atrial fibrillation (AF) in patients with heart failure (HF). This large-scale multicenter study aimed to evaluate the prognosis HF after AF.Among 3655 undergoing at 17 institutions, 549 (15%) (391 paroxysmal AF and 158 persistent AF) diagnosed preoperatively were analyzed. Clinical endpoints recurrence, mortality, hospitalization ablation.Most had a preserved left ventricular ejection fraction (LVEF) ≥ 50%. During mean...