A5024490058- Bone Metabolism and Diseases
- Heat shock proteins research
- Total Knee Arthroplasty Outcomes
- Bone fractures and treatments
- NF-κB Signaling Pathways
- Sirtuins and Resveratrol in Medicine
- Knee injuries and reconstruction techniques
- Sports injuries and prevention
- Metabolism, Diabetes, and Cancer
- Bone health and treatments
- Orthopedic Surgery and Rehabilitation
- Inflammatory mediators and NSAID effects
- Hip and Femur Fractures
- Calpain Protease Function and Regulation
- Spaceflight effects on biology
- Orthopaedic implants and arthroplasty
- Blood properties and coagulation
- Cytokine Signaling Pathways and Interactions
- Hip disorders and treatments
- Bone and Joint Diseases
- Autoimmune and Inflammatory Disorders Research
- Shoulder Injury and Treatment
- Bioactive natural compounds
- Foot and Ankle Surgery
- Cell Adhesion Molecules Research
Nagoya City University
2016-2025
Mizuho (Japan)
2021-2024
Gifu University
2015-2024
National Center for Geriatrics and Gerontology
2023-2024
Texas Scottish Rite Hospital for Children
2017-2023
Nagoya University
2016-2017
Background: Postoperative residual rotatory laxity remains despite improvement in surgical techniques for anterior cruciate ligament (ACL) reconstruction (ACLR). Purpose: To evaluate factors associated with pivot shift after ACLR by quantitative measurement of the before and surgery. Study Design: Case-control study; Level evidence, 3. Methods: A total 97 patients who underwent primary double-bundle between June 2016 March 2021 surgery to remove staples, at least 12 months follow-up...
To investigate the clinical and psychosocial backgrounds of frailty in rheumatoid arthritis (RA) patients.Patients with RA between 40 79 years age who visited university hospitals an urban area were recruited. Well-validated self-reported questionnaires used to evaluate patient physical function (Health Assessment Questionnaire, HAQ), depressive symptoms (Beck Depression Inventory-II, BDI-II), (Kihon Checklist). A 28-point Disease Activity Score (DAS-28) was calculated disease activity.A...
We investigated the relationship between HSP27 phosphorylation and collagen-stimulated activation of platelets in patients with diabetes mellitus (DM). Platelet-rich plasma was prepared from blood type 2 DM patients. The platelet aggregation analyzed size aggregates by an aggregometer using a laser scattering method. protein Western blotting. Phosphorylated-HSP27 PDGF-AB released were measured ELISA. phosphorylated-HSP27 levels at Ser-78 Ser-82 induced collagen directly proportional to...
An unstable trochanteric femoral fracture is a serious injury, with 1-year mortality rate of 5.4% to 24.9%, for which there currently no standard treatment method. The lag screw insertion site one the primary contact areas between cortical bone and an intramedullary nail. We hypothesized that posterolateral causes nail instability when line interferes insertion. purpose present study was investigate effect morphology on stability by simulating fractures fragment.
Neurofibromatosis type 1 (NF1, OMIM 162200), caused by NF1 gene mutations, exhibits multi-system abnormalities, including skeletal deformities in humans. Osteocytes play critical roles controlling bone modeling and remodeling. However, the role of neurofibromin, protein product gene, osteocytes is largely unknown. This study investigated neurofibromin disrupting Nf1 under Dmp1-promoter. The conditional knockout (Nf1 cKO) mice displayed serum profile a metabolic disorder with an...
Resveratrol, which is found in grape and berry skins red wine, generally known to be beneficial for human health due its anti‑inflammation antioxidant effects. We have recently reported that transforming growth factor‑β (TGF‑β) stimulates vascular endothelial factor (VEGF) synthesis through Smad‑independent pathways, such as the p38 mitogen‑activated protein (MAP) kinase, p44/p42 MAP kinase stress‑activated kinase/c‑Jun N‑terminal (SAPK/JNK) osteoblast‑like MC3T3‑E1 cells. The aim of present...
Resveratrol is well known as a natural polyphenol abundantly found in red wine. We previously reported that bone morphogenetic protein-4 (BMP-4) stimulates vascular endothelial growth factor (VEGF) synthesis via p70 S6 kinase osteoblast-like MC3T3-E1 cells. In the present study, we investigated effect of resveratrol on BMP-4-stimulated VEGF significantly suppressed release and expression levels mRNA. SRT1720, an activator SIRT1 with potencies greater than resveratrol, also reduced mRNA...
Abstract Purpose High-grade pivot shift in the anterior cruciate ligament (ACL) injured knee is a risk factor for postoperative residual shift. Procedures addition to ACL reconstruction such as anterolateral (ALL) have been performed patients with high-risk of The aim this study was investigate effect ALL primary double-bundle preoperative high-grade improve stability evaluated by quantitative measurement. Methods Patients injuries who showed grade 3 subjective and underwent combined...
It is firmly established that resveratrol, a natural food compound abundantly found in grape skins and red wine, has beneficial properties for human health. In the present study, we investigated effect of basic fibroblast growth factor (FGF-2) on osteoprotegerin (OPG) synthesis osteoblast-like MC3T3-E1 cells whether resveratrol affects OPG synthesis. FGF-2 stimulated both release expression mRNA. Resveratrol significantly suppressed FGF-2-stimulated mRNA levels OPG. SRT1720, an activator...
Resveratrol is a naturally occurring polyphenol that possesses health‑related properties, and predominantly found in grapes berries. Bone morphogenetic protein‑4 (BMP‑4) stimulates osteocalcin synthesis via p38 mitogen‑activated protein (MAP) kinase osteoblast‑like MC3T3‑E1 cells. The present study aimed to investigate the effects of resveratrol on BMP‑4‑induced osteoprotegerin (OPG) alone had no effect OPG expression levels, but significantly enhanced release. In addition, markedly...
Polyphenolic compounds in foods and beverages have beneficial effects on human health. (-)-Epigallocatechin gallate (EGCG) chlorogenic acid (CGA), a major flavonoid green tea phenolic coffee, respectively, potent properties, including antioxidative effects. Our previous study demonstrated that p70 S6 kinase acts as negative regulator tumor necrosis factor-α (TNF-α)-stimulated interleukin-6 synthesis osteoblast-like MC3T3-E1 cells. In the present study, of EGCG CGA TNF‑α‑stimulated...
AMP-activated protein kinase (AMPK) is recognized as a main regulator of energy homeostasis. Osteocalcin (OC), which produced specifically by mature osteoblasts, stored in bone matrix, strongly binds to hydroxyapatite and released into the circulation, has been marker metabolism. It recently shown that OC from osteoblasts influences metabolism hormone. We previously reported triiodothyronine (T3) stimulates synthesis osteoblast-like MC3T3-E1 cells. In present study, we investigated whether...
We previously reported that the collagen-induced phosphorylation of heat shock protein (HSP) 27 via p44/p42 mitogen-activated (MAP) kinase is sufficient to induce secretion platelet-derived growth factor (PDGF)-AB and release soluble CD40 ligand (sCD40L) from human platelets. It has been shown Rac, which belongs Rho family small GTPases, involved in platelet aggregation. In this study, we investigated role Rac collagen-stimulated PDGF-AB sCD40L Human blood was donated healthy volunteers...
Heat shock protein 27 (HSP27/HSPB1), one of the small heat proteins, is constitutively expressed in various tissues. HSP27 and its phosphorylation state participate regulation multiple physiological pathophysiological cell functions. However, exact roles osteoblasts remain unclear. In present study, we investigated role platelet-derived growth factor‑BB (PDGF‑BB)‑stimulated migration osteoblast-like MC3T3-E1 cells. PDGF-BB by itself barely upregulated expression protein, but stimulated these...